Topical antimicrobial acne treatment tolerability: A meaningful factor in treatment adherence?

Bartlett, Kyle; Davis, Scott; Feldman, Steven R.

doi:10.1016/j.jaad.2014.01.883

Cited by 6 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Adherence to topical therapies is worse when compared with that for oral agents: an estimated 30% to 40% of patients do not adhere to their topical treatments. 7,8 A quarter of acne prescriptions are not even filled. 9 Adherence rates can improve with simplified acne regimens, such as by utilizing 1 medication requiring once-daily application, with limited side effects, at one time.…”

Section: Annals Of Pharmacotherapy 55(10)mentioning

confidence: 99%

Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm

2021

Self Cite

View full text Add to dashboard Cite

Many patients with acne remain unsatisfied with results from the various topical treatments available and often do not improve, because of poor adherence. Even if topical clascoterone, a safe and effective treatment, were more potent than existing topicals, it could face the same poor adherence hurdle as existing treatments. Real-life efficacy will likely not reflect trial results because, for several reasons, adherence is better in trials than in real-life practice. Although topical clascoterone may be exciting initially for its promise to improve acne outcomes, the long-term place in therapy may be another topical option that minimally enhances patients’ treatment outcomes.

show abstract

Section: Annals Of Pharmacotherapy 55(10)mentioning

confidence: 99%

Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Erythromycin (ER) is a macrolide antibiotic administered topically for over 30 years in the form of gels, ointments or hydroalcoholic solutions in acne therapy. The use of ER as a base for topical dosage forms raises some technological challenges due to the physicochemical properties of this substance [1][2][3]. The main disadvantage of ER is its poor water solubility (2 mg/ ml) that limits both formulation using hydrophilic bases and skin permeability [4][5].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

Ro J Pharm Pract.

View full text Add to dashboard Cite

Erythromycin is a macrolide antibiotic prescribed for the topical treatment of acne. Pharmacologically, erythromycin has the disadvantage of being poorly soluble in water. This leads to formulation challenges in semisolid dosage forms. In recent years, many published studies have shown the ability of cyclodextrins to form complexes with drugs. These new complexes are characterized by much improved solubility and permeation compared to the "parent" molecule. The aim of this study was to synthesize an inclusion complex of erythromycin and lactide-β-cyclodextrin for the formulation of semisolid bases and the development of innovative topical preparations with erythromycin. The erythromycin-lactide-βcyclodextrin complex was characterized by scanning electron microscopy and Fourier-transform infrared spectroscopy. Semisolid formulations were pharmacologically evaluated by in vitro dissolution test and kinetic analysis of drug release by fi tt ing to representative mathematical models. The results obtained showed a prolonged release of erythromycin from erythromycin-lactide-β-cyclodextrin formulations and a higher permeability coeffi cient of these formulations compared to the erythromycin-based release.

show abstract

“…As is typical with other conditions, more severe cases are generally more resistant to topical treatment alone, although such therapies may serve as an adjunct to other vectors. Compliance is often an issue with topical acne therapies, especially those with associated unpleasant side effects such as stinging and burning, redness, or drying and flaking of skin.…”

Section: Introductionmentioning

confidence: 99%

Novel retinoid ester in combination with salicylic acid for the treatment of acne

Draelos

Lewis²,

McHugh³

et al. 2015

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Topical antimicrobial acne treatment tolerability: A meaningful factor in treatment adherence?

Cited by 6 publications

References 41 publications

Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm

Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm

Untitled

Novel retinoid ester in combination with salicylic acid for the treatment of acne

Contact Info

Product

Resources

About