Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. II.

Elkins, Thomas E.; Bury, Robert J.; Ritter, Jack L.; Ling, Frank W.; Ahokas, Robert A.; Homsey, Charles A.; Malinak, L. Russell

doi:10.1016/s0015-0282(16)47910-0

Cited by 68 publications

(32 citation statements)

References 8 publications

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“…The present findings are consistent with the study conducted on rabbits by Fred ericks et al [14]. In the study by Elkins et al [ 15] conducted on rats, the incidence of adhe sions was much lower when 1 % SCMC was used as opposed to other separating agents.…”

supporting

confidence: 93%

Effect of Sodium Carboxymethylcellulose on Post-Operative Peritoneal Adhesion Formation in Rabbits

Aly

Darwish²,

Bayomi

et al. 1994

Med Princ Pract

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Thirty non-pregnant female albino rabbits of the blanc du Bouscat strain were selected for this study. Laparotomies were performed on the animals. Both uterine horns of each animal were transected, then repaired by end-to-end anastomosis. Before closing the abdomen, 1% sodium carboxymethylcellulose (SCMC), 7 ml/kg body weight, was instilled in 20 animals (study group) and dextran 70, 7 ml/kg body weight, was instilled in the remaining 10 animals (control group). Two weeks later, the animals were re-explored and adhesion formations were assessed. It was found that SCMC reduced adhesion formation in the treated animals more than dextran 70.

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supporting

confidence: 93%

Effect of Sodium Carboxymethylcellulose on Post-Operative Peritoneal Adhesion Formation in Rabbits

Aly

Darwish²,

Bayomi

et al. 1994

Med Princ Pract

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“…A literatura apresenta trabalhos controversos, com resultados diferentes dos nossos. Graebe et al 10 , em estudo realizado em ratas, encontraram 53% de animais sem aderência (escore 0), 7% com aderências leves (escores 1+ e 2+) e 33% com aderências graves (escores 3+ e 4+), o que se demonstrou de modo semelhante nos trabalhos de Elkins et al 12 . O dextrano 70 a 32% tem sido descrito como substância capaz de prevenir a formação de aderências por dois mecanismos: a hidroflotação, por meio da separação mecânica das superfícies peritoneais lesadas, e a inibição química pela diminuição da deposição de fibrina (siliconização) 11,23 .…”

Section: Discussionunclassified

“…Entretanto, minimizar sua formação secundária à laparotomia, empregando-se cuidados e técnicas cirúrgi-cas minimamente invasivas, é consenso atualmente 8,9 . Dentre as modalidades profiláticas mais utilizadas experimentalmente estão as aplicações intraperitoneais de: dextrano 70 a 32% 10,11 , carboximetilcelulose 10,12 , corticóides 11 e antihistamínicos 13 . O uso profilático (pré e pós-operatório) de antibióticos de amplo espectro é recomendado 8,9 , e o estímulo precoce da motilidade intestinal contribui para a profilaxia de aderências.…”

Section: Introductionunclassified

Prevenção de aderências pélvicas: estudo experimental em ratas com diferentes modalidades terapêuticas

Pacheco¹,

Dias²,

Silva³

et al. 2003

Rev. Bras. Ginecol. Obstet.

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“…Unkontrollierte, manuelle Traumatisierung durch Quetschung und Abschabung der Darmserosa sowie subjektive Beurteilung des Verwachsungsumfanges, wenn auch zum Teil durch Klassifikation des AdhfisionsausmaBes und Einsch/itzung durch mehrere Beobachter verbessert, k6nnen keine wissenschaftliche Basis ffir klinisches Handeln darstellen [2,3,4,15,19]. Zudem dfirften Substanzen mit bekannt hoher Nebenwirkungsrate wie Antirheumatica, Cortison oder Colchicin keine allgemeine Akzeptanz zur Prophylaxe finden [5,18].…”

Section: Diskussionunclassified

Postoperative, intraabdominelle Adh�sionen ?Ein neues standardisiertes und objektiviertes Tiermodell und Testung von Substanzen zur Adhasionsprophylaxe

Treutner

Winkeltau

Lerch

et al. 1989

Langenbecks Arch Chiv

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80 male Sprague Dawley rats were divided in 8 groups of equal size. After median laparotomy defined abrasions of the serosa of abdominal wall, cecum and ileum were performed (400p, abrasive paper 280 grains/cm2, 8 cm2). The control group (I) received no medication. In the treatment groups 5 ml of the following agents were instilled before closure of the abdominal wall: normal saline (II), 16,250 IE Neomycin with 1250 IE Bacitracin (III), 30% dextrose (MW 70,000) (IV), 50,000 IE Streptokinase with 12,500 IE Streptodornase (V), or TCDO in concentrations of 10% (VI), 50% (VII), and 100% (VIII). All animals were relaparotomized on the 7th postoperative day, the adhesions were dissected and their extent was calculated by computer aid. Furthermore specimens were obtained for microscopic studies. Compared to the controls no reduction of adhesions could be achieved by dextrose. Significantly more adhesions were observed after treatment with Neomycin/Bacitracin. A reduction of about 23% was registered with normal saline and TCDO 10%. The greatest reduction of adhesions was seen after application of Streptokinase/Streptodornase as well as TCDO in concentrations of 50% and 100% (63%). The results were significant after evaluation with the t-test. Histologically there was a correlation between the extent of adhesions and the fibrin film. The new animal model has proven to result in reproducible data if used to evaluate substances for prevention of adhesions. Clinical studies with the best of these agents could serve as an approach to solve the problem of adhesion ileus.

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Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. II.

Cited by 68 publications

References 8 publications

Effect of Sodium Carboxymethylcellulose on Post-Operative Peritoneal Adhesion Formation in Rabbits

Effect of Sodium Carboxymethylcellulose on Post-Operative Peritoneal Adhesion Formation in Rabbits

Prevenção de aderências pélvicas: estudo experimental em ratas com diferentes modalidades terapêuticas

Postoperative, intraabdominelle Adh�sionen ?Ein neues standardisiertes und objektiviertes Tiermodell und Testung von Substanzen zur Adhasionsprophylaxe

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