Adhesion and Proliferation of Osteoblast-Like Cells on Anodic Porous Alumina Substrates With Different Morphology

Salerno, Marco; Caneva-Soumetz, F.; Pastorino, Laura; Patra, Nihar Ranjan; Diaspro, Alberto; Ruggiero, Carmelina

doi:10.1109/tnb.2013.2257835

Cited by 37 publications

(23 citation statements)

References 14 publications

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“…In contrast, cell functionality was fostered on membranes with small pore diameters of around 50 nm [21]. These results agree with the results obtained using 50-150 nm PAA and NIH-3T3 fibroblast cells [22], 20-200 nm pore size alumina and human osteoblast-like MG63 cells [23], and 75-300 nm pore size alumina and NIH 3T3 cells [24].…”

Section: Cell Growthsupporting

confidence: 90%

Mesoporous alumina as a biomaterial for biomedical applications

Xifré-Pérez

Ferre-Borull

Pallarès

et al. 2015

Open Material Sciences

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Porous anodic alumina (PAA) is a biomaterial based on a cost-effective electrochemical anodization of pure aluminum with unique geometrical properties, i.e., self-ordering hexagonal pore distribution, tunable pore diameters and interpore distances, and uniformity of the pores in the vertical direction (nanochannels). These remarkable properties have found important applications in several fields such as energy storage, optics, photonics, magnetism, catalysis and, in particular, in the biomedicine field. In this work, we review the current state of research and key issues on cell culture and implants, drug delivery systems with complex release profiles and specific action, and high efficiency and sensitivity biosensors with different biosensing mechanisms, all of them based on PAA. The biocompatibility, morphology of the surface, nanoestructural engineering in-depth, surface functionalization and coatings are discussed and analyzed in detail.

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Section: Cell Growthsupporting

confidence: 90%

Mesoporous alumina as a biomaterial for biomedical applications

Xifré-Pérez

Ferre-Borull

Pallarès

et al. 2015

Open Material Sciences

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“…The possibility to control the pore size and density, the biocompatibility and the mechanical and chemical stability, make APA a promising candidate for applications both in orthopedic and dental implants [39][40][41] as well as in bio-sensing [42][43][44][45]. It is widely recognized that surface morphology and roughness play an important role in the adhesion and proliferation of cells [1, [46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Thin nanoporous alumina-based SERS platform for single cell sensing

Toccafondi

Rocca

Scarpellini

et al. 2015

Applied Surface Science

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“…For APA, which has already been widely tested in the literature for biocompatibility with different cellular types (Poinern et al, 2011;Salerno et al, 2013;Toccafondi et al, 2014), loading of the pores has already been demonstrated with bioactive materials such as peptides (Swan et al, 2005), remineralization ions (Okawa et al, 2009), or antibacterial nanoparticles (Thorat et al, 2013a,b). In the latter work, the APA was loaded with nanoparticles of silver (see Figures 6A,B), which is a well-known biocide.…”

Section: Implant Surface Functionalizationmentioning

confidence: 99%

Dentistry on the Bridge to Nanoscience and Nanotechnology

Salerno

Diaspro

2015

Front. Mater.

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Dentistry is the area of medical sciences that is most resistant to the introduction of the novel methods arisen from the development of nanoscience and nanotechnology in the last 20 years. Without moving on to science-fiction-like views pointing to times far ahead in the future, we show that the available nanoscale devices and processes of current science and technology, partly inherited from the areas of microscopy and microelectronics, have already proven to be useful for research and development in different fields of dental research. To this goal, we review some results obtained in the last few years at our Institute in the area of dental materials and their characterization, which showed successful application of our background in microscopy and nanoengineering.Keywords: dental materials, microscopy, surface roughness, nanofabrication, resin composites, implants THE BROAD SCOPE OF DENTISTRYDentistry is considered to be a branch of medicine, such as orthopedics or physiology or neurology. In fact, while based on common foundations of medicine, dentistry is a large stand-alone area, which has its own grasps to the different fields mentioned above (American Dental Association, 2014). For example, topics of periodontal ligament health and dental implant osteointegration clearly relate to a peculiar "dental orthopedics"; the fact that teeth are not a mineralized appendix but rather a living organ in a living environment (gingiva, oral liquids) involves a specific "dental physiology"; the sensitivity of the living tooth, in connection with the pulp and related nerves, can be associated to a possible "dental neurology." Indeed, the oral environment, which is the place where dental functions are operated, is one of the most complex ones in the human body.As a result, within the dental area several specialized disciplines exist (see Figure 1). Conservative dentistry aims to maintain the original denture and largely overlaps with restorative dentistry, the latter encompassing prosthodontics, periodontics, and endodontics. Prosthodontics (or prosthetic dentistry) is required in case of massive irreversible tooth damage that cannot be fixed with simple resin composite filling, and requires the use of prosthesis for teeth, namely crowns, bridges, and even whole dentures. Periodontics (or periodontology) addresses the diseases of the periodontum, i.e., the teeth ligaments. Endodontics focuses on therapy of the root canals and connected pulp diseases. Oral surgery relates to the extraction of teeth that cannot be saved anymore and should be replaced by implants, and is usually combined with maxillo-facial surgery, extending the treated area around the denture. Prosthodontics, periodontics, and surgery correlate to implantology, which deals with the installation of dental implants. Orthodontics concerns the alignment and straightening of teeth, as well as fixing midface and mandibular growth issues. Pedodontics (or pediatric dentistry) relates to the specific dental issues of children's temporary dentures. Of course, oral...

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Adhesion and Proliferation of Osteoblast-Like Cells on Anodic Porous Alumina Substrates With Different Morphology

Cited by 37 publications

References 14 publications

Mesoporous alumina as a biomaterial for biomedical applications

Mesoporous alumina as a biomaterial for biomedical applications

Thin nanoporous alumina-based SERS platform for single cell sensing

Dentistry on the Bridge to Nanoscience and Nanotechnology

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