Adhesion study of cultured human lens capsule cells on hydrophilic intraocular lenses coated with polyethylene glycol

Viveiros, Magda Massae Hata; Soares, Ricardo Torres; Omodei, Michelle Sako; Rainho, Cláudia Aparecida; Padovani, Carlos Roberto; Cruz, Nilson Cristino da; Schellini, Silvana Artioli; Rodrigues, Antônio Carlos Lottelli

doi:10.1016/j.jcrs.2014.11.047

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…For example, treating IOL surface with plasma or immobilizing with heparin, poly(ethylene glycol), or phosphorylcholine can reduce the bioadhesion better than coating with inert materials. [11][12][13][14][15][16] However, bioadhesion can still be found on coated hydrophilic surfaces, which may be due to the undesired surface coating by common hydrophilic molecules. A more effective antifouling coating is essential for IOL surface modifications.…”

Section: Introductionmentioning

confidence: 99%

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Han¹,

Xu²,

Tang³

et al. 2016

IJN

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Section: Introductionmentioning

confidence: 99%

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Han¹,

Xu²,

Tang³

et al. 2016

IJN

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“…16,17 Subsequent investigations show that the surface hydrophilic modification can effectively resist the bioadhesion, such as surface treated with plasma or immobilized with heparin, poly(ethylene glycol) (PEG), or phosphorylcholine (PC). [18][19][20][21][22][23] The hydrophilic modification of the IOL decreases the LEC adhesion and proliferation effectively. However, most of these researches mainly focused on the in vitro cell response.…”

Section: Introductionmentioning

confidence: 99%

Surface PEGylation of intraocular lens for PCO prevention: An in vivo evaluation

Tang

Han

et al. 2016

J Biomater Appl

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Posterior capsular opacification (PCO) is a common complication in cataract surgery. The development of PCO is attributed to the combination of adhesion, migration, proliferation, and transdifferentiation of the residual lens epithelial cells (LEC) onto the interface of intraocular lens (IOL) material and lens posterior, in which the initial adhesion is the beginning step and plays important roles. In the present study, hydrophilic polyethylene glycol (PEG) was immobilized onto IOL surface via plasma-aided chemical grafting procedure. The attenuated total reflection - Fourier transform infrared (ATR-FTIR) and contact angle (CA) - measurements indicate the successful surface PEGylation, as well as the excellent hydrophilicity of the surfaces. Compared with pristine IOL, the PEGylation does not influent its optical property, whereas the initial adhesion of LEC is greatly inhibited. In vivo ocular implantation results show that the PEGylated IOL presents good in vivo biocompatibility, and can effectively prevent the PCO development.

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Restructuration kinetics of amphiphilic intraocular lenses during aging

Tortolano

Saunier

Hammami

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Adhesion study of cultured human lens capsule cells on hydrophilic intraocular lenses coated with polyethylene glycol

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 4 publications

References 24 publications

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Surface PEGylation of intraocular lens for PCO prevention: An in vivo evaluation

Restructuration kinetics of amphiphilic intraocular lenses during aging

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