Adiponectin and Carotid Intima-Media Thickness in the Northern Manhattan Study

Abstract

Background and purpose Adiponectin is an insulin-sensitizing plasma protein expressed in adipose tissue and suggested to play a role in atherosclerosis and cardiovascular disease. Data are lacking on the relationship between adiponectin and carotid intima-media thickness (IMT) in ethnically heterogeneous populations. We examined the relationship between adiponectin and IMT, a marker of atherosclerosis, in a multi-ethnic cohort study of stroke risk factors. Methods Participants were from the Northern Manhattan Study (N=1522, mean age 66±9 years, 60% female, 20% black, 18% white, 60% Hispanic). Adiponectin was measured from baseline plasma samples and IMT was assessed by high-resolution B-mode carotid ultrasound. Regression models were used to examine the association between adiponectin, assessed continuously and in quartiles, and IMT, controlling for demographics and vascular risk factors. Results The mean adiponectin level was 10.3±5.2 μg/ml (median=9.2, range=2.3-53.3), and the mean IMT was 0.91±0.08 mm. Adiponectin was inversely associated with IMT, even after controlling for demographics and vascular risk factors. Individuals in the first quartile of adiponectin had mean IMT that was on average 0.02 mm greater than those in the top quartile. The relationship between adiponectin and IMT appeared to be stronger among those with diabetes. Conclusion Our findings suggest that low adiponectin is associated with increased IMT in a multi-ethnic cohort and support a protective role for adiponectin in atherosclerosis.

Czy adiponektyna stanowi czynnik ryzyka występowania napadów przemijającego niedokrwienia mógu/przemijającego niedokrwienia mózgu?

“…In postmenopausal women, Ogorodnikova et al found no evidence of an association between high molecular weight adiponectin levels and ischaemic stroke [19]. Secondly, several medications may affect ADP levels [30,31], but we could not pay attention to drug use. Another limitation of the study was the small sample size.…”

Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

“…[4][5][6] Adiponectin levels were reduced in intracranial atherosclerosis versus other stroke etiologies 51 and correlated inversely with carotid intima media thickness. 52,53 Stroke continues to have a disproportionate impact on mortality for blacks compared to whites. 54,55 Incidence data from NOMAS have demonstrated race-ethnic differences in stroke incidence: Blacks had a 2.4-fold increased annual stroke incidence, and Hispanics a 2-fold increased annual stroke incidence compared to whites.…”

Evaluation of the Effects of Adipocytokines on Prognosis in Ischemic Cerebrovascular Events

“…In vivo studies performed in human aortic endothelial cells showed that adiponectin caused a dose-dependent decrease in adhesion molecules that regulate vascular inflammatory response, and lower adiponectin levels were associated with larger carotid artery intima-media thickness (12,13). However, a crosssectional study in patients with and without a previous history of ischemic cerebrovascular disease found an association between low adiponectin levels and ischemic cerebrovascular events (14).…”