Adiabatic magnetothermia makes possible the study of the temperature dependence of the heat dissipated by magnetic nanoparticles under alternating magnetic fields

Natividad, Eva; Castro, Miguel; Mediano, Arturo

doi:10.1063/1.3600633

Cited by 39 publications

(24 citation statements)

References 18 publications

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“…Clearly, calorimetry-based methods are not suitable to measure the temperature dependence of SAR values. The thermal dependence can be measured only when the setup is perfectly adiabatic [171,172]. In this case, the slope corresponds to the initial time slope in Eqs.…”

Section: When Dealing With Large Sample Volumes With High Heat Dissipmentioning

confidence: 99%

Fundamentals and advances in magnetic hyperthermia

Périgo

Hemery

Sandre

et al. 2015

Applied Physics Reviews

673

526

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Nowadays, magnetic hyperthermia constitutes a complementary approach to cancer treatment. The use of magnetic particles as heating mediators, proposed in the 1950s, provides a novel strategy for improving tumor treatment and, consequently, patient quality of life. This review reports a broad overview about several aspects of magnetic hyperthermia addressing new perspectives and the progress on relevant features such as the ad hoc preparation of magnetic nanoparticles, physical modeling of magnetic heating, methods to determine the heat dissipation power of magnetic colloids including the development of experimental apparatus and the influence of biological matrices on the heating efficiency.Comment: 104 pages, 28 figures. Manuscript accepted for publication in Applied Physics Review

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Section: When Dealing With Large Sample Volumes With High Heat Dissipmentioning

confidence: 99%

Fundamentals and advances in magnetic hyperthermia

Périgo

Hemery

Sandre

et al. 2015

Applied Physics Reviews

673

526

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“…Only when the sample holder is quasi-adiabatic and the surrounding temperature is properly controlled, it is possible to obtain the initial time slope in equation (1) at different temperatures. Natividad et al measured by these means temperature-dependent SAR of commercial magnetite [8] and manganite perovskite [9] nanoparticles respectively in the 120 -250 and 253 -343 K temperature ranges, i.e. around the blocking temperature T B for iron oxide and near to the Curie temperature T C for manganite.…”

Section: Introductionmentioning

confidence: 99%

Specific absorption rate dependence on temperature in magnetic field hyperthermia measured by dynamic hysteresis losses (ac magnetometry)

Garaio¹,

Sandre

Collantes³

et al. 2014

Nanotechnology

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Magnetic nanoparticles (NPs) are intensively studied for their potential use for magnetic hyperthermia, a treatment that has passed a phase II clinical trial against severe brain cancer (glioblastoma) at the end of 2011. Their heating power, characterized by the 'specific absorption rate (SAR)', is often considered temperature independent in the literature, mainly because of the difficulties that arise from the measurement methodology. Using a dynamic magnetometer presented in a recent paper, we measure here the thermal dependence of SAR for superparamagnetic iron oxide (maghemite) NPs of four different size-ranges corresponding to mean diameters around 12 nm, 14 nm, 15 nm and 16 nm. The article reports a parametrical study extending from 10 to 60 °C in temperature, from 75 to 1031 kHz in frequency, and from 2 to 24 kA m(-1) in magnetic field strength. It was observed that SAR values of smaller NPs decrease with temperature whereas for the larger sample (16 nm) SAR values increase with temperature. The measured variation of SAR with temperature is frequency dependent. This behaviour is fully explained within the scope of linear response theory based on Néel and Brown relaxation processes, using independent magnetic measurements of the specific magnetization and the magnetic anisotropy constant. A good quantitative agreement between experimental values and theoretical values is confirmed in a tri-dimensional space that uses as coordinates the field strength, the frequency and the temperature.

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“…For example, it is well-known that the thermal dependence of the out-of-phase ac magnetic susceptibility, χ″, provides useful information of certain magnetic transitions. At low H 0 values, where the linear response theory [6] is fulfilled, SAR is linearly proportional to χ″, thus providing similar information [7], but obtained with f and H 0 values more adequate for magnetic hyperthermia.…”

Section: Introductionmentioning

confidence: 84%

“…The thermal evolution of ΔT was measured using a unique special-purpose magnetothermal setup working in adiabatic conditions, and following the procedure described elsewhere [7]. In the present case, the temperature of the specimens was first decreased down to ca.…”

Section: Measurement Of Heating Abilitymentioning

confidence: 99%