Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease

Ohashi, Koji; Ouchi, Noriyuki; Kihara, Shinji; Funahashi, Tohru; Nakamura, Tadashi; Sumitsuji, Satoru; Kawamoto, Toshiharu; Matsumoto, Satoru; Nagaretani, Hiroyuki; Kumada, Masahiro; Okamoto, Yoshihisa; Nishizawa, Hitoshi; Kishida, Ken; Maeda, Norikazu; Hiraoka, Hisatoyo; Iwashima, Yoshio; Ishikawa, Kazuhiko; Ohishi, Mitsuru; Katsuya, Tomohiro; Rakugi, Hiromi; Ogihara, Toshio; Matsuzawa, Yūji

doi:10.1016/j.jacc.2003.10.049

Cited by 177 publications

(107 citation statements)

References 35 publications

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“…However, it has been shown to influence the allelespecific differential expression of the adiponectin gene in human omental adipose tissue [20]. Previous studies have reported increased [8], decreased [21] or unchanged [18] levels of adiponectin in subjects with the T45G variant. In our study, a lower adiponectin level was found in the G carriers, but the result was only significant in the male subjects.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study

et al. 2006

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Aims/hypothesis Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not in Pima Indians. The aim of this study was to determine the contribution made by ADIPOQ gene variants to glycaemic status in southern Chinese individuals. Subjects and methods Sixty unrelated subjects were screened for single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene by direct sequencing. The association of tagging SNPs with the outcome of glycaemic status in 262 subjects with impaired glucose tolerance (IGT) was examined in a 5-year prospective study. Results We identified 15 polymorphisms in the ADIPOQ gene, ten of them constituting the tagging SNPs. At 5 years, 39.7% of the subjects with IGT had regressed to NGT, 41.2% had persistent IGT or impaired fasting glucose and 19.1% had developed diabetes. Only the T45G polymorphism was associated with persistent hyperglycaemia at 5 years (p=0.001). Haplotypes formed by the addition of other SNPs, as haplotype blocks or pairs, did not confer greater association than T45G alone. On logistic regression analysis, T45G independently predicted persistent hyperglycaemia at 5 years (OR=2.25, 95% CI 1.29-3.95, G carriers vs TT; p=0.005). It also predicted persistent hyperglycaemia in a nested case-control study involving 158 sex-and age-matched controls with persistent NGT (p=0.012, adjusted for BMI), and that of diabetes or glycaemia progression (p<0.05) in a meta-analysis that also included two published studies in Europid subjects. Conclusions/interpretation Our findings support a significant role of this common ADIPOQ gene polymorphism in predicting glycaemic status in southern Chinese people.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study

et al. 2006

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“…Males [4] 139.578.2 Females [26] 115.2711.1 Fat % [31] 60.079.1 HOMA index [23] 4.074.2 Fasting glucose (mmol/l) [32] 4.970.6 Fasting insulin (mU/l) [24] 19.5716.8 Leptin (mg/l)…”

Section: Discussionmentioning

confidence: 99%

“…22 Adiponectin serum levels have a heritability of about 30%, 18 indicating that genetic variation within or outside the adiponectin gene could affect the expression of the gene. Several studies have reported an effect on serum adiponectin levels for different single nucleotide polymorphisms (SNPs) in the APM1 gene, 10,12,[17][18][19]23 but to our knowledge only one study has focused on the effect of a genetic marker on the APM1 mRNA expression in omental adipose tissue, reporting increased mRNA levels for the APM1 T94G G-allele. 24 Visceral adipose tissue is more metabolically active than subcutanoeus adipose tissue and is of greater importance for the development of obesity-related complications.…”

Section: Introductionmentioning

confidence: 99%

A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

et al. 2005

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Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.574.9 kg/m 2 ) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r ¼ 0.54, P ¼ 0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele

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“…However, SNP+45 GG genotype had no effect on phenotype, that is, on serum adiponectin protein concentrations [35]. Ohashi et al [36] also genotyped gDNA isolated from whole blood specimens procured from 383 coronary artery disease (CAD) individuals and 368 controls ( Table 2, row H). MetS was diagnosed if total cholesterol >5.6 mmol/l, triglycerides >1.69 mmol/l, HDL-cholesterol <1.03 mmol/l, and blood pressure of systolic !140 mm Hg and diastolic !90 mm Hg were present.…”

Section: Forty-two [ 2 5 _ T D $ D I F F ] Snps[ 7 _ T D $ D I F F ]mentioning

confidence: 99%

Blood-Based Biomarkers for Metabolic Syndrome

O’Neill

Bohl

Gregersen

et al. 2016

Trends in Endocrinology & Metabolism

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Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease

Abstract: The I164T mutation in the adiponectin gene was a common genetic background associated with the metabolic syndrome and CAD in the Japanese population.

Cited by 177 publications

References 35 publications

Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study

Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study

A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

Blood-Based Biomarkers for Metabolic Syndrome

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