Adhesion of Poly(lactide-glycolide) Coating (PLGA) on the Ti6Al7Nb Alloy Substrate

Szewczenko, Janusz; Kajzer, W.; Kajzer, Anita; Basiaga, Marcin; Kaczmarek, Marcin; Major, R.; Simka, Wojciech; Jaworska, Joanna; Jelonek, Katarzyna; Karpeta-Jarząbek, Paulina; Kasperczyk, Janusz

doi:10.1007/978-3-030-23762-2_51

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…The microscopic observations of the samples’ surfaces showed that both types of polymer coatings were characterized by transparency, continuity, and homogeneity ( Figure 1 ). Similar features of polymer coatings, but with different chemical compositions, applied with the dip-coating method on a substrate made with metal biomaterials have been shown by authors in their earlier works [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultssupporting

confidence: 55%

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

et al. 2021

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In this study, we aimed to determine the effect of long-term exposure to artificial urine on the physical properties of CoCrMo alloy with biodegradable heparin-releasing polymeric coatings. Variants of polymer coatings of poly(L,L-lactide-ɛ-caprolactone) (P(L,L-L/CL)) and poly(D,L-lactide-ɛ-caprolactone) (P(D,L-L/CL)) constituting the base for heparin-releasing (HEP) polyvinyl alcohol (PVA) coatings were analyzed. The coatings were applied by the dip-coating method. Heparin was used to counteract the incrustation process in the artificial urine. The study included tests of wettability, resistance to pitting and crevice corrosion, determination of the mass density of metal ions penetrating into the artificial urine, and the kinetics of heparin release. In addition, microscopic observations of surface roughness and adhesion to the metal substrate were performed. Electrolytically polished CoCrMo samples (as a reference level) and samples with polymer coatings were used for the tests. The tests were conducted on samples in the initial state and after 30, 60, and 90 days of exposure to artificial urine. The analysis of the test results shows that the polymer coatings contribute by improving the resistance of the metal substrate to pitting and crevice corrosion in the initial state and reducing (as compared with the metal substrate) the mass density of metal ion release into the artificial urine. Moreover, the PVA + HEP coating, regardless of the base polymer coatings used, contributes to a reduction in the incrustation process in the first 30 days of exposure to the artificial urine.

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Section: Resultssupporting

confidence: 55%

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

et al. 2021

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“…This proved that the applied polymer coatings constituted a protective barrier that limited the release of the degradation products of the metal substrate into the Ringer's solution. Preliminary studies of the authors showed a beneficial effect of reducing the mass density of metal ions by biodegradable polymer coatings, which were applied on stainless steel Ti6Al4V and Ti6Al7Nb alloys; however, the applied surface treatment parameters were different than the ones used in the present study [39,47,48]. In the previous work, concerning the PLGA coating (10% w/w) [48], the influence of the number of dips in the process of applying polymer coatings on the mass density of ions releasing into the solution was also observed.…”

Section: Biological Test Resultsmentioning

confidence: 99%

“…Preliminary studies of the authors showed a beneficial effect of reducing the mass density of metal ions by biodegradable polymer coatings, which were applied on stainless steel Ti6Al4V and Ti6Al7Nb alloys; however, the applied surface treatment parameters were different than the ones used in the present study [39,47,48]. In the previous work, concerning the PLGA coating (10% w/w) [48], the influence of the number of dips in the process of applying polymer coatings on the mass density of ions releasing into the solution was also observed. In this work, we decided to choose a less-concentrated solution of PLGA-1% to be used for coating preparation in order to verify whether it provid-es the same effect of limiting metal ions.…”

Section: Biological Test Resultsmentioning

confidence: 99%

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

et al. 2020

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The inhibition of the corrosion of metal implants is still a challenge. This study aimed to increase the corrosion resistance of Ti6Al7Nb alloy implants through surface modification, including grinding, sandblasting, and anodic oxidation followed by the deposition of a polymer coating. The aim of the work was to determine the influence of biodegradable polymer coatings on the physico-chemical properties of a Ti6Al7Nb alloy used for short-term implants. Biodegradable coatings prepared from poly(glycolide-caprolactone) (P(GCap)), poly(glycolide ε-caprolactone-lactide) (P(GCapL)), and poly(lactide-glycolide) (PLGA) were applied in the studies. The dip-coating method with three cycles of dipping was applied. Corrosion resistance was assessed on the basis of potentiodynamic studies. The studies were carried out on samples after 30, 60, and 90 days of exposure to Ringer's solution. Surface topography, wettability, and cytotoxicity studies were also carried out. The degradation process of the base material was evaluated on the basis of the mass density of the metal ions released to the solution. The results indicated the influence of the coating type on corrosion resistance. In addition, a beneficial effect of the polymer coating on the reduction of the density of the released metal ions was found, as compared to the samples without polymer coatings. The obtained results provide basic knowledge for the development of polymer coatings enriched with an active substance. The presence of ciprofloxacin in the coating did not reduce the corrosion resistance of the metal substrate. Moreover, the cytotoxicity test using the extract dilution method demonstrated that the implants' coatings are promising for further in vitro and in vivo studies.The extensive use of biodegradable polymers in medical applications is mainly associated with the possibility of tailoring their physicochemical and mechanical properties. Controlled polymer degradation allows for their use as carriers of medicinal substances, ensuring drug release with regulated dynamics to obtain the expected therapeutic effects [5]. The mentioned group of biopolymers is characterized by an appropriate biocompatibility [4], and the achieved degradation products-mainly lactic, glycolic, and hydroxyhexanoic acids-are found to be neutral to the human organism and are metabolized in accordance the Krebs cycle [6]. The basic limitation of the use of biodegradable polymers relates to the mechanical properties that change over time. This feature may be disadvantageous in some applications, e.g., orthopedic implants. Treatment disorders can be observed as the implant weakens due to degradation processes. This can lead to repeated injuries. The consequence of this is the need to perform a revision surgery combined with the removal of an incompletely degraded and mechanically weakened implant and followed by its replacement with a new one. The revision surgery due to the progressive degradation of the polymer material may be associated with serious difficulties that lead to a much ...

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“…Sandblasting can increase the surface development significantly, which can have an influence on the adhesion of the additional coatings formed on a modified metal substrate. During our previous study, the highest adhesion of PLGA coatings deposited on Ti6Al7Nb alloy was noted for samples subjected to sandblasting (Szewczenko et al, ).…”

Section: Introductionmentioning

confidence: 79%

“…The reason that contributed to the satisfactory polymer layer adhesion was the developed process of surface modification of the Ti6Al7Nb (Figure ), which was presented in detail in the previous works (Marciniak, Szewczenko, & Kajzer, ; Szewczenko, Marciniak, Tyrlik‐Held, & Nowinska, ; Szewczenko, Nowinska, & Marciniak, ). Our parallel study (Szewczenko et al, ) used acoustic microscopy and scratch test analysis to characterize the influence of the surface topography of the Ti6Al7Nb alloy on the adhesion of the PLGA coating. It confirmed that polymer coating had good adhesion to the alloy.…”

Section: Discussionmentioning

confidence: 99%

Development of antibacterial, ciprofloxacin‐eluting biodegradable coatings on Ti6Al7Nb implants to prevent peri‐implant infections

Jaworska

Jelonek

Jaworska-Kik

et al. 2020

J Biomedical Materials Res

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Various types of biodegradable polymers containing lactide, glycolide, caprolactone, and trimethylene carbonate units have been used to obtain ciprofloxacin (CFX)enriched coatings developed on the Ti6Al7Nb alloy, intended for short-term therapy.In the first step, the surface of the Ti6Al7Nb alloy was modified, mostly according to sandblasting and anodic oxidation to obtain the TiO 2 layer. Anodizing can be an effective method for preparing TiO 2 coatings with osteoconductive properties. The polymer containing CFX molecules was deposited on the modified alloy, and Polymer + CFX/TiO 2 /Ti6Al7Nb systems were developed. CFX-enriched coatings adhered well to the surface of the previously modified alloy. Polymer layers maintain the topography of the alloy due to the development of the surface during the sandblasting method. As polymers intended for the study possess degradation ability, they are capable of releasing the incorporated drug. Antibacterial activity of CFX-enriched coatings was examined to verify the functionality of designed Polymer + CFX/TiO 2 / Ti6Al7Nb systems, and the bactericidal effect was confirmed for all cases. The presented study is an extension of previous, initial research and creates an overview of polyester or polyestercarbonate CFX-eluting coatings. K E Y W O R D Sciprofloxacin, drug delivery, implants, polyester, Ti6Al7Nb

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Adhesion of Poly(lactide-glycolide) Coating (PLGA) on the Ti6Al7Nb Alloy Substrate

Cited by 7 publications

References 10 publications

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

Electrochemical and Biological Performance of Biodegradable Polymer Coatings on Ti6Al7Nb Alloy

Development of antibacterial, ciprofloxacin‐eluting biodegradable coatings on Ti6Al7Nb implants to prevent peri‐implant infections

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