Adiponectin binds C1q and activates the classical pathway of complement

Peake, Philip W.; Shen, Y.G.; Walther, Alexandra; Charlesworth, J. A.

doi:10.1016/j.bbrc.2007.12.161

Cited by 63 publications

(48 citation statements)

References 27 publications

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“…The authors hypotesize the binding of C1q leads to conformational changes in the adiponectin molecule, which induces the classical pathway of complement activation. Adiponectin may play an important role in immunity by its direct biological effect [7]. There is also evidence of adiponection accumulation on injured vascular arterial wall (but not in healthy one).…”

Section: Adiponectin and Atherosclerosismentioning

confidence: 99%

“…In the heart tissue adiponectin thus acts as a regulator of cardiac damage through its antiinflammatory effect and as a factor preventing the reconstruction of cardiac tissue. In order to become a useful biomarker of cardiovascular risk, it is necessary to determine which of its isoforms exhibit cardioprotectivity, and to clarify mechanism of their action in various pathophysiological conditions [7].…”

Section: Adiponectin and Atherosclerosismentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Novotny¹,

Vaverková²,

Karásek³

2012

Lipoproteins - Role in Health and Diseases

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Section: Adiponectin and Atherosclerosismentioning

confidence: 99%

Section: Adiponectin and Atherosclerosismentioning

confidence: 99%

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Novotny¹,

Vaverková²,

Karásek³

2012

Lipoproteins - Role in Health and Diseases

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“…Adipokines and immune factors interact locally, as e.g. adiponectin and pentraxin, both of which bind C1q (Peake et al, 2008 andBottazzi et al, 1997), thus interweaving different systems and effecting activation.…”

Section: Role Of Complement In Homoiostasis and Immune Defense Of Adimentioning

confidence: 99%

Dual role of complement in adipose tissue

Pattrick

Luckett

Yue

et al. 2009

Molecular Immunology

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Once thought of as purely the body's chief energy store, adipose tissue and its constituent adipocytes have emerged as both a metabolic entity and an endocrine one.Complement is generally thought of as originating mainly from hepatic synthesis but also from synthesis by the macrophage phagocyte system. This review revisits early descriptions of adipocytic synthesis of complement components and highlights the need of a systematic analysis of the contribution of adipose tissue to systemic inflammation in order to appreciate the immunological activity of this tissue. AbstractOnce thought of as purely the body's chief energy store, adipose tissue and its constituent adipocytes have emerged as both a metabolic entity and an endocrine one.Complement is generally thought of as originating mainly from hepatic synthesis but also from synthesis by the macrophage phagocyte system. This review revisits early descriptions of adipocytic synthesis of complement components and highlights the need of a systematic analysis of the contribution of adipose tissue to systemic inflammation in order to appreciate the immunological activity of this tissue.

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“…Since the CP is known as the major pathway of the HCA and is supported by lectin and AP, many additional factors, which contribute to complement activation of the CP, have been recognised. For example, the structure of the bacterial membrane, especially protein contents of lipopolysaccharide (LPS)-like lipid A (Morrison and Kline 1977), O-antigen (Merino et al 1998;Eisenschenk et al 1999), porin (Loos and Clas 1987;Alberti et al 1996), kind of vaccine (Bredt et al 1977), age (Yonemasu et al 1978;Tyler et al 1988;Durandy 2003), C-reactive protein (Jiang et al 1991;Mold et al 1999), adiponectin protein (Peake et al 2008), and sex (Olaho-Mukani et al 1995), acute phase response (Wimmers et al 2003) are strong evidences for this.…”

Section: Associationmentioning

confidence: 99%

Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review

Khoa¹

2013

Vet. Med. - Czech

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ABSTRACT:The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6-9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health.

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Adiponectin binds C1q and activates the classical pathway of complement

Cited by 63 publications

References 27 publications

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Adiponectin: A Perspective Adipose Tissue Marker with Antiinflammatory and Antiaterogenic Potencial

Dual role of complement in adipose tissue

Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review

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