Adiponectin and adiponectin receptors in common carp (Cyprinus carpio): Tissue distribution and their expressions in response to high-carbohydrate and high-lipid diets

Pi, Daming; Wang, Junli; Zhao, Mengjuan; Li, Mingyu; Zhang, Yingxin; Qin, Chaobin; Yang, Liping; Yan, Xiao; Nie, Guoxing

doi:10.1016/j.aqrep.2022.101341

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…The first identification of adiponectin in fish was reported in zebrafish ( 44 ). Since then, this adipokine has been identified in other fish species, such as rainbow trout ( Oncorhynchus mykiss ), ayu ( Plecoglossus altivelis ), large yellow croaker ( Larimichthys crocea ) and common carp ( Cyprinus carpio ) ( 8 , 45 – 47 ). The main regions of mammalian adiponectin have been analyzed in fish, and the globular domain, which is involved in receptor binding, is the most conserved one.…”

Section: Adipokinesmentioning

confidence: 99%

“…The highest expression level of adiponectin in ayu is found in the adipose tissue, as reported in mammals ( 49 ). In zebrafish, rainbow trout, large yellow croaker, common carp, and grass carp, the expression in the muscle is higher than that in the adipose tissue ( 5 , 8 , 44 , 45 , 47 , 48 ), but still remains to be evaluated whether this peptide could be also considered a myokine in these species. adiponectin is also expressed in other tissues, such as brain, liver, kidney or heart with variable levels depending on the species ( 8 ).…”

Section: Adipokinesmentioning

confidence: 99%

“…Regarding adiponectin receptors, and similarly to mammals, some fish species have two forms (AdipoR1 and AdipoR2), while zebrafish, grass carp and common carp have two isoforms of AdipoR1 besides AdipoR2 ( 44 , 47 , 48 ). The homologies with mammalian sequences are between 70 and 80%.…”

Section: Adipokinesmentioning

confidence: 99%

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Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

et al. 2023

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Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokines and osteokines respectively, have been identified in mammals playing key roles in organ/tissue development and function. Some of them are released into the circulation acting as classical hormones, but they can also act locally showing autocrine/paracrine effects. In recent years, some of these cytokines have been identified in fish models of biomedical or agronomic interest. In this review, we will present their state of the art focusing on local actions and inter-tissue effects. Adipokines reported in fish adipocytes include adiponectin and leptin among others. We will focus on their structure characteristics, gene expression, receptors, and effects, in the adipose tissue itself, mainly regulating cell differentiation and metabolism, but in muscle and bone as target tissues too. Moreover, lipid metabolites, named lipokines, can also act as signaling molecules regulating metabolic homeostasis. Regarding myokines, the best documented in fish are myostatin and the insulin-like growth factors. This review summarizes their characteristics at a molecular level, and describes both, autocrine effects and interactions with adipose tissue and bone. Nonetheless, our understanding of the functions and mechanisms of action of many of these cytokines is still largely incomplete in fish, especially concerning osteokines (i.e., osteocalcin), whose potential cross talking roles remain to be elucidated. Furthermore, by using selective breeding or genetic tools, the formation of a specific tissue can be altered, highlighting the consequences on other tissues, and allowing the identification of communication signals. The specific effects of identified cytokines validated through in vitro models or in vivo trials will be described. Moreover, future scientific fronts (i.e., exosomes) and tools (i.e., co-cultures, organoids) for a better understanding of inter-organ crosstalk in fish will also be presented. As a final consideration, further identification of molecules involved in inter-tissue communication will open new avenues of knowledge in the control of fish homeostasis, as well as possible strategies to be applied in aquaculture or biomedicine.

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Section: Adipokinesmentioning

confidence: 99%

Section: Adipokinesmentioning

confidence: 99%

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Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

et al. 2023

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“…Adipor2 is an important hormone secreted by adipocytes to regulate glucose and lipid metabolism [53]. In combination with adiponectin, it activates a signaling cascade that increases PPARα activity and accelerates fatty acid oxidation and glucose uptake [54,55].…”

Section: Adipocytokine Signaling Pathwaymentioning

confidence: 99%

RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Scatophagus argus)

Chen

Cai

Tian

et al. 2023

Animals

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Spotted scat (Scatophagus argus) can tolerate a wide range of salinity fluctuations. It is a good model for studying environmental salinity adaptation. Lipid metabolism plays an important role in salinity adaptation in fish. To elucidate the mechanism of lipid metabolism in the osmoregulation, the liver transcriptome was analyzed after 22 d culture with a salinity of 5 ppt (Low-salinity group: LS), 25 ppt (Control group: Ctrl), and 35 ppt (High-salinity group: HS) water by using RNA sequencing (RNA-seq) in spotted scat. RNA-seq analysis showed that 1276 and 2768 differentially expressed genes (DEGs) were identified in the LS vs. Ctrl and HS vs. Ctrl, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the pathways of steroid hormone biosynthesis, steroid biosynthesis, glycerophospholipid metabolism, glycerolipid metabolism, and lipid metabolism were significantly enriched in the LS vs. Ctrl. The genes of steroid biosynthesis (sqle, dhcr7, and cyp51a1), steroid hormone biosynthesis (ugt2a1, ugt2a2, ugt2b20, and ugt2b31), and glycerophospholipid metabolism (cept1, pla2g4a, and ptdss2) were significantly down-regulated in the LS vs. Ctrl. The pathways related to lipid metabolisms, such as fatty acid metabolism, fatty acid biosynthesis, peroxisome proliferator-activated receptor (PPAR) signaling pathway, adipocytokine signaling pathway, fatty acid degradation, and unsaturated fatty acid biosynthesis, were significantly enriched in the HS vs. Ctrl. The genes of unsaturated fatty acid biosynthesis (scd1, hacd3, fads2, pecr, and elovl1) and adipocytokine signaling pathway (g6pc1, socs1, socs3, adipor2, pck1, and pparα) were significantly up-regulated in the HS vs. Ctrl. These results suggest that the difference in liver lipid metabolism is important to adapt to low- and high-salinity stress in spotted scat, which clarifies the molecular regulatory mechanisms of salinity adaptation in euryhaline fish.

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Spexin acts as a novel glucose-lowering factor in grass carp (Ctenopharyngodon idella)

Zhang,

Wang,

Yang

et al. 2024

Biochemical and Biophysical Research Communications

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Adiponectin and adiponectin receptors in common carp (Cyprinus carpio): Tissue distribution and their expressions in response to high-carbohydrate and high-lipid diets

Cited by 3 publications

References 47 publications

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Scatophagus argus)

Spexin acts as a novel glucose-lowering factor in grass carp (Ctenopharyngodon idella)

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