Adherence to a Topical Regimen of 5-Fluorouracil, 0.5%, Cream for the Treatment of Actinic Keratoses

Abstract

tempted to validate a tool that can be used to determine the prevalence of hyperpigmentation disorders in Chinese women. We refined the language and syntax by consulting with Chinese teachers, and then we administered the questionnaire to a focus group to maximize comprehensibility. The results of the study in 69 female Chinese subjects show that this questionnaire is valid for selfreporting of lentigines and PIH. Limitations include lack of a broad sample (most of the patients were middle-aged women) and the use of only 1 examiner. Reliability testing (test-retest) was not performed in this study by the subjects or the examiner. The focus of the study was to determine concordance between the subject and the examiner. Because of the low number of subjects with melasma, more Chinese women with melasma must be evaluated to determine the validity of this questionnaire for melasma. In addition, the melasma question specifically related melasma to pregnancy. This question may need to be refined, since many women develop melasma without any relation to pregnancy. The lentigines and PIH questions may be used in future studies to determine prevalence of these disorders in Chinese women. Determining the prevalence of pigmentary disorders and their impact on quality of life will assist in understanding the full impact of these disorders in various populations worldwide.

Non-adherence to topical treatments for actinic keratosis

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Non-adherence to topical treatments for actinic keratosis

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Daylight Photodynamic Therapy: At-Home Delivery

“…As AK is a chronic disease, requiring long-term disease management, many patients have had multiple courses of dPDT over several years and are therefore more comfortable with self-administration. An example of another treatment for the same condition is topical application of 5-Fluorouracil (5-FU) [16]. The advantage of home-based daylight PDT is that it only needs to be undertaken 1-4 times per year, versus the repeated daily use of 5-FU.…”

In vivo Confocal Laser Microscopy for monitoring of actinic keratosis treatment: a comparison with histopathologic assessment after treatment with topical 5% 5‐fluorouracil

“…In fact, 2 subjects in our study presented contact dermatitis and 7 dropped out. The long treatment and need for frequent clinical assessments justify losing seven participants …”

“…The long treatment and need for frequent clinical assessments justify losing seven participants. 59 Pharmacoeconomics studies have described 5-FU as an inexpensive, cost-effective AK treatment, with great success rates. [60][61][62] Immunosuppressed and organ transplanted patients have AKs that are refractory to treatment and progress more rapidly to invasive squamous cell carcinoma.…”

Non-adherence to topical treatments for actinic keratosis

“……”

“……”

Daylight Photodynamic Therapy: At-Home Delivery

“…As AK is a chronic disease, requiring long-term disease management, many patients have had multiple courses of dPDT over several years and are therefore more comfortable with self-administration. An example of another treatment for the same condition is topical application of 5-Fluorouracil (5-FU) [16]. The advantage of home-based daylight PDT is that it only needs to be undertaken 1-4 times per year, versus the repeated daily use of 5-FU.…”

In vivo Confocal Laser Microscopy for monitoring of actinic keratosis treatment: a comparison with histopathologic assessment after treatment with topical 5% 5‐fluorouracil

“…In fact, 2 subjects in our study presented contact dermatitis and 7 dropped out. The long treatment and need for frequent clinical assessments justify losing seven participants …”

“…The long treatment and need for frequent clinical assessments justify losing seven participants. 59 Pharmacoeconomics studies have described 5-FU as an inexpensive, cost-effective AK treatment, with great success rates. [60][61][62] Immunosuppressed and organ transplanted patients have AKs that are refractory to treatment and progress more rapidly to invasive squamous cell carcinoma.…”

Non-adherence to topical treatments for actinic keratosis

“……”

“……”

Daylight Photodynamic Therapy: At-Home Delivery

“…As AK is a chronic disease, requiring long-term disease management, many patients have had multiple courses of dPDT over several years and are therefore more comfortable with self-administration. An example of another treatment for the same condition is topical application of 5-Fluorouracil (5-FU) [16]. The advantage of home-based daylight PDT is that it only needs to be undertaken 1-4 times per year, versus the repeated daily use of 5-FU.…”

In vivo Confocal Laser Microscopy for monitoring of actinic keratosis treatment: a comparison with histopathologic assessment after treatment with topical 5% 5‐fluorouracil

“…In fact, 2 subjects in our study presented contact dermatitis and 7 dropped out. The long treatment and need for frequent clinical assessments justify losing seven participants …”

“…The long treatment and need for frequent clinical assessments justify losing seven participants. 59 Pharmacoeconomics studies have described 5-FU as an inexpensive, cost-effective AK treatment, with great success rates. [60][61][62] Immunosuppressed and organ transplanted patients have AKs that are refractory to treatment and progress more rapidly to invasive squamous cell carcinoma.…”