Adenovirus Parotitis in Patients with AIDS

Gelfand, Mikhail S.; Cleveland, Kerry O.; Lancaster, Danny J.; Corbett, Cathy E.; Florendo, Noel T.

doi:10.1093/clinids/19.6.1045

Cited by 28 publications

(12 citation statements)

References 10 publications

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“…Coexisting infections are very seldom reported in the parotid 509 J Oral Pathol Med 30: 507-9 gland of AIDS patients. We found a single report of coinfection of the parotid gland with adenovirus and Mycobacterium aviumintracellulare (6). The patient had advanced HIV infection, low CD4 cell count and had had previous opportunistic infections, similar to the present case.…”

supporting

confidence: 83%

Simultaneous occurrence of lymphoepithelial cysts, cytomegalovirus and mycobacterial infections in the intraparotid lymph nodes of a patient with AIDS

Vargas¹,

Villalba²,

Passos³

et al. 2001

J Oral Pathology Medicine

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We report the unusual simultaneous occurrence of lymphoepithelial cysts, cytomegalovirus (CMV) and mycobacterial infections in the intraparotid lymph nodes of a 52-year-old AIDS patient who died of disseminated mycobacteriosis. Although cytomegalovirosis is a common finding in the salivary glands of HIV patients, the association of CMV inclusions with lymphoepithelial cyst (LC) has not been previously reported. Parotid mycobacterial infection is an uncommon finding, despite its usual disseminated presentation in HIV patients. These data emphasize that in immunosuppressed patients, simultaneous diseases of the parotid gland may occur and should be considered for diagnosis and treatment.

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supporting

confidence: 83%

Simultaneous occurrence of lymphoepithelial cysts, cytomegalovirus and mycobacterial infections in the intraparotid lymph nodes of a patient with AIDS

Vargas¹,

Villalba²,

Passos³

et al. 2001

J Oral Pathology Medicine

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“…Coexisting infections are very seldom reported in the parotid gland of AIDS patients. Currently, there are two reported that showed this association, one of them belonging to our cohort (Vargas et al , 2001) and the other to Gelfand et al (1994). Such manifestations in the parotid gland are probably the result of profound immunosuppression.…”

Section: Discussionmentioning

confidence: 52%

Parotid gland involvement in advanced AIDS

et al. 2003

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“…asymptomatic) in his right parotid gland and the AdhAQP1 vector transduced some of the cells containing WT Ad5. Adenoviruses can infect parotid glands, although frank clinical manifestations (parotitis) are only reported for immunocompromised patients 11. The presence of an asymptomatic Ad5 infection in this patient might then permit either: (i) a recombination event to occur between the WT Ad5 and AdhAQP1 or (ii) reactivation of the WT Ad5 and subsequent replication of both the WT Ad5 and the AdhAQP1 vector, independently, in the absence of a recombination event.…”

Section: Resultsmentioning

confidence: 95%

“…First, adenoviral infections are quite common across widely diverse populations 12–15, with latent infections present in many organs and in lymphoid tissue 16. Second, the reactivation of latent adenovirus can occur in immunosuppressed patients, such as in post‐transplant or HIV‐AIDS patients 11, 16, 17. Furthermore, in transplant patients, this reactivation appears to be facilitated during antiviral (CMV) prophylaxis with either ganciclovir or valganciclovir 16.…”

Section: Discussionmentioning

confidence: 99%

Transient detection of E1‐containing adenovirus in saliva after the delivery of a first‐generation adenoviral vector to human parotid gland

Zheng

Nikolov

Alevizos

et al. 2009

The Journal of Gene Medicine

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Background Radiation-induced salivary hypofunction is a common side-effect of treatment for head and neck cancers. Patients suffer significant morbidity and there is no suitable conventional therapy. We are conducting a Phase I clinical trial, using a first-generation serotype 5 adenoviral (Ad5) vector encoding human aquaporin-1 (AdhAQP1) to treat such patients. One week after the administration of AdhAQP1 to an enrolled, generally healthy patient, E1-containing adenovirus was detected in parotid saliva. Methods The real-time quantitative polymerase chain reactuion (PCR) was used to measure the Ad5 E1 gene and AdhAQP1 in saliva and serum. PCR and sequencing were used to characterize viral/vector DNA extracted from saliva. The presence of infectious adenovirus was assessed by the inoculation of A549 cells with aliquots of saliva. Serum Ad5 neutralizing antibodies were measured by the inhibition of 293-cell transduction with an Ad5 vector encoding luciferase. Multiple clinical evaluations were performed. Results On day 7 after AdhAQP1 delivery, low levels of the Ad5 E1 gene were detected in parotid saliva (82 copies/μl). In addition, significant levels of AdhAQP1 were also detected (1.5 × 103 copies/μl). The patient was asymptomatic and subsequent analysis of parotid saliva samples prior to day 7 and after day 7 until day 42 was negative for both virus and vector. No virus or vector was detected in serum at any time. Detailed PCR analyses of DNA extracted from the day 7 parotid saliva sample suggested the absence of a recombination event, and no infectious virus was found. Conclusions The patient most likely had a latent Ad5 infection in the targeted parotid gland that was activated after gene transfer and was without clinical consequence. Published in 2009 by John Wiley & Sons, Ltd.

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Adenovirus Parotitis in Patients with AIDS

Cited by 28 publications

References 10 publications

Simultaneous occurrence of lymphoepithelial cysts, cytomegalovirus and mycobacterial infections in the intraparotid lymph nodes of a patient with AIDS

Simultaneous occurrence of lymphoepithelial cysts, cytomegalovirus and mycobacterial infections in the intraparotid lymph nodes of a patient with AIDS

Parotid gland involvement in advanced AIDS

Transient detection of E1‐containing adenovirus in saliva after the delivery of a first‐generation adenoviral vector to human parotid gland

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