Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma

Ermetici, Federica; Malavazos, Alexis Elias; Corbetta, Sabrina; Morricone, Lelio; Dall’Asta, Chiara; Corsi, Massimiliano M.; Ambrosi, Bruno

doi:10.1016/j.metabol.2006.12.018

Cited by 56 publications

(55 citation statements)

References 42 publications

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“…These results suggest that abundant noradrenaline is associated with Adp upregulation; however, the underlying mechanism is unclear. Ermetici et al 17) reported that adiponectin levels were significantly elevated in patients with adrenal incidentaloma; however, there is no evidence of adiponectin production at the adrenal level. Elevation of Adp, a key anti-diabetes adipokine, may protect against diabetes in individuals with NA-type pheochromocytomas.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Isobe

Tatsuno

et al. 2009

JAT

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Aim: Recent studies have demonstrated that serum adiponectin and its receptors in adipose and muscle tissues are suppressed in diabetic or obese individuals. Patients with pheochromocytoma are frequently diabetic. Methods: Using real-time PCR, we examined mRNA expressions of adiponectin (Adp) and adiponectin receptor 1 (AdpR1) and AdpR2 in pheochromocytoma tissues from 49 patients. We also measured levels of serum total and high molecular weight (HMW) adiponectin levels in 10 pheochromocytomas and 33 normal volunteers.

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Section: Discussionmentioning

confidence: 99%

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Isobe

Tatsuno

et al. 2009

JAT

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“…Of note, a recent paper evaluating adipokine levels in 20 patients with adrenal incidentaloma (of whom only 3 had subclinical CS) found higher TNF-␣ concentrations in these patients as compared with age-, sex-, and BMImatched controls, suggesting that adrenal tissue may autonomously produce TNF-␣ [108] .…”

Section: Tnf-␣ and Cushing's Syndromementioning

confidence: 93%

“…Nine months after surgery, there was no significant decrease in resistin concentrations, despite a significant reduction in total body fat and trunk fat [63] . Interestingly, Ermetici et al [108] reported significantly higher resistin levels in patients with adrenal incidentalomas as compared with controls.…”

Section: Resistin and Cushing's Syndromementioning

confidence: 99%

Adipokines and Cardiovascular Risk in Cushing’s Syndrome

et al. 2011

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Cushing’s syndrome (CS) is associated with increased cardiovascular morbidity and mortality. Recent evidence also suggests that increased cardiovascular risk may persist even after long-term remission of CS. Increased central obesity, a typical feature of CS, is associated with altered production of adipokines, which contributes to the pathogenesis of several metabolic and cardiovascular complications observed in this condition. In vitro and in vivo studies have shown a relationship between cortisol and adipokines in several experimental settings. In patients with either active or ‘cured’ CS, an increase in leptin and resistin levels as well as the release of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, may be associated with increased cardiovascular risk. For other adipokines, including adiponectin, results are inconclusive. Studies are needed to further elucidate the interactions between clinical and subclinical increases in cortisol production and altered adipokine release in CS.

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“…The presence of an AI has been associated with an increased incidence of several cardiovascular risk factors including high prevalence of obesity, hypertension, diabetes mellitus, glucose intolerance, and dyslipidemia (1)(2)(3)(4). However, despite well-known association of nonfunctional adrenal incidentaloma (NFA) with cardiovascular risk factors, the exact mechanism underlying this relationship has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Delibaşı

Karbek²,

Bozkurt

et al. 2015

Arch. Endocrinol. Metab.

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Objective: To evaluate circulating E-selectin levels in patients with nonfunctional adrenal incidentaloma (NFA) in relation to insulin resistance and early atherosclerosis. Subjects and methods: A total of 40 patients with NFA (mean [SD] age: 55.6 [10.7] years; 70% were females) and 35 controls (mean [SD] age: 51.5 [8.1] years; 71.4% were females) selected from age-, gender-and body mass index (BMI)-matched healthy subjects were enrolled. Serum hsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. High-resolution Bmode ultrasonography was performed. Serum levels of E-selectin were evaluated by enzyme-linked immunosorbent assay. Results: Patients with NFA had significantly higher values for E-selectin (14.9 (4.8) vs. 12.2 (4.1) ng/mL, p < 0.01) and CIMT (0.6 (0.1) vs. 0.5 (0.1) mm, p < 0.05) than controls. Serum E-selectin levels showed a statistically significant association with hsCRP (r = 0.751, p < 0.001), HOMA-IR (r = 0.575, p < 0.001) and CIMT (r = 0.762, p < 0.001). CIMT (Carotid intima media thickness) was increased in patients with NFA patients with NFA were more insulin resistant than controls and statistically significant relationship was found between size of tumor and HOMA-IR (r = 0.361, p < 0.001). Conclusion: In conclusion, based on significantly higher values for E-selectin, CIMT and HOMA-IR in patients with NFA than controls along with significant correlation of E-selectin levels to CIMT, HOMA-IR and hs-CRP, our findings seems to indicate an increased risk of early atherosclerosis and impaired endothelial function in NFA patients, particularly in case of insulin resistance. Arch Endocrinol Metab. 2015;59(4):310-7

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Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma

Cited by 56 publications

References 42 publications

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Adipokines and Cardiovascular Risk in Cushing’s Syndrome

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

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