Adiponectin homolog osmotin, a potential anti-obesity compound, suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes

Jo, Min Gi; Kim, Min Woo; Jo, Myeung Hoon; Abid, Noman Bin; Kim, Myeong Ok

doi:10.1038/s41366-019-0383-3

Cited by 18 publications

(18 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional analyses revealed similar biological effects, evaluated as the induction of IL-6 production in synovial fibroblasts, of fAd (5 ug/ml) and osmotin peptide (5 ug/ml) (181,182). Studies with in-vivo, in-vitro treatment of osmotin also revealed its adiponectin's memetic effect toward obesity, diabetes and related fatty liver, cardiovascular diseases (183)(184)(185)(186). The activation of AdipoRs mediated downstream signaling pathways including AdipoRs/PPARα (185) and AdipoR1/PI3K/AKT (183) upon osmotin treatment, further confirmed the agonist activity of osmotin peptide to AdipoRs, in particularly to AdipoR1 (187).…”

Section: Osmotinmentioning

confidence: 80%

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

Liu¹,

Sweeney

2019

Front. Endocrinol.

View full text Add to dashboard Cite

Cardiometabolic diseases encompass those affecting the heart and vasculature as well as other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver disease. These diseases tend to have common risk factors, one of which is impaired adiponectin action. This may be due to reduced bioavailability of the hormone or resistance to its effects on target tissues. A strong negative correlation between adiponectin levels and cardiometabolic diseases has been well-documented and research shown that adiponectin has cardioprotective, insulin sensitizing and direct beneficial metabolic effects. Thus, therapeutic approaches to enhance adiponectin action are widely considered to be desirable. The complexity of adiponectin structure and function has so far made progress in this area less than ideal. In this article we will review the effects and mechanism of action of adiponectin on cardiometabolic tissues, identify scenarios where enhancing adiponectin action would be of clinical value and finally discuss approaches via which this can be achieved.

show abstract

Section: Osmotinmentioning

confidence: 80%

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

Liu¹,

Sweeney

2019

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Osmotin has been shown to exert the multiple effects in different cell types including ECs, monocytes/ macrophages, VSMCs, adipocytes, and cardiomyocytes [10,11,33] . The anti-atherosclerotic effects of osmotin have been investigated using cultured human vascular cells in vitro.…”

Section: In Vitro Anti-atherosclerotic Effects Of Osmotinmentioning

confidence: 99%

“…Cross-talk between perivascular adipocytes and vascular cells in blood vessel wall modulates the formation of atherosclerosis by releasing adipocytokines [47] . Similar to adiponectin [48] , osmotin suppresses the differentiation and proliferation of adipocytes by regulating the expression of p21, p27, and cyclin-dependent kinase 2, as well as improves glucose uptake in 3T3-L1 adipocytes [33] .…”

Section: Suppressive Effects Of Osmotin On the Glucose Uptake And Difmentioning

confidence: 99%

“…Recently, the anti-atherosclerotic effects of osmotin have also been investigated using a variety of animal models in vivo. Treatment with osmotin suppresses abdominal fat accumulation in C57BL/6 mice fed with a high-fat diet [33] . In Apoe -/mice on a high-cholesterol diet, chronic infusion of osmotin prevents the development of aortic atherosclerotic lesions accompanied by an improved vascular inflammation and plaque instability [10] .…”

Section: In Vivo Anti-atherosclerotic Effects Of Osmotinmentioning

confidence: 99%

“…Several lines of evidence have recently shown the protective effects of osmotin against atherosclerosis, hyperlipidemia, diabetes, and obesity [10,[31][32][33] . This review article summarizes the therapeutic properties of osmotin for preventing atherosclerosis and myocardial ischemia-reperfusion injury as well as inflammation and neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic properties of the new phytochemical osmotin for preventing atherosclerosis

Watanabe¹

2020

View full text Add to dashboard Cite

show abstract

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.

show abstract

Adiponectin homolog osmotin, a potential anti-obesity compound, suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes

Cited by 18 publications

References 65 publications

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

Therapeutic properties of the new phytochemical osmotin for preventing atherosclerosis

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Contact Info

Product

Resources

About