Fundamentals and advances in magnetic hyperthermia

Périgo, E.A.; Hemery, Gauvin; Sandre, Olivier; Ortega, Daniel; Garaio, Eneko; Plazaola, F.; Terán, F.J. Díaz de

doi:10.1063/1.4935688

Cited by 699 publications

(595 citation statements)

References 227 publications

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“…(2) gives the same results as the corrected slope method described in section 2. That means that we deal with conventional magnetic heating far from the blocking temperature, Curie point and other self-regulated mechanisms limiting the maximum temperature [2]. It should be noted that the values of SAR was calculated per unit of mass of the sample (magnetic part and the polymer coating) so they cannot be used for comparison of heating ability of bare magnetite nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

“…Heating of MNp in alternating (AC) magnetic field leads to the therapeutic effect either through direct thermal treatment [1,2] or due to the heat-assisted release of the drug carried by nanoparticles [3]. The magnetically functionalized implants, which consist of polymeric matrices and MNp, can also be used as effective method to prevent undesired effect of inflammation or cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

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Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

et al. 2018

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Heating of the magnetic nanoparticles in AC magnetic field is the effect promising for application in medicine. The mechanisms of heating in AC-magnetic field implies nontrivial dependence of the power dissipated by magnetic nanoparticles on frequency. With the use of a reconfigurable experimental setup, this frequency-dependent magnetic heating was measured on two characteristic examples: the magnetite nanoparticles conventionally used in medicine and polymer coating with micrometer sized magnetite particles. The saturation of the heating power with frequency is shown that is more pronounced for the second case of microparticles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

et al. 2018

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“…Magnetic nanoparticles (MNPs) synthesized by various chemical routes are studied for their potential use in medicine, in particular for magnetic hyperthermia [16,17]. In this work, MNPs were synthesized by alkaline co-precipitation of ferrous and ferric salts followed by size sorting procedure as previously described [18].…”

Section: Mtn Synthesis and Characterizationmentioning

confidence: 99%

In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

Sandre¹,

Genevois²,

Garaio³

et al. 2017

Preprint

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Abstract:The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and non-invasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected sub-cutaneously with Matrigel™ to generate so called pseudo tumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 hours after heating. We showed that dextran-coated magnetic iron oxide nanoparticles dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as non-invasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.

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“…The realization of this scenario corresponds to an ideal therapy, and thus complete body magnetic fluid hyperthermia cancer therapy is intensively investigated by previous studies as an option in new cancer treatments to replace surgery, radiation therapy, and chemotherapy [1][2][3][4][5][6][7][8]. However, the selective annihilation of cancer cells, leaving the normal cells safe, is debatable since normal tissues are also warmed up due to eddy current loss.…”

Section: Introductionmentioning

confidence: 99%

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

Mamiya

Takeda

Naka

et al. 2017

Journal of Nanomaterials

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Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude ac for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency of 25 kHz. The limit corresponds to the value ac of 2.5 × 10 6 Oe⋅s −1 and is significantly lower than the conventionally accepted criteria of 6 × 10 7 Oe⋅s −1 . The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.

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Fundamentals and advances in magnetic hyperthermia

Cited by 699 publications

References 227 publications

Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

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