Adenovirus Infections in Hospitalized Patients in Israel: Epidemiology and Molecular Characterization

Mandelboim, Michal; Dror, Pnina; Azar, Roberto; Bromberg, Michal; Mendelson, Ella

doi:10.1128/jcm.00979-10

Cited by 33 publications

(39 citation statements)

References 28 publications

(30 reference statements)

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“…On the other hand, prevalence of HAdV infection in this study was lower than reported from non-Asian countries such as Brazil 7.1% [13], Peru 6.2% [14], Canada 7.73% [15], Columbia 5% [16]. In addition, Michal Mandelboim and colleagues found an infection prevalence of 18.3% in Israel; however, this study included immune deficient patients [17]. The male/female ratio (M/F) of HAdV infected NP samples in our study was 1.16:1,which is lower than previously reported from Israel 1.48:1 [17], Taiwan 1.3:1 [21], and Peru 1.3:1 [14].…”

Section: Discussionmentioning

confidence: 61%

Molecular characterization of human adenovirus infection in Thailand, 2009–2012

Sriwanna

Chieochansin

Vuthitanachot³

et al. 2013

Virol J

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BackgroundHuman adenovirus (HAdV) can cause a wide spectrum of human diseases worldwide.MethodsUsing PCR and sequence analysis, we investigated HAdV infection prevalence in the Thai population for four years from January 2009 to December 2012. We collected Nasopharyngeal swab/aspirate (NP) specimens from patients in Bangkok, Khon Kaen, and Nakhon Si Thammarat province and fecal specimens only from Bangkok and Khon Kaen province.ResultsWe observed HAdV infection in 1.04% (82/7,921) of NP samples and in 5.84% (76/1,301) of fecal specimens. HAdV-B3 (32%) and HAdV-C1 (31%) were the genotypes most commonly associated with NP specimens followed by HAdV-C2 (13%) and HAdV-C5 (12%). In fecal specimens, we found that 25% harbored HAdV-F41 followed by HAdV-C1 (18%), HAdV-C2 (16%), and HAdV-B3 (13%). Out of all population subsets, children below the age of 3 years were the most likely to be HAdV positive (63.29%). In addition, HAdV infection occurred throughout the year without a seasonal distribution pattern, although HAdV infection of NP samples peaked from January-April while HAdV infection peaked from January to March and then again from May to July in fecal samples.ConclusionsThis study has for the first time reported the HAdV infection rate in Thai NP and fecal specimens from 2009–2012. We observed that HAdV-B3 and HAdV-C1 were commonly found in NP specimens, and that HAdV-F41 was the most prevalence in fecal specimens in Thailand during the study period.

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Section: Discussionmentioning

confidence: 61%

Molecular characterization of human adenovirus infection in Thailand, 2009–2012

Sriwanna

Chieochansin

Vuthitanachot³

et al. 2013

Virol J

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“…It has been shown earlier that some HAdV types correlated specifically to one or two months throughout the year, or were also found in some years but not in others [43]. Similar genetic epidemiological studies have shown that HAdV types, comprising HAdV-C1, -C2, -B3, -C5, -C6, and -B7 were mainly involved in respiratory tract infections in children living in Argentina, Iceland, Chile, Taiwan, Canada, China, Malaysia, Korea, Israel, Egypt and the USA, respectively [17], [22], [25], [31], [51], [52], [58], [59], [60], [61], [62]. HAdV types -C1, -C2 and -B3 were detected in most of these studies.…”

Section: Discussionmentioning

confidence: 79%

A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine

et al. 2012

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A molecular epidemiology survey was performed in order to establish and document the respiratory adenovirus pathogen profiles among children in Southern Palestine. Three hundred and thirty-eight hospitalized pediatric cases with adenovirus-associated respiratory tract infections were analyzed. Forty four cases out of the 338 were evaluated in more detail for the adenoviruses types present. All of the children resided in Southern Palestine, that is, in city, village and refugee camp environments within the districts of Hebron and Bethlehem. Human adenoviruses circulated throughout 2005–2010, with major outbreaks occurring in the spring months. A larger percent of the children diagnosed with adenoviral infections were male infants. DNA sequence analysis of the hexon genes from 44 samples revealed that several distinct adenovirus types circulated in the region; these were HAdV-C1, HAdV-C2, HAdV-B3 and HAdV-C5. However, not all of these types were detected within each year. This is the first study ever conducted in Palestine of the genetic epidemiology of respiratory adenovirus infections.

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“…Adenovirus types 1, 2, 3, 5, 6, and 7 primarily cause respiratory diseases (26). Among these adenovirus types, HAdV-1, 2, 3, and 7 are the major types associated with acute respiratory illness (27).…”

Section: Discussionmentioning

confidence: 99%

Detection and Molecular Typing of Human Adenoviruses Associated with Respiratory Illnesses in Kerala

2016

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SUMMARY: Adenoviruses are responsible for approximately 5-10z of acute respiratory infections globally. However, there are a limited number of reports on the types of circulating respiratory human adenoviruses (HAdV) in India. We detected HAdV in the post-mortem specimens of a young child who died as a result of an acute febrile illness. To retrospectively investigate the circulating adenovirus types in the Alappuzha region, samples (n ＝ 235) collected from patients with influenza-like illnesses who participated in the influenza surveillance program were screened for HAdV. Fourteen samples were identified as positive for adenovirus by PCR analysis. Adenovirus was isolated from 3 of the 14 PCRpositive samples cultured using HEK-293 cell lines. The viral strains isolated in the study were from children between 6 and 10 years of age. The isolates were identified as adenovirus species C and E. Sequencing analysis of the fiber gene and a BLAST search revealed that 2 of the isolates were type HAdV-C2, and the third isolate was a HAdV-E4. A fiber gene sequence-based phylogenetic tree showed that the HAdV-E4 isolate was similar to the Japanese HAdV-E4 strain, whereas the HAdV-C2 isolates formed a distinct cluster. Respiratory infections due to HAdV-E4 are generally observed in adults; this study is the first to demonstrate the involvement of the HAdV-E4 strain in respiratory illnesses in children.

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Adenovirus Infections in Hospitalized Patients in Israel: Epidemiology and Molecular Characterization

Cited by 33 publications

References 28 publications

Molecular characterization of human adenovirus infection in Thailand, 2009–2012

Molecular characterization of human adenovirus infection in Thailand, 2009–2012

A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine

Detection and Molecular Typing of Human Adenoviruses Associated with Respiratory Illnesses in Kerala

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