ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway

Li, Sha; Hong, Yang; Wan, Li; Liu, Jinyi; Ren, Liwen; Yang, Yihui; Ge, Binbin; Zhang, Yizhi; Fu, Weiqi; Zheng, Xiangjin; Du, Guanhua; Wang, Jinhua

doi:10.1038/s41401-022-00894-7

Cited by 19 publications

(9 citation statements)

References 53 publications

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“…This study for the first time revealed that ADH1C expression was reduced in Wilms’ tumor, and ADH1C overexpression suppressed the malignancy of Wilms’ tumor cells. Our results were consistent with the study on ADH1C in colorectal cancer 42 , showing that ADH1C was an antitumor gene in Wilms’ tumor.…”

Section: Discussionsupporting

confidence: 93%

“…Here, we also explored the target genes of miR-135b-3p, and found that ADH1C was the target gene of miR-135b-3p in Wilms' tumor. In cancer, ADH1C was reported to be an antitumor gene in colorectal cancer by inhibiting the growth, migration, invasion, and colony formation of colorectal cancer cells [42]. However, ADH1C could be an oncogene in lung adenocarcinoma by inducing cell proliferation and cisplatin resistance [43].…”

Section: Discussionmentioning

confidence: 99%

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LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via MiR-135b-3p/ADH1C Axis

Yu,

Liu

2023

Horm Metab Res

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Wilms’ tumor is a malignant renal cancer that arises within the pediatric urinary system. This study intended to investigate how a novel long non-coding RNA LINC01339 functions in the pathogenesis of Wilms’ tumor. An elevated miR-135b-3p expression as well as reduced levels of LINC01339 and ADH1C were observed in Wilms’ tumor. LINC01339 mediated ADH1C expression by directly binding to miR-135b-3p. The enforced LINC01339 or ADH1C markedly hindered cell growth and migration in Wilms’ tumor. The LINC01339 overexpression also repressed the growth of Wilms’ tumors in vivo, whereas miR-135b-3p overexpression exerted the opposite effects on Wilms’ tumor cells in vitro. Additionally, upregulating miR-135b-3p reversed LINC01339’s effects on the cellular processes of Wilms’ tumor cells, whereas ADH1C overexpression offset the cancer-promoting influence of miR-135b-3p upregulation on Wilms’ tumor progression. Therefore, LINC01339 prevents Wilms’ tumor progression by modulating the miR-135b-3p/ADH1C axis. Our findings substantiate that the LINC01339/miR-135 b-3p/ADH1C regulatory axis has potential to be a target for the treatment of Wilms’ tumor.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via MiR-135b-3p/ADH1C Axis

Yu,

Liu

2023

Horm Metab Res

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“…Serine is the third most metabolized substance in tumor cells after glucose and glycine 39,40 . PSAT1 is involved in the de novo synthesis of serine/glycine.…”

Section: Discussionmentioning

confidence: 99%

Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma

Wang,

Sun,

Liu

et al. 2024

Intl Journal of Cancer

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TRPS1 is aberrantly expressed in a variety of tumors, including breast, prostate, and gastric cancers, and is strongly associated with tumorigenesis or prognosis. However, the role of TRPS1 in high grade serous ovarian carcinoma (HGSC) is unknown. We investigated the relationship between TRPS1 expression and clinicopathology in HGSC patients. The tumor‐related regulatory mechanisms of TRPS1 was explored through in vivo and vitro experiments. The results showed that TRPS1 was highly expressed in HGSC compared to normal tissues. It was also linked to the cell proliferation index Ki67 and poor prognosis. In vivo experiments showed that knockdown of TRPS1 could inhibit tumor growth. In vitro experiments, knockdown of TRPS1 inhibited the proliferation of ovarian cancer cells. TRPS1 exerted its regulatory role as a transcription factor, binding to the PSAT1 promoter and promoting the expression of PSAT1 gene. Meanwhile, PSAT1 was positively correlated with CCND1 expression. These results suggest that TRPS1 affects HGSC proliferation and cell cycle by regulating PSAT1 and thus CCND1 expression.

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“…Pencheva [ 52 ] et al also reported that APOE inhibits invasion and angiogenesis in melanoma by attracting tumor cell LRP1 receptors and endothelial cell LRP8 receptors, respectively. Alcohol dehydrogenase 1C (ADH1C) is a member of the alcohol dehydrogenase family that metabolizes ethanol, fatty alcohols, and lipid peroxidation products [ 53 ]. ADH1C is associated with a poor prognosis for liver cancer and lung adenocarcinoma [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer

Liu,

Ren,

Fang

et al. 2024

J Transl Med

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Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis is the predominant metastatic mode developed in most pancreatic cancer cases, which seriously affects the overall survival rate of patients. Abnormally activated endoplasmic reticulum stress and lipid metabolism reprogramming are closely related to tumor growth and metastasis. This study aims to construct a prognostic model based on endoplasmic reticulum stress and lipid metabolism for pancreatic cancer, and further explore its correlation with tumor immunity and the possibility of immunotherapy. Methods Transcriptomic and clinical data are acquired from TCGA, ICGC, and GEO databases. Potential prognostic genes were screened by consistent clustering and WGCNA methods, and the whole cohort was randomly divided into training and testing groups. The prognostic model was constructed by machine learning method in the training cohort and verified in the test, TCGA and ICGC cohorts. The clinical application of this model and its relationship with tumor immunity were analyzed, and the relationship between endoplasmic reticulum stress and intercellular communication was further explored. Results A total of 92 characteristic genes related to endoplasmic reticulum stress, lipid metabolism and liver metastasis were identified in pancreatic cancer. We established and validated a prognostic model for pancreatic cancer with 7 signatures, including ADH1C, APOE, RAP1GAP, NPC1L1, P4HB, SOD2, and TNFSF10. This model is considered to be an independent prognosticator and is a more accurate predictor of overall survival than age, gender, and stage. TIDE score was increased in high-risk group, while the infiltration levels of CD8+ T cells and M1 macrophages were decreased. The number and intensity of intercellular communication were increased in the high ER stress group. Conclusions We constructed and validated a novel prognostic model for pancreatic cancer, which can also be used as an instrumental variable to predict the prognosis and immune microenvironment. In addition, this study revealed the effect of ER stress on cell–cell communication in the tumor microenvironment.

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ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway

Cited by 19 publications

References 53 publications

LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via MiR-135b-3p/ADH1C Axis

LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via MiR-135b-3p/ADH1C Axis

Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma

Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer

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