Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice

Hashiba, Takafumi; Suzuki, Motoyoshi; Nagashima, Yoji; Suzuki, Shunsuke; Inoue, Satoshi; Tsuburai, Takahiro; Matsuse, Takeshi; Ishigatubo, Y

doi:10.1038/sj.gt.3301540

Cited by 135 publications

(104 citation statements)

References 59 publications

(70 reference statements)

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“…Interestingly, the upregulation of stress proteins such as HO-1 and Hsp70 has been shown to limit inflammatory responses in many models [148][149][150]. Moreover, CO treatment in vivo has been shown to induce HO-1 in the liver [129] and Hsp70 in the lung [130].…”

Section: Co Signalingmentioning

confidence: 99%

CO metabolism, sensing, and signaling

et al. 2011

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Abstract.CO is a colorless and odorless gas produced by the incomplete combustion of hydrocarbons, both of natural and anthropogenic origin. Several microorganisms, including aerobic and anaerobic bacteria and anaerobic archaea, use exogenous CO as a source of carbon and energy for growth. On the other hand, eukaryotic organisms use endogenous CO, produced during heme degradation, as a neurotransmitter and as a signal molecule. CO sensors act as signal transducers by coupling a ''regulatory'' heme-binding domain to a ''functional'' signal transmitter. Although high CO concentrations inhibit generally heme-protein actions, low CO levels can influence several signaling pathways, including those regulated by soluble guanylate cyclase and/or mitogenactivated protein kinases. This review summarizes recent insights into CO metabolism, sensing, and signaling.

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Section: Co Signalingmentioning

confidence: 99%

CO metabolism, sensing, and signaling

et al. 2011

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“…These cytoprotective functions can be applied for therapeutic purposes. We previously reported that chemical induction of HO-1 suppresses lupus nephritis (15) and that adenovirus vector-mediated gene transfer of HO-1 complementary DNA (cDNA) has beneficial effects on lipopolysaccharide (LPS)-induced lung injury (16), influenza viral pneumonia (17), bleomycin-induced pulmonary fibrosis (18), Pseudomonas chronic respiratory infection (19), and elastase-induced emphysema (20) in mouse models. Similarly, favorable outcomes have been achieved with therapies using HO-1 chemical inducers or with gene transfer in other animal models, including ischemia/ reperfusion-induced injuries of the heart (9) and liver (21), LPS-induced ocular inflammation (22), and allogenic heart allotransplantation (23).…”

mentioning

confidence: 99%

Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis

Kobayashi

Takeno

Saito

et al. 2006

Arthritis & Rheumatism

112

103

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Objective. To examine the expression and pathogenetic roles of heme oxygenase 1 (HO-1), an inducible heme-degrading enzyme with antiinflammatory properties, in rheumatoid arthritis (RA).Methods. HO-1 expression in synovial tissue from patients with RA, patients with osteoarthritis, and patients with noninflammatory joint diseases was determined by immunoblotting and immunohistochemistry. Conclusion. Our data demonstrate that HO-1 is expressed in RA synovial tissues and plays a regulatory role in the development of inflammation. The pharmacologic effects of auranofin depend, in part, on the levels of HO-1, suggesting that HO-1 induction is a novel therapeutic strategy for RA.

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“…10 Of particular interest is a study demonstrating that adenovirus-mediated transfer of heme oxygenase-1 (HO-1) cDNA reduces the lung damage and influx of leukocytes in influenzainfected mice, while markedly boosting survival (60% vs. 0% in controls). 33 HO-1 generates bilirubin, which recently has been shown to be a potent physiological inhibitor of NADPH oxidase activity. [34][35][36][37] The possibility that concurrent generation of carbon monoxide also contributed to the observed protection merits consideration, but it is reasonable to suspect that the potent antioxidant activity of bilirubin contributed prominently to the protection afforded by HO-1 transfection.…”

Section: Nadph Oxidase As a Potential Targetmentioning

confidence: 99%