Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines

Nigro, Ersilia; Orlandella, Francesca Maria; Polito, Rita; Mariniello, Raffaela Mariarosaria; Monaco, Maria Ludovica; Mallardo, Marta; Stefano, Anna Elisa De; Iervolino, Pasquale; Salvatore, Giuliana; Daniele, Aurora

doi:10.1007/s13105-021-00789-x

Cited by 19 publications

(12 citation statements)

References 36 publications

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“…They demonstrated that leptin slightly increased the aggressive phenotype of PTC cells by stimulating proliferation and migration of both TPC and K1 cells [74]. Similar results were obtained by Nigro et al [75] in both BCPAP and K1 cell lines.…”

Section: Leptinsupporting

confidence: 76%

Obesity and Thyroid Cancer Risk: An Update

Franchini

Palatucci

Colao

et al. 2022

IJERPH

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Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence has increased dramatically in recent years. In parallel, the prevalence of overweight and obesity has also increased, suggesting a possible link between these two diseases. Indeed, low-grade chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in obese patients are all factors that contribute to the occurrence and growth of TC. In this review, the most recent evidence supporting the potential role of the mechanisms linking obesity to TC will be discussed.

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Section: Leptinsupporting

confidence: 76%

Obesity and Thyroid Cancer Risk: An Update

Franchini

Palatucci

Colao

et al. 2022

IJERPH

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“… 218 , 219 Secondly, inflammatory adipokines secreted by WAT, such as IL-6, leptin, and adiponectin, can influence STAT3, AKT, JNK, and MEK/ERK signal pathways in cancer cells directly, consequently upregulating the expression of proliferation and invasion-related genes. 220 – 222 Finally, adipocytes are also involved in building a beneficial microenvironment for cancer cells. For example, adipocytes can decrease the natural killer cell toxicity, activate the inflammatory phenotype of macrophages, and promote fibrosis and vascularization in tumors.…”

Section: The Developmental Origin and Anatomical Location Of Thermoge...mentioning

confidence: 99%

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Yin

Chen

Ruze

et al. 2022

Sig Transduct Target Ther

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The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has reached pandemic levels worldwide and increased gradually. Most of them are listed on the table of high-risk factors for malignancy, and metabolic disorders systematically or locally contribute to cancer progression and poor prognosis of patients. Importantly, adipose tissue is fundamental to the occurrence and development of these metabolic disorders. White adipose tissue stores excessive energy, while thermogenic fat including brown and beige adipose tissue dissipates energy to generate heat. In addition to thermogenesis, beige and brown adipocytes also function as dynamic secretory cells and a metabolic sink of nutrients, like glucose, fatty acids, and amino acids. Accordingly, strategies that activate and expand thermogenic adipose tissue offer therapeutic promise to combat overweight, diabetes, and other metabolic disorders through increasing energy expenditure and enhancing glucose tolerance. With a better understanding of its origins and biological functions and the advances in imaging techniques detecting thermogenesis, the roles of thermogenic adipose tissue in tumors have been revealed gradually. On the one hand, enhanced browning of subcutaneous fatty tissue results in weight loss and cancer-associated cachexia. On the other hand, locally activated thermogenic adipocytes in the tumor microenvironment accelerate cancer progression by offering fuel sources and is likely to develop resistance to chemotherapy. Here, we enumerate current knowledge about the significant advances made in the origin and physiological functions of thermogenic fat. In addition, we discuss the multiple roles of thermogenic adipocytes in different tumors. Ultimately, we summarize imaging technologies for identifying thermogenic adipose tissue and pharmacologic agents via modulating thermogenesis in preclinical experiments and clinical trials.

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“…This was demonstrated in leptin expression where it decreased in D7 cells but was not significantly reduced in D5 cultures. The effect of adiponectin on leptin expression is remarkably limited, and instead, adiponectin appears to influence leptin-mediated affects by antagonizing leptin activity [54,55], in part by abrogating the signal transduction capacity of its receptor [56][57][58]. Nevertheless, Jarde et al [59] reported a tendency towards a reduction in leptin expression in adiponectin-treated MCF-7 breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum

Flores

Ramirez

Ayala

et al. 2022

Veterinary Sciences

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Luteal angiogenesis is regulated by pro-angiogenic hormones including fibroblast growth factor 2 (FGF2) and angiopoietin 1 (Ang1), which are regulated by the adipokine leptin during development. Another adipokine, adiponectin, exhibits an inverse relationship with leptin and has been identified in the CL. Therefore, it is hypothesized that adiponectin will influence pro-angiogenic hormones in the developing porcine CL. Crossbred sows were randomly allocated to one of two days of the estrous cycle, day 5 (D5; n = 4) or day 7 (D7; n = 5) for CL collection. Tissue was processed for immunohistochemical localization of adiponectin receptor 2 (AdipoR2), gene expression of FGF2, Ang1, leptin, AdipoR2, and cell culture for adiponectin treatment. The expression of AdipoR2 tended (p = 0.09) to be higher in D7 lutea and was more prevalently localized to the cell surface of large and small luteal cells than in D5 tissue. Adiponectin influenced (p ≤ 0.05) FGF2, leptin, and AdipoR2 gene expression relative to the dose and day (D5 or D7). Collectively, the evidence supports the supposition that adiponectin influences angiogenic factors in the developing CL.

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Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines

Cited by 19 publications

References 36 publications

Obesity and Thyroid Cancer Risk: An Update

Obesity and Thyroid Cancer Risk: An Update

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum

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