Adenovirus receptors on antigen‐presenting cells of the skin

Abstract

Skin, the largest human organ, is part of the first line of physical and immunological defense against many pathogens. Understanding how skin antigen-presenting cells (APCs) respond to viruses or virus-based vaccines is crucial to develop antiviral pharmaceutics, and efficient and safe vaccines.Here, we discuss the way resident and recruited skin APCs engage adenoviruses and the impact on innate immune responses.

Special issue for biology of the cell “intracellular trafficking of viruses”

“…Focusing on skin cells, they outline the role of various adenovirus receptors for efficient infection of immune cells. They also highlight the importance of post‐translational modifications of cell surface proteins in virus uptake (Gerber‐Tichet Dienst & Kremer, 2022). Because virus‐receptor interactions and subsequent viral fusion with host membrane cells are highly dynamic processes, advanced imaging tools are needed to shed light on virus entry.…”