Adhatoda vasica: a critical review of ethnopharmacological and toxicological data

Claeson, Ubonwan Pongprayoon; Malmfors, Törbjorn; Wikman, G.; Bruhn, Jan G.

doi:10.1016/s0378-8741(00)00225-7

Cited by 163 publications

(103 citation statements)

References 23 publications

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“…Lignans are the major components of the active extracts of the species of Justicia, exhibiting important pharmacological properties, such as antiviral, antitumoral, anti-inflamatory, and Jiménez et al, 2001;Wang et al, 2004;Woodman et al, 2005;Woodman & Malakul, 2009 Apigenin (3) Anti-inflammatory and antitumor Wahi et al, 1974;Sawatzky et al, 2006;Cai et al, 2011 Kaempferitrin (4) Antimicrobial, antiinflammatory, regulators of macrophages, and reduce the blood glucose level J. spicigera CHCl 3 Dominguez et al, 1990;Abdel-Ghani et al, 2001;Fang et al, 2005;Cazarolli et al, 2006 Vitexin (5) Anti-inflammatory and antinociceptive Wahi et al, 1974;Sridhar et al, 2006;Gorzalczany et al, 2011 Rev. Mehta et al, 1963;Ikram & Huq, 1966;Bhalla et al, 1982;Chakravarthy et al, 1982;Jindal et al, 1988;Ismail et al, 1998;Lorenz et al, 1999;Claeson et al, 2000;Shevyakov et al, 2006;Rachana et al, 2011 Vasicinone (10) Bronchodilator J. adhatoda EtOH Amin & Mehta, 1959;Mehta et al, 1963;Ikram & Huq, 1966;Bhalla et al, 1982;Chakravarthy et al, 1982;Ismail et al, 1998;Jindal et al, 1998;Lorenz et al, 1999;Rachana et al, 2011 Allantoin (11) Anti-inflammatory and anti-ulcer Fukamiya & Lee, 1986;…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

122

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Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

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Section: Resultsmentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

122

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“…Clinical studies on Aloe buettneri have proven it usefulness in curing menstrual perturbations and functional sterility in women (Bhaduri et al, 1968;Garg et al, 1970;Gupta, 1972). Many plants of the Justicia genus (J. simplex, J. adhatoda, J. insularis) are equally used to cure reproductive ailments in women (Claeson et al, 2000;Badami et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of the Aqueous Extract of <i>Justicia insularis</i> T. Anders (Acanthaceae) on Ovarian Folliculogenesis and Fertility of Female Rats

Telefo¹,

Tagne²,

Koona³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Justicia insularis T. Anders (Acanthaceae) is a medicinal plant whose leaves and those of three other plants are mixed for the preparation of a concoction used to improve fertility and to reduce labour pains in women of the Western Region of Cameroon. Previous studies have demonstrated the inducing potential on ovarian folliculogenesis and steroidogenesis of the aqueous extract of the leaf mixture (ADHJ) of four medicinal plants (Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis) among which the later represented the highest proportion. This study was aimed at evaluating the ovarian inducing potential of J. insularis in immature female rats. Various doses of the aqueous extract of J. insularis were daily and orally given, for 20 days, to immature female rats distributed into four experimental groups of twenty animals each. At the end of the experimental period some biochemical and physiological parameters of ovarian function were assayed. The administration of the aqueous extract of Justicia insularis significantly induced an early vaginal opening in all treated groups (P < 0.001) as well as an increase (at doses of 50 or 100 mg/kg) in the number of hemorrhagic points, Corpus luteum, implantation sites, ovarian weight, uterine and ovarian proteins. Ovarian cholesterol level (P < 0.05) significantly decreased in animals treated with the lowest dose (12.5 mg/kg). The evaluation of the toxicological effects of the extract on pregnancy showed that it significantly increased pre-and post-implantation losses, resorption index and decreased the rate of nidation as well as litter's weight. These results suggest that the aqueous extract of Justicia insularis induces ovarian folliculogenesis thus justifying its high proportion in the leaf mixture of ADHJ.

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“…Numerous test studies have been approved out in diverse parts of the world. It has been recommended that aqueous and ethanol extracts from plants worn in allopathic medicine are prospective sources of antiviral, antitumor, and antimicrobial agents [1]. In with a reduction of developed states of India, low-income people such as farmers, people of small isolate villages, and native communities use herbal medicines for the treatment of regular infections.…”

Section: Introductionmentioning

confidence: 99%

Identification of the Compounds of Adathoda Vasica by Gc MS Analysis and Probing the Mode of Action of the Compounds by Insilico Study

Elgal¹,

Jasmine²

2017

Asian J Pharm Clin Res

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Objective: The present study was aimed to investigate the promising compound of ethanol extracts of Adhatoda vasica against respiratory isolates by gas chromatography-mass spectrometry (GC-MS) analysis and in silico studies. Methods:The leaves of the chosen plant were extracted with ethanol, evaporated in vacuum, and stored for further study. The ethanol extract was analyzed for antibacterial activity against respiratory pathogens. To determine the dosage of the extracts against target respiratory isolates, minimal inhibitory concentration (MIC) has been determined by broth dilution method. The extract was screened to identify the promising compounds by GC-MS, and docking was performed using Schrodinger software to determine the effective of these compounds with target proteins against respiratory infections. Results:The ethanol extract of A. vasica showed promising antibacterial activity by agar diffusion method. MIC has also been determined by broth dilution method. The ethanol extract was subjected to GC-MS analysis based on the percentage of peak area, compounds were chosen for docking analysis. In silico studies had shown effective binding with target protein 2WYP (sialic acid binding protein) and 1X7Y (α-ketoacid dehydrogenase). Conclusion:The above study concludes that plant A. vasica can be used in Ayurvedic treatment and has no side effect to cure both lower and respiratory infections. Thus, we can also extend our study to drug formation.

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Adhatoda vasica: a critical review of ethnopharmacological and toxicological data

Cited by 163 publications

References 23 publications

Chemical constituents and biological activities of species of Justicia: a review

Chemical constituents and biological activities of species of Justicia: a review

Effect of the Aqueous Extract of <i>Justicia insularis</i> T. Anders (Acanthaceae) on Ovarian Folliculogenesis and Fertility of Female Rats

Identification of the Compounds of Adathoda Vasica by Gc MS Analysis and Probing the Mode of Action of the Compounds by Insilico Study

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