Adipogenic commitment induced by green tea polyphenols remodel adipocytes to a thermogenic phenotype

Bolin, Anaysa Paola; Sousa-Filho, Celso Pereira Batista; Santos, Gustavo Tolentino Nascimento dos; Ferreira, Letícia Torres; Andrade, Paula Bresciani Martins de; Figueira, Ana Carolina Migliorini; Batista, Fernanda Aparecida Heleno; Otton, Rosemari

doi:10.1016/j.jnutbio.2020.108429

Cited by 13 publications

(8 citation statements)

References 43 publications

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“…AMPK can promote UCP-1 expression through downstream cascades [ 53 ], while PPARα acts as a transcription factor binding to the PPAR-responsive element to facilitate UCP-1 transcription and mitochondrial fatty acid oxidation [ 54 ]. Similar to previous studies, SO supplementation did not change the weight of BAT, but the weight of WAT decreased significantly ( Figure 5 C,D) [ 55 ]. This suggests that the SO activates thermogenesis through PPARα and AMPK-induced UCP-1 expression in WAT, thereby attenuating adipocyte hypertrophy and abnormal lipid accumulation.…”

Section: Discussionsupporting

confidence: 89%

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Zheng

Lee

et al. 2023

Antioxidants

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Obesity produces many health problems, including systemic oxidative stress. This study comprehensively investigated the effects of Sanguisorba officinalis L. extract (SO) as an antioxidant on abnormal lipid accumulation and oxidative stress in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice (n = 48). We evaluated the anti-adipogenic and antioxidant effects of SO on 3T3-L1 by cell viability, Oil red O staining, and NBT assays. The ameliorative effects of SO in HFD-induced C57BL/6J mice were investigated by measuring body weight, serum lipids, adipocyte size, hepatic steatosis, AMPK pathway-related proteins, and thermogenic factors. In addition, the effect of SO on oxidative stress in obese mice was evaluated by the activity of antioxidant enzymes and the production of lipid peroxidation products and ROS production in adipose tissue. We found that SO dose-dependently decreased lipid accumulation and ROS production in 3T3-L1 adipocytes. In C57BL/6J obese mice, SO (above 200 mg/kg) attenuated the HFD-induced gain in body weight and white adipose tissue (WAT) weight without affecting appetite. SO also decreased serum glucose, lipid, and leptin levels and attenuated adipocyte hypertrophy and hepatic steatosis. Furthermore, SO increased the expression of SOD1 and SOD2 in WAT, decreased ROS and lipid peroxides, and activated the AMPK pathway and thermogenic factors. In summary, SO reduces oxidative stress in adipose tissue by increasing antioxidant enzyme activity and improves obesity symptoms through AMPK-pathway-regulated energy metabolism and mitochondrial respiratory thermogenesis.

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Section: Discussionsupporting

confidence: 89%

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Zheng

Lee

et al. 2023

Antioxidants

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“…Previous studies have shown that antiadiposity is associated with reduced expression of several inflammatory markers (Cunha et al., 2013 ; Sae‐Tan et al., 2015 ), which is consistent with our results. A recent study reported that green tea may involve the PPARγ/FGF21/AMPK/UCP‐1 pathway, promoting the induction of thermogenic cells by reprogramming the initial steps of adipocyte commitment (Bolin, Sousa‐Filho, dos Santos, et al., 2020 ). In this study, we show that GTAE induces browning markers in Ing‐WAT.…”

Section: Discussionmentioning

confidence: 99%

Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning

Chen

Zhai

et al. 2021

Food Science & Nutrition

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The global prevalence of overweight and obesity has increased markedly, and obesity has become a serious health concern (Afshin et al., 2017). Moreover, obesity is a risk factor for the development of many diseases, including type-2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease, and several cancer types among others (Hruby & Hu, 2015;Ren et al., 2021). Emerging evidence suggests the occurrence of pathogenic events in the development and progression of obesity-associated comorbidities, including lowgrade systemic inflammation, oxidative stress, and insulin resistance (Hernandez-Bautista et al., 2019;Romeo et al., 2012). Therefore, it is critical to investigate the physiological mechanisms during the occurrence and development of obesity.In mammals, brown adipose tissue (BAT) is metabolically highly active and dissipates energy as heat through nonshivering thermogenesis (Cannon & Nedergaard, 2004). In addition, BAT is a multilocular organ that contains a relatively large number of mitochondria that produce heat via uncoupling of the respiratory chain (Poekes et al., 2015). BAT maintains temperature in newborn infants and small mammals (McMillan & White, 2015). Recent studies have demonstrated that adults also possess metabolically active brown fat or "beige adipocyte" (browning of white adipose

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“…The consumption of green tea or its components, green tea catechins, have been reported to be able to increase fat oxidation and energy expenditure along with upregulated UCP1 expression in rat BAT, suggesting that suppressive effect of catechins on body fat accumulation is associated with increased BAT activity [ 135 ]. Catechins in green tea could facilitate noradrenaline and ADRB3 signaling activation and subsequently stimulate thermogenesis and fat oxidation in mice [ 136 , 137 ]. However, thermogenic activation by green tea catechins remains controversial in humans.…”

Section: Food-derived Stimulants and Diet-induced Bat Thermogenesismentioning

confidence: 99%

The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases

Chan

Hsieh

2022

IJMS

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Brown adipose tissue (BAT) has been considered a vital organ in response to non-shivering adaptive thermogenesis, which could be activated during cold exposure through the sympathetic nervous system (SNS) or under postprandial conditions contributing to diet-induced thermogenesis (DIT). Humans prefer to live within their thermal comfort or neutral zone with minimal energy expenditure created by wearing clothing, making shelters, or using an air conditioner to regulate their ambient temperature; thereby, DIT would become an important mechanism to counter-regulate energy intake and lipid accumulation. In addition, there has been a long interest in the intriguing possibility that a defect in DIT predisposes one to obesity and other metabolic diseases. Due to the recent advances in methodology to evaluate the functional activity of BAT and DIT, this updated review will focus on the role and regulatory mechanism of BAT biology in DIT in health and diseases and whether these mechanisms are applicable to humans.

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Adipogenic commitment induced by green tea polyphenols remodel adipocytes to a thermogenic phenotype

Cited by 13 publications

References 43 publications

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning

The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases

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