Abstract:Chief enantiomer in breast tumors is D-2HG. Mitochondrial Alcohol Dehydrogenase (ADHFE I ) produces D-2HG. lt is the CA breast oncogene which leads to decreased patient survival. c-MYC can upregulate ADHFE I by changes in iron metabolism whereas co expression of c-MYC and ADHFE I greatly augment ort hotopic growth of tumor in MCF7 cells. Aims: To determine the expression levels and localization of c-M yc and ADHFE I in different stages of breast cancer tissue. Study Design: Cross-sectional comparative study. M… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.