Adenosquamous carcinoma of the pancreas, a rare tumor entity: a case report

Abstract

IntroductionAdenosquamous carcinoma of the pancreas is a rare variant of exocrine pancreatic tumor. This type of tumor is extremely rare as only few similar cases have been described in the literature.Case presentationWe present a case of a 72 years old male patient who was admitted to the hospital complaining of epigastric pain and jaundice. Pancreatic carcinoma of the head was diagnosed and a pylorus preserving pancreaticoduodenectomy was performed.ConclusionThis type of cancer is a very aggressive tumor followed by a dismisal prognosis. Multimodality therapy seems to be a reasonable approach but more studies are needed, to propose the most effective treatment.

Comparative outcomes of adenosquamous carcinoma of the pancreas: An analysis of the National Cancer Database

“…4 The proportion of squamous cell differentiation, either <30% or ≥30%, does not appear to predict overall survival. 5 The relative rarity of ASCP has limited the characterization of clinicopathological variables associated with outcome to case studies, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] single institution studies with a paucity of patients 3,5,[24][25][26][27][28][29] or examination of administrative datasets with limited co-variate availability. 30,31 Most series report a poor prognosis for patients with ASCP with median overall survival ranging from 4 to 19 months depending on surgical resection and/or the receipt of adjuvant chemotherapy.…”

415 Patients With Adenosquamous Carcinoma Of The Pancreas: A Population-Based Analysis Of Prognosis and Survival

“…In our literature search, we identified a total of 307 reported patients with adenosquamous carcinoma of the pancreas. A number of studies examined fewer than 5 patients each with adenosquamous carcinoma [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] . Table 1 (including studies with five or more patients) summarizes the number of patients, tumor location, resection status, and survival reported in previous studies.…”

Pancreatic adenosquamous carcinoma with 7‐year survival: A case report and literature review

“…Fortunately, the current patient's abdominal pain due to obstructive pancreatitis led to early detection with a small tumor size (1.9 cm). According to the published literature, the size of the lesion is also a significant prognostic factor of pancreatic adenosquamous carcinoma (4.4 ± 1.7 cm for no less than one‐year survival vs 6.7 ± 3.5 cm for less than one‐year survival, P = 0.04 by the Mann–Whitney test).…”

“…As the effects of chemotherapy and radiation differ by the histological type of tumor, the proportion of the squamous cell component is possibly as a key prognostic factor. Case reports with long survival time and recent studies performed on a relatively large sample size commonly describe the need for CRT in the treatment of this tumor. In our patient, IORT followed by long‐term adjuvant chemotherapy may be associated with outstanding prognosis.…”