Adherence to antiretroviral therapy and correlation with adverse effects and coinfections in people living with HIV/AIDS in the municipality of Goiás State

Oliveira, Luane da Silva; Caixeta, Lorena Maria; Martins, José Luís Rodrigues; Segati, Kelly Deyse; Moura, Rodrigo Scaliante de; Daher, Marcelo Cecílio; Pinto, Emerith Mayra Hungria

doi:10.1590/0037-8682-0467-2017

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…Achappa et al (2013) reported that side effect of treatment associated with adherence to ART (p = 0.001) 25. Oliveira et al (2018) found that adverse effects of the drugs associated with adherence to ART (p = 0.0009) 1. A study conducted by Shigdel et al (2014) showed that adverse effects of treatment associated with adherence to ART (p = 0.005) 26…”

Section: Discussionmentioning

confidence: 99%

“…The use of combination Anti Retroviral (ARV) initiated in the late 1990s. It was proven effective in suppressing viral replication and had changed the natural course of the disease, had decreased morbidity and mortality 1–6. Both Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) remained as the major public health problem in the world 3,7.…”

Section: Introductionmentioning

confidence: 99%

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<p>Factors Associated With Adherence To Anti-Retroviral Therapy Among People Living With HIV/AIDS At Wangaya Hospital In Denpasar, Bali, Indonesia: A Cross-Sectional Study</p>

Suryana¹,

Suharsono

Antara

2019

HIV

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BackgroundAcquired Immunodeficiency Syndrome (AIDS) is a major public health problem. Recently AIDS was considered as a manageable chronic disease. High adherence to Anti-Retroviral Therapy (ART) is necessary to achieve undetectable viral load, reduce morbidity, mortality and to improve the quality of life. It is also preventing the drug resistance, reducing the transmission and finally leading to live longer and healthier.ObjectivesTo assess the factor associated with ART adherence among people living with HIV/AIDS (PLWHA) at Wangaya Hospital, in Denpasar, Bali, Indonesia.MethodologyA cross-sectional study was carried out during January 2015–December 2017 among 202 PLWHA taking ART for at least 6 months. The participants were interviewed using a semi-structured questionnaire to obtain data on socio-demographic characteristics. The data were analyzed using SPSS software for windows version 24.0. Chi-square test was done, the precision value of 95% (p<0.05) was considered statistically to be significant.ResultsA total of 202 PLWHA taking ART, 170 (84.16%) were reported with high adherence (≥95%), 32 (15.84%) were low adherence (<95%). Factors found to be independently associated with high adherence to ART were employment status/occupation (p = 0.011), type of ARV (due to adverse effect of ART) (p = 0.002) and family support (p < 0.001).ConclusionThis study found that the factor associated with ART adherence among PLWHA who visited Wangaya Hospital, in Denpasar, Bali, Indonesia, was employment status, type of ARV and family support.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Factors Associated With Adherence To Anti-Retroviral Therapy Among People Living With HIV/AIDS At Wangaya Hospital In Denpasar, Bali, Indonesia: A Cross-Sectional Study</p>

Suryana¹,

Suharsono

Antara

2019

HIV

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“…The effectiveness of the regimens is most often measured by their ability to suppress the viral load and restore immunity, although this may be affected by toxicity and adverse events, which often leads to a modification of treatment [ 5 , 6 ]. The reasons for virologic failure are complex, although poor adherence to medication is the most common cause [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of four antiretroviral regimens for treating people living with HIV

et al. 2020

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The aim of this study was to compare 4 different ARV regimens in a clinical cohort in Brazil, with regard to the virologic and immunologic responses, clinical failure and reasons for changing. To compare the virologic response and clinical failure between groups we used the Cox and Kaplan Meier proportional hazard models. To analyze the immunologic outcome, we used multilevel GLLAMM and mixed effect linear regression models. To compare regimen change outcomes we used the Pearson's chi-square test. We included 840 participants distributed across the groups according to the initial ART regimen. The mean followup period was 27.8 months. Almost half the sample initiated ART with AIDS-related signs/ symptoms. Virologic response was effective in 79.6% of participants within 12 months. The tenofovir/lamivudine/efavirenz group presented a higher proportion of virologic response (VL<50 at 6 months) when compared to the zidovudine/lamivudine/efavirenz group. There was no difference between the regimens regarding the immunologic response. A total of 17.3% of individuals changed regimen because of failure and 46.5% due to adverse events. Changes due to adverse events were more frequent in the group using zidovudine/lamivudine/efavirenz. The proportion of hospitalizations at 1 year was higher in the zidovudine/ lamivudine/efavirenz group when compared to the tenofovir/lamivudine/efavirenz group. The effectiveness outcomes between the regimens were similar. Some differences may be due to the individual characteristics of patients, toxicity and acceptability of drugs. Studies are needed that compare similarly effective regimens and their respective treatment costs and financial impacts on SUS (Integrated Healthcare System).

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“…Dados do seguimento ambulatorial evidenciaram que 37% dos pacientes com HIV/AIDS apresentaram coinfecções, sendo que as mais frequentes foram sífilis (36%), seguida de hepatite B (24%) e herpes zóster (9%). A sífilis também tinha a maior incidência (40%) no ano de 2017, seguida pela tuberculose (15%), contudo, contrapondo esse dado, nossa pesquisa evidenciou apenas um caso de coinfecção por tuberculose (Oliveira et al, 2018).…”

Section: Discussionunclassified

Avaliação da adesão a terapia antirretroviral com esquemas contendo dolutegravir em um município de Goiás

Costa

Morais

Miranda

et al. 2021

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As pessoas infectadas pelo Vírus da Imunodeficiência Humana (HIV) têm acesso gratuito a Terapia Antirretroviral (TARV), no entanto para que funcione é preciso que o paciente conduza a manutenção do tratamento, pois a efetividade da TARV depende diretamente da adesão do paciente. O objetivo do presente estudo foi descrever a adesão à TARV de pacientes com HIV/AIDS atendidos pelo Sistema Único de Saúde no Estado de Goiás. Trata-se de um estudo descritivo transversal, desenvolvido na unidade de saúde Dr. Ilion Fleury Jr., referência em diagnóstico e tratamento de ISTs/AIDS na cidade de Anápolis/GO. O “Cuestionario para La evaluación de La adhesión al tratamiento antirretroviral - CEAT-VIH” foi utilizado para avaliar a adesão a TARV. Os prontuários dos pacientes foram analisados para obtenção dos resultados laboratoriais. Entre os 88 pacientes incluídos no estudo 74% (n=65) eram do sexo masculino, com média de idade de 37 anos e 49% (n=43) se declararam heterossexuais. Ao analisar a adesão foi constatado que 81% (n=72) presentaram adesão estrita, mais de 87% dos participantes possuíam carga viral não detectável, com uma contagem de linfócitos TCD4+ de ±555 células/mm³. Os resultados desse estudo permitem sugerir uma boa adesão ao novo esquema de TARV com dolutegravir, além de melhor controle de carga viral.

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Adherence to antiretroviral therapy and correlation with adverse effects and coinfections in people living with HIV/AIDS in the municipality of Goiás State

Abstract: Adherence was related to use of illicit drugs, adverse effects, and sexual orientation.

Cited by 13 publications

References 27 publications

<p>Factors Associated With Adherence To Anti-Retroviral Therapy Among People Living With HIV/AIDS At Wangaya Hospital In Denpasar, Bali, Indonesia: A Cross-Sectional Study</p>

<p>Factors Associated With Adherence To Anti-Retroviral Therapy Among People Living With HIV/AIDS At Wangaya Hospital In Denpasar, Bali, Indonesia: A Cross-Sectional Study</p>

Effectiveness of four antiretroviral regimens for treating people living with HIV

Avaliação da adesão a terapia antirretroviral com esquemas contendo dolutegravir em um município de Goiás

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