Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy

Gujar, Shashi; Pol, Jonathan G.; Kumar, Vishnupriyan; Lizarralde-Guerrero, Manuela; Konda, Prathyusha; Kroemer, Guido; Bell, John C.

doi:10.1038/s41596-024-00985-1

Cited by 1 publication

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“…One promising direction is the enhancement of oncolytic virus' specificity and efficacy through advanced genetic engineering techniques [ 76 , 77 ]. This can potentially improve the targeting of cancer cells while minimizing damage to normal cells.…”

Section: Current Status Of Oncolytic Virotherapy In Clinical Settingsmentioning

confidence: 99%

Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments

Yan,

Zhang,

Chen

et al. 2024

Cancer Cell Int

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As one of the significant challenges to human health, cancer has long been a focal point in medical treatment. With ongoing advancements in the field of medicine, numerous methodologies for cancer therapy have emerged, among which oncolytic virus therapy has gained considerable attention. However, oncolytic viruses still exhibit limitations. Combining them with various therapies can further enhance the efficacy of cancer treatment, offering renewed hope for patients. In recent research, scientists have recognized the promising prospect of amalgamating oncolytic virus therapy with diverse treatments, potentially surmounting the restrictions of singular approaches. The central concept of this combined therapy revolves around leveraging oncolytic virus to incite localized tumor inflammation, augmenting the immune response for immunotherapeutic efficacy. Through this approach, the patient's immune system can better recognize and eliminate cancer cells, simultaneously reducing tumor evasion mechanisms against the immune system. This review delves deeply into the latest research progress concerning the integration of oncolytic virus with diverse treatments and its role in various types of cancer therapy. We aim to analyze the mechanisms, advantages, potential challenges, and future research directions of this combination therapy. By extensively exploring this field, we aim to instill renewed hope in the fight against cancer.

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Section: Current Status Of Oncolytic Virotherapy In Clinical Settingsmentioning

confidence: 99%

Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments

Yan,

Zhang,

Chen

et al. 2024

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy

Cited by 1 publication

References 513 publications

Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments

Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments

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