Adherence to bovine neutrophils and suppression of neutrophil chemiluminescence by Mycoplasma bovis

Thomas, Chester B.; Ess, P. Van; Wolfgram, L.J.; Riebe, J.; Sharp, Pamela B.; Schultz, R D

doi:10.1016/0165-2427(91)90032-8

Cited by 58 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lesion of caseous necrosis implies that the leukocytes are killed by this process, although previous in vitro studies do not indicate that M. bovis directly kills neutrophils or macrophages. 10,35 Thus, the pathogenesis of the leukocyte necrosis in this lesion remains an enigma.…”

Section: Discussionmentioning

confidence: 99%

“…4,31,33 Mycoplasma bovis has the ability to undergo antigenic variation by phenotypic alteration of the immunodominant surface lipoproteins 5,15,26 and modulates the host immune response. 11,35,37,38 In addition, M. bovis can adhere to, invade, and survive in epithelial and inflammatory cells. 1,10,34,35 These characteristics can facilitate the persistence of M. bovis and the development of chronic pneumonia in the face of an immune response and prolonged antibiotic therapy.…”

Section: Introductionmentioning

confidence: 99%

“…11,35,37,38 In addition, M. bovis can adhere to, invade, and survive in epithelial and inflammatory cells. 1,10,34,35 These characteristics can facilitate the persistence of M. bovis and the development of chronic pneumonia in the face of an immune response and prolonged antibiotic therapy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Naturally OccurringMycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Gagea¹,

et al. 2006

View full text Add to dashboard Cite

Abstract. Mycoplasma bovis is perceived as an emerging cause of mortality in feedlot beef cattle. This study examined the lesions and infectious agents in naturally occurring M. bovis-associated bronchopneumonia and arthritis and the relationship of this condition with bovine viral diarrhea virus (BVDV) infection. Standardized pathologic, immunohistochemical, and microbiologic investigations were conducted on 99 calves that died or were euthanized within 60 days after arrival in 72 feedlots. Cranioventral bronchopneumonia with multiple foci of caseous necrosis was identified in 54 of 99 calves, including 30 with concurrent fibrinosuppurative bronchopneumonia typical of pneumonic pasteurellosis. Mycoplasma bovis was consistently identified in these lesions by culture and immunohistochemistry, but also commonly in healthy lungs and those with pneumonia of other causes. Focal lesions of coagulation necrosis, typical of pneumonic pasteurellosis, were often infected with both Mannheimia haemolytica and M. bovis. Arthritis was present in 25 of 54 (46%) calves with M. bovis pneumonia, and all calves with arthritis had pneumonia. BVDV infection was more common in calves with lesions of bacterial pneumonia than in those dying of other causes, but BVDV infection was not more common in calves with caseonecrotic bronchopneumonia than those with fibrinosuppurative bronchopneumonia. Retrospective analysis identified cases of M. bovis pneumonia in the early 1980s that had milder lesions than the current cases. The findings suggest that, in at least some calves, M. bovis induces caseonecrotic bronchopneumonia within the lesions of pneumonic pasteurellosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Naturally OccurringMycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Gagea¹,

et al. 2006

View full text Add to dashboard Cite

show abstract

“…This peptide appears to take part in the downregulation of lymphocyte proliferation and thereby ameliorates an appropriate immune response by the host. Another mechanism of immune evasion may involve the ability of M. bovis to inhibit neutrophil oxidative burst by a mechanism that appears to involve protein kinase C signaling (29). M. bovis is also capable of surviving in the environment for an extended period of time via the production of a biofilm, although this biofilm does not appear to enhance its resistance to antibiotics but rather protects it from temperature changes and desiccation (17).…”

mentioning

confidence: 99%

Invasion of Bovine Peripheral Blood Mononuclear Cells and Erythrocytes by Mycoplasma bovis

2010

View full text Add to dashboard Cite

Mycoplasma bovis is a small, cell wall-less bacterium that contributes to a number of chronic inflammatory diseases in both dairy and feedlot cattle, including mastitis and bronchopneumonia. Numerous reports have implicated M. bovis in the activation of the immune system, while at the same time inhibiting immune cell proliferation. However, it is unknown whether the specific immune-cell population M. bovis is capable of attaching to and potentially invading. Here, we demonstrate that incubation of M. bovis Mb1 with bovine peripheral blood mononuclear cells (PBMC) resulted in a significant reduction in their proliferative responses while still remaining viable and capable of gamma interferon secretion. Furthermore, we show that M. bovis Mycoplasma bovis is a small, pleomorphic cell wall-less bacterium that is known to be a major contributing factor in the development of chronic pneumonia in feedlot cattle and mastitis in dairy cows. In addition to these two diseases, M. bovis has been linked to the development of otitis, keratoconjunctivitis, and arthritis (12). These diseases have large economic impacts, resulting in losses to both beef and dairy industries in Europe, Canada, and the United States (20). Furthermore, since M. bovis lacks a cell wall, the use of antibiotics to combat infections is limited, and the development of resistance to available antibiotics (tetracyclines and spectinomycin) has been observed (20). Interestingly, infection with M. bovis has been implicated in the potential exacerbation and enhancement of respiratory disease to other pathogens since coinfections with Histophilus somnus, bovine viral diarrhea virus, Mannheimia haemolytica, bovine respiratory syncytial virus, bovine parainfluenza virus type 3 have been observed (3,4,16,25). These findings suggest an important synergism in the development of disease during the coinfection of animals involving M. bovis and other pathogens.A number of factors appear to play an important role in the virulence and development of disease during M. bovis infection, although the specific mechanisms involved in these processes are still incompletely understood. M. bovis lacks a specialized organelle for attachment, as seen in M. pneumoniae and M. genitalium (1, 6), but instead expresses variable surface proteins (Vsps) that play a critical role in its attachment (24).These membrane surface proteins undergo substantial antigenic variation involving high-frequency phenotypic switching, resulting in an increased ability of M. bovis to evade the host's immune system (13,14,21). Furthermore, M. bovis can suppress the immune system via a secreted 26-amino-acid peptide that is 84% homologous to the C-terminal end of the VspL protein (33). This peptide appears to take part in the downregulation of lymphocyte proliferation and thereby ameliorates an appropriate immune response by the host. Another mechanism of immune evasion may involve the ability of M. bovis to inhibit neutrophil oxidative burst by a mechanism that appears to involve protein kinase C signaling...

show abstract

“…and some neutrophil functions (Thomas, et al 1991). The inhibitory effect of M. bovis on the mononuclear cells is not connected with arginine depletion or cytotoxic activity .…”

mentioning

confidence: 91%

Bovine Respiratory Syndrome (BRD) Etiopathogenesis, Diagnosis and Control

Bednarek¹,

Szymańska-Czerwińska²,

Dudek³

2012

A Bird's-Eye View of Veterinary Medicine

View full text Add to dashboard Cite

Adherence to bovine neutrophils and suppression of neutrophil chemiluminescence by Mycoplasma bovis

Cited by 58 publications

References 23 publications

Naturally OccurringMycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Naturally OccurringMycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Invasion of Bovine Peripheral Blood Mononuclear Cells and Erythrocytes by Mycoplasma bovis

Bovine Respiratory Syndrome (BRD) Etiopathogenesis, Diagnosis and Control

Contact Info

Product

Resources

About