Adipocytokines as Influenced by Family History of Type 2 Diabetes and Smoking in Non-Diabetic Subjects

Abstract

Background: The controversial roles played by major adipocytokines such as resistin, leptin and adiponectin in obesity and insulin resistance were extensively studied. This study aims to explore for the fi rst time the possible effect of a family history of type 2 diabetes mellitus and smoking on non-diabetic individuals and associations to other metabolic parameters.

Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances

“…1) and strengthened from multivariate analysis, where VAI was the only significant determinant factor of adiponectin levels, which is expressed and secreted from adipose tissue and acts as an insulin-sensitizing agent. This molecule constitutes a key-player in the development of cardiovascular incidents, because it is the only known protective adipokine with anti-diabetogenic, anti-inflammatory and anti-atherogenic properties [23][24][25][26]. The fact that VAI is related only with adiponectin values and not the other adipokines studied (leptin, TNF-a and resistin) and subclinical inflammation index hsCRP is of great value.…”