Adiponectin in Anorexia Nervosa and Bulimia Nervosa

Tagami, Tetsuya; Satoh, Noriko; Usui, Takeshi; Yamada, Kazunori; Shimatsu, Akira; Kuzuya, Hideshi

doi:10.1210/jc.2003-031260

Cited by 134 publications

(105 citation statements)

References 41 publications

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“…It is probable that the low serum leptin level in the patient reported here is primarily due to his low BMI. Such low levels of leptin have been reported in patients with anorexia nervosa, where the BMI was similar to that initially reported for our patient (34). We believe that in this patient, the pubertal delay was the result of the very low levels of serum leptin, both normal and mutant, with the increased bioactivity of the latter not being able to compensate in terms of pubertal initiation.…”

Section: Discussionsupporting

confidence: 90%

“…This is likely to be due to reduced binding of one of the assay's antibodies to the variant leptin. Low levels of serum leptin are associated with both constitutional delay of growth and puberty (31,32) and with anorexia nervosa (33,34), while serum leptin levels are positively correlated with body fat mass across a wide range of BMI in anorexic, normal weight and obese subjects (34). For patients with CDGP, although absolute levels of leptin are low, levels after adjustment for BMI are increased (35).…”

Section: Discussionmentioning

confidence: 99%

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Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene

Murray

Read²,

Banerjee³

et al. 2011

European Journal of Endocrinology

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Introduction: Leptin deficiency caused by mutations within the leptin gene (LEP) results in severe early onset obesity, hypogonadism, pubertal delay and immune system abnormalities. Constitutional delay in growth and puberty (CDGP) is a common condition seen in paediatric clinics, in which children present with delayed growth and puberty but usually also have a slim body habitus. We hypothesized that LEP variants may play a role in the phenotype seen in CDGP. Aim: To screen a group of children with CDGP for pathogenic sequence variants in LEP. Patients and methods: Denaturing HPLC was used to screen for LEP sequence variants in DNA samples from 78 children with CDGP (predominantly white males) and 112 control subjects. DNA fragments with a WAVE pattern deviant from wild type were directly sequenced. A STAT3 luciferase reporter assay in human embryonic kidney (HEK293) cells transiently transfected with the leptin receptor was used to test activity of mutant leptin. Results: One child with CDGP was identified to be heterozygous for a novel missense variant (c.68COG), which results in a proline to arginine substitution (p.P23R). This sequence variant was not identified in any of the other control subjects, but was identified in his mother who shared a similar phenotype of slim body habitus, reduced appetite and pubertal delay (menarche aged 15 years). The leptin variant showed similar stability in serum compared with wild type and did not demonstrate increased activity in an in vitro reporter gene assay. Conclusions: This is the first report of a sequence variant within the LEP gene associated with reduced body mass index rather than obesity. We hypothesize that this variant has increased bioactivity in vivo.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene

Murray

Read²,

Banerjee³

et al. 2011

European Journal of Endocrinology

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“…Although speculative, patients with lower adiposity may have increased susceptibility to NAFLD due to lower levels of adiponectin, an adipocytokine that increases fatty acid oxidation and decreases inflammation [24]. Adiponectin, although not measured in this study, has been shown to be low in NAFLD [25] and in some patients with AN [26]. The relationship between low adiponectin and NAFLD has been described in overweight patients [25], but has not been examined in AN.…”

Section: Discussionmentioning

confidence: 67%

Prevalence and Predictors of Abnormal Liver Enzymes in Young Women with Anorexia Nervosa

Fong

DiVasta²,

DiFabio³

et al. 2008

The Journal of Pediatrics

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Objective-To determine the prevalence and predictors of abnormal liver enzyme levels in ambulatory young women with anorexia nervosa (AN).Study design-In this cross-sectional study of 53 females with AN, serum concentrations of liver enzymes and hormones were measured. Anthropometric, dietary, and body composition information was collected. Correlational analyses were performed between liver enzyme concentrations and these variables.Results-Elevated alanine aminotransferase (ALT) and gamma-glutamyltranspeptidase (GGT) levels were found in 14 subjects (26%) and 5 subjects (9%), respectively. ALT and GGT were inversely correlated with body mass index (r = −0.27 to −0.30, p ≤ 0.049) and percentage body fat (r = −0.36 to −0.47, p ≤ 0.007), but showed no relationship with lean body mass. Subjects with percentage body fat < 18% had higher ALT levels than those above this threshold (median 26.5 vs. 18.0 U/L, p = 0.01). Liver enzyme concentrations did not correlate with dietary variables, except for GGT and percentage of calories from protein (r = 0.28, p = 0.04).Conclusions-Serum ALT and GGT concentrations are inversely related to adiposity in young women with AN. Future studies are needed to determine if these liver enzyme elevation signify unrecognized, clinically relevant liver disease.Keywords eating disorders; adolescents; liver; malnutrition; alanine aminotransferase; gammaglutamyltranspeptidase Corresponding author: Catherine M. Gordon, MD, MSc, Divisions of Adolescent Medicine and Endocrinology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02215, Tel: 617-355-8492, Fax: 617-730-0195, Email: catherine.gordon@childrens.harvard.edu For reprints, please contact the corresponding author, Catherine M. Gordon, MD, MSc. Edited by WFB Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In this study, we sought to determine the prevalence and predictors of abnormal liver enzyme levels in ambulatory young women with AN. We hypothesized that individuals with more severe disease, as reflected by lower body mass index (BMI) and body fat, would be more likely to exhibit elevated ALT and gamma-glutamyltranspeptidase (GGT) levels. We also hypothesized that insulin resistance would be a predictor of abnormal ALT and GGT concentrations. We predicted that there would be a significant association between macronutrient caloric distribution and liver enzyme concentrations. Methods DesignThis study was a cross-sectional evaluation of data obtained from the baseline visit of a clinical bone density trial. SubjectsAdolescents and young women with AN were recruited from the Chil...

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“…Serum adiponectin has been found to be either increased Pannacciulli et al, 2003), normal (Iwahashi et al, 2003) or decreased (Tagami et al, 2004) in AN patients. Likewise, serum plasma resistin levels have been found to be either decreased (Dostalova et al, 2006) or normal (Dolezalova et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

et al. 2010

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Objective: The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN). Subjects/Methods: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-a and interleukin (IL)-1b), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form. Results: BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (Po0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (Po0.05 for both). Conclusions: Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.

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Adiponectin in Anorexia Nervosa and Bulimia Nervosa

Cited by 134 publications

References 41 publications

Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene

Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene

Prevalence and Predictors of Abnormal Liver Enzymes in Young Women with Anorexia Nervosa

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

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