Adiponectin Concentration in Umbilical Cord Serum Is Positively Associated with the Weight Ratio of Fetus to Placenta

Kadowaki, Koji; Waguri, Masako; Nakanishi, Isao; Miyashita, Yoshihiro; Nakayama, Masahiro; Suehara, Noriyuki; Funahashi, Tohru; Shimomura, Iichiro; Fujita, Tomio

doi:10.1210/jc.2005-2846

Cited by 30 publications

(28 citation statements)

References 39 publications

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“…Adiponectin has recently been reported as an associate of FPI independent of fetal adiposity (2), which we speculated might reflect an augmentation of insulin sensitivity by adiponectin and consequent increased fetal growth (2). By contrast, though we confirmed the relationships of adiponectin and FPI, we did not show a correlation of adiponectin to birth weight, which suggests that other mechanisms are responsible.…”

Section: Research Design Andcontrasting

confidence: 92%

“…Fetal adiponectin, an adipokine with insulin-sensitizing and antiinflammatory effects, has been identified as the first biomarker associated with FPI (2). In this study, we examined FPI and its relation to hormonal indexes, in particular those of insulin and adiponectin, in offspring of mothers with type 1 diabetes (OT1D), a group observed to exhibit reduced FPI (3) and adiponectin (4) and to be subject to in utero programming of glucose intolerance (5).…”

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confidence: 99%

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Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

et al. 2008

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OBJECTIVE -To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.RESEARCH DESIGN AND METHODS -We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.RESULTS -Placental weight (P ϭ 0.009) and gestation-adjusted birth weight (P Ͻ 0.001) were increased in OT1D, but FPI was unaltered (P ϭ 0.33). Placental weight correlated with birth weight (P Ͻ 0.001) and cord leptin (P Ͻ 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.CONCLUSIONS -Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study. Diabetes Care 31:1123-1125, 2008P lacental weight is strongly associated with birth weight, with experimental and epidemiological studies demonstrating associations of reduced fetal weight-to-placental weight ratio index (FPI) with later hypertension, glucose intolerance, and coronary heart disease, suggesting in utero programming of adult disease (1). Fetal adiponectin, an adipokine with insulin-sensitizing and antiinflammatory effects, has been identified as the first biomarker associated with FPI (2). In this study, we examined FPI and its relation to hormonal indexes, in particular those of insulin and adiponectin, in offspring of mothers with type 1 diabetes (OT1D), a group observed to exhibit reduced FPI (3) and adiponectin (4) and to be subject to in utero programming of glucose intolerance (5). RESEARCH DESIGN ANDMETHODS -A comprehensive description of prospective recruitment and exclusion criteria are available in previous publications (4,6). A total of 122 OT1D and 46 control subjects were available for analysis. FPI (birth weight [grams] divided by placental weight [grams]) was calculated for each delivery. Maternal A1C and cord plasma insulin, leptin, IGF-1, IGFBP-3, adiponectin, C-reactive protein (CRP), and intracellular adhesion molecule-1 were assayed centrally (4,6). Hemoglobin and hematocrit (available in 32 control subjects and 81 OT1D) were measured locally by routine clinical hematological analyzers. A1C was included when assessed between weeks 26 and 34 of pregnancy (available in 90 OT1D).Results are presented as mean Ϯ SD or unadjusted median (interquartile range). Pearson correlations, general linear models, and stepwise logistic regression (P Յ 0.15 for inclusion of predictors) on log-transformed variables were used to assess relationships.RESULTS -Mean Ϯ SD birth weight (control subjects 3,553 Ϯ 520 g, OT1D 3,778 Ϯ 701 g; P Ͻ 0.001) and placental weight (control subjects 627 g [551-700], OT1D 700 g [600 -800]; P Ͻ 0.001) were increased in OT1D, with no ...

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Section: Research Design Andcontrasting

confidence: 92%

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confidence: 99%

Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

et al. 2008

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“…Recent publications have tried to clarify the relationship between maternal and newborn serum levels of ApN, but failed to find a statistically significant correlation (p = not significant, r = –0.3) [38] which could mean that the ApN was only produced by the fetal-placental unit as a compensatory mechanism in order to ensure normal ApN production and subsequent normal fetal development. This hypothesis is supported by recent evidence of Kadowaki et al [39] which shows that these adipokines play a role in tissue differentiation and fetal growth, with lower cord-blood levels of ApN in newborns disproportionately smaller than their placental size [38,39]. …”

Section: Discussionsupporting

confidence: 54%

First-Trimester Adiponectin and Subsequent Development of Preeclampsia or Fetal Growth Restriction

Valdés

Lattes

Muñoz

et al. 2011

Gynecol Obstet Invest

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Background/Aims: The evidence regarding the utility of assessing first-trimester adiponectin (ApN) serum levels in early prediction of preeclampsia (PE) and fetal growth restriction (FGR) is contradictory. This study aims to determine the role of maternal serum ApN levels as an early predictor of PE and FGR. Methods: A prospective case-control study among a pregnant population who attended their 11- to 14-week ultrasound scan at the University of Chile’s Clinical Hospital’s Fetal Medicine Unit. We included patients who developed PE or FGR (10 cases per group) and 35 healthy controls. We determined ApN levels in blood samples from these 55 patients using a commercial ELISA kit and assessed the relationship of ApN levels with variables like development of PE, FGR, weight at birth and maternal BMI. Results: There were no significant differences among first-trimester ApN serum levels in the groups. Average concentrations were 8, 6.8 and 10.8 ng/ml for the control, PE and FGR groups, respectively. Conclusion: In our study, maternal serum ApN levels were not useful in predicting subsequent development of PE and FGR. However, maternal serum ApN concentration adjusted by BMI was significantly higher during the first trimester in women who later developed FGR.

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“…16,37 By contrast, in pregnancies without GDM a positive correlation between fetal adiponectin and fetus-toplacenta weight ratio has been shown, suggesting a possible role of adiponectin in fetal growth. 12 Cseh et al have found an inverse relationship between the newborn's body length, head circumference and body weight and maternal TNF-alpha, leptin and C-peptide levels in pregnancies with GDM. 42 In our study, no correlation was found between maternal IL-1β and birth weight.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 It has also been proposed that adiponectin may play a role in regulating fetal growth in pre-term and term infants of non-diabetic pregnancies. 12,13 Previous studies have shown hypoadiponectinemia in the 2 nd trimester of pregnancies complicated by GDM, as compared to normal pregnancies. 14,15 In addition, adiponectin is negatively correlated to 2h plasma glucose and insulin concentrations of the oral glucose tolerance test in pregnancies with and without GDM 16 and positively to insulin secretion sensitivity index only in pregnancies with GDM.…”

Section: I) Anthropometric Measurementsmentioning

confidence: 97%

Pre- and early post-partum adiponectin and Interleukin-1beta levels in women with and without gestational diabetes

Vitoratos¹,

Valsamakis²,

Mastorakos³

et al. 2008

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OBJECTIVE: To investigate maternal serum adiponectin and Ιnterleukin-1beta (IL-1β) levels during the pre-and post-partum periods in pregnant women with and without Gestational Diabetes Mellitus (GDM). DESIGN: Thirty control pregnant Caucasian women without GDM and thirty Body Mass Index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between the 24 th and 26 th week of their pregnancy and on the 3 rd day postpartum underwent anthropometry and had serum blood taken. Both groups, were monitored by a dietitian and had comparable weight gain during pregnancy. Birth weight was also measured. RESULTS: At the 3 rd day postpartum, compared to the 2 nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, lower serum IL-1β levels and lower Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) values. At the 2 nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, higher IL-1β and higher HOMA-IR values compared to women without GDM. At the 3 rd day postpartum, women with GDM had lower serum adiponectin levels, higher IL-1β and higher HOMA-IR values compared to women without GDM. Second trimester serum adiponectin values of women with GDM correlated negatively with birth weight. CONCLUSIONS: Gestational diabetes is a state of insulin resistance associated with altered levels of proinflammatory cytokines, increased IL-1β and decreased adiponectin values. Both of these alterations might be attributed to placental pathology in pregnancies with GDM.

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Adiponectin Concentration in Umbilical Cord Serum Is Positively Associated with the Weight Ratio of Fetus to Placenta

Abstract: In cord hyperadiponectinemia, fetuses tend to be disproportionately larger for their placental weight and vice versa in cord hypoadiponectinemia. APN is shown to be the first biomarker positively associated with F/P weight ratio.

Cited by 30 publications

References 39 publications

Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

First-Trimester Adiponectin and Subsequent Development of Preeclampsia or Fetal Growth Restriction

Pre- and early post-partum adiponectin and Interleukin-1beta levels in women with and without gestational diabetes

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