Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics

McCarty, Mark F.; Barroso-Aranda, Jorge; Contreras, Francisco

doi:10.1016/j.mehy.2009.04.052

Cited by 17 publications

(21 citation statements)

References 37 publications

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“…The findings of this study may reflect the fact that the symptoms of influenza are often attributable to an overexuberant immune response evoked by infection, rather than from the direct cytopathic impact of the virus on lung epithelium (McCarty et al 2010). With respect to the impact of NAC on cell-mediated immunity-the efficiency of which typically declines with aging-there is evidence that glutathione is crucially important to efficient function of dendritic cells, the central coordinators of cell-mediated immunity (Kim et al 2007).…”

Section: Supplemental Nac In Aging Humans and Rodents Provides Versatmentioning

confidence: 81%

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

McCarty

DiNicolantonio

2015

AGE

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Restricted dietary intakes of protein or essential amino acids tend to slow aging and boost lifespan in rodents, presumably because they downregulate IGF-I/ Akt/mTORC1 signaling that acts as a pacesetter for aging and promotes cancer induction. A recent analysis of the National Health and Nutrition Examination Survey (NHANES) III cohort has revealed that relatively low protein intakes in mid-life (under 10 % of calories) are indeed associated with decreased subsequent risk for mortality. However, in those over 65 at baseline, such low protein intakes were associated with increased risk for mortality. This finding accords well with other epidemiology correlating relatively high protein intakes with lower risk for loss of lean mass and bone density in the elderly.

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Section: Supplemental Nac In Aging Humans and Rodents Provides Versatmentioning

confidence: 81%

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

McCarty

DiNicolantonio

2015

AGE

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“…Further evidence of involvement of nitrosative stress in influenza A is the demonstration of strong 8-nitroguanosine immunostaining in the cytosol of bronchial and bronchiolar epithelial cells of influenza virus-infected wild-type mice but not iNOS-deficient mice [15]. Moreover, a number of studies have demonstrated that reactive oxygen species contribute to the exacerbation of lung inflammation and lethality in influenza-infected mice, while the use of glutathione precursor promotes survival in influenza-infected mice [16,17]. The results reported in this work are in agreement with those of a study by Li et al, who demonstrated a 2.4-fold increase in nitric oxide production in patients infected with influenza A [8], and also showed that the production of nitric oxide in pdmH1N1 was significantly less than that of seasonal influenza A.…”

Section: Discussionmentioning

confidence: 99%

“…Influenza A is a single-stranded negative sense RNA virus of the genus orthomyxiviridae that encodes eight major genes, including two major surface hemagglutinin (16) and nuraminidase (9) subtypes. From 19 April to 12 September 2009, the majority (60.6%) of all influenza specimens reported to World Health Organization (WHO) were pdmH1N1 or S-OIV, viruses [1].…”

Section: Introductionmentioning

confidence: 99%

Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq

Al-Nimer

Mahmood

Khazaal

2011

J Infect Dev Ctries

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Introduction: Influenza A virus infection is associated with oxidative and nitrosative stress. This study aimed to assess nitrosative stress in pandemic H1N1 (pdmH1N1) and seasonal influenza A infected patients. Methodology: The study included the following subjects: 20 patients infected with seasonal (negative one-step probe RT-PCR) influenza and 12 patients infected with pdmH1N1 (positive, one-step probe RT-PCR) influenza during the 2009 pandemic in Iraq. Twenty healthy subjects served as controls. Serum nitric oxide using Greiss reagent and peroxynitrite were used to assess nitrosative stress status. Results: Serum nitric oxide and peroxynitrite are significantly increased in patients infected with seasonal and pdmH1N1 influenza compared with the levels in healthy subjects. Infected patients with seasonal influenza showed significantly higher numbers of serum nitrogen species than corresponding pdmH1N1 infected patients. The turnover process reflected by the peroxynitrite/nitric oxide ratio was 0.177, 0.313 and 0.214 in healthy subjects, seasonal and pdmH1N1infected patients respectively. Conclusions: Influenza A virus infection is associated with significant nitrosative stress activity which is more pronounced in seasonal than in pdmH1N1 infected patients. The determination of serum nitric oxide and peroxynitrite may serve as biochemical markers.

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“…A series of studies addressed the question of the effects of NAC on the outcome of influenza pneumonia (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). NAC was shown to have direct anti-viral effects, to decrease the levels of pro-inflammatory cytokines and to be anti-apoptotic (11,(13)(14)(15)(16)(17)(19)(20)(21)(22).…”

Section: Key Pointsmentioning

confidence: 99%

“…NAC was shown to have direct anti-viral effects, to decrease the levels of pro-inflammatory cytokines and to be anti-apoptotic (11,(13)(14)(15)(16)(17)(19)(20)(21)(22). Inhibition of mucin production and effects on B-and T-cell immune responses have also been reported (10,11,19).…”

Section: Key Pointsmentioning

confidence: 99%

N-acetylcysteine: an old drug with variable Anti-influenza properties

Casanova

Garigliany

2016

jcbmr

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N-acetylcysteine (NAC) is a mucolytic drug commonly used as an adjuvant therapy in patients with respiratory conditions associated with excessive mucus production. NAC also has anti-oxidant activities that proved useful in the management of oxidative stress. These anti-oxidant capacities of NAC are mostly indirect, via a pro-glutathione effect where NAC provides L-cysteine residues required for glutathione synthesis. This activity is thought to be the basis for the protective effect of NAC administration in influenza patients and in mouse models of the disease. NAC was shown to limit lung inflammation, damage associated with the virus, and viral growth, at least in vitro. However, the anti-viral activity was highly variable depending on the influenza A strain. The reasons for these inter-strain variations are still unknown, but might be related to the level of nuclear factor-κB activation required for the virus to achieve its infectious cycle.

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Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics

Cited by 17 publications

References 37 publications

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq

N-acetylcysteine: an old drug with variable Anti-influenza properties

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