Comparative outcomes of adenosquamous carcinoma of the pancreas: An analysis of the National Cancer Database

Hester, Caitlin A.; Augustine, Mathew M.; Choti, Michael A.; Mansour, John C.; Minter, Rebecca M.; Polanco, Patricio M.; Porembka, Matthew R.; Wang, Sam C.; Yopp, Adam C.

doi:10.1002/jso.25112

Cited by 44 publications

(55 citation statements)

References 35 publications

(68 reference statements)

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“…These relatively rare tumors are larger and more commonly found in the body or tail of the pancreas. An analysis of the National Cancer Database revealed that adenosquamous carcinoma of the pancreas is associated with worse outcome in stage I/II resected patients when compared to pancreatic adenocarcinoma …”

Section: Discussionmentioning

confidence: 99%

Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature

et al. 2019

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Metastatic carcinoma to the skin occurs in only a minority of patients with a visceral or internal malignancy, with breast, lung, and colorectum accounting for the majority of cases. We present the case of a 66-year-old man with a recent violaceous nodule of the left scalp (1.2 × 1.0 × 0.2 cm) that was a metastatic pancreatic adenosquamous carcinoma, representing a seemingly rare event. Two months prior, after complaining of right hip pain, an image revealed a right femoral lesion. A biopsy of that lesion showed moderately differentiated adenocarcinoma. Subsequent imaging showed a mass in the pancreatic tail and also markedly elevated serum tumor markers, CA 19-9 and carcinoembryonic antigen (5325 and 111.5 U/mL, respectively). Before the appearance of the scalp nodule, the patient received radiotherapy and was started on chemotherapy, which was continued after diagnosis and resection of the nodule. Subsequent metastases developed in the liver, lung and additional cutaneous lesions. He died 11 months after initial presentation with right hip pain. As this case shows, cutaneous metastases confer a poor prognosis, often with less than a year survival following their appearance.

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Section: Discussionmentioning

confidence: 99%

Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature

et al. 2019

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“…Pancreatic cancer is a very aggressive malignancy with a very poor prognosis a 5-year survival rate of only 1-9.2%, and more than half of patients already have distant metastases at diagnosis (1)(2)(3)(4). Among the pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is the most common, accounting for about 85%, and pancreatic adenosquamous cell carcinoma (PASC) is a rare type, accounting for only 1-4% (1,2,5). It is clearly known that the prognosis of PASC is much worse than PDAC, and even in resected patients the median survival is only 5-14.8 months (1,2,(5)(6)(7)(8)(9)(10)(11).…”

Section: Examine the Clinicopathological Features Of Pancreatic Adenomentioning

confidence: 99%

Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases

et al. 2019

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“…Data on primary pancreatic SCC and A‐SCC are sparse, as they represent only 0.5%‐2%, and 5%, of pancreatic neoplasms, respectively . Incidence rates for primary pancreatic SCC and A‐SCC are increasing .…”

Section: Introductionmentioning

confidence: 99%

“…6 Data on primary pancreatic SCC and A-SCC are sparse, as they represent only 0.5%-2%, and 5%, of pancreatic neoplasms, respectively. 7,8 Incidence rates for primary pancreatic SCC and A-SCC are increasing. 9 The prognosis for primary pancreatic SCC is thought to be poor compared with AC; however, this is based primarily on case reports and small case series.…”

Section: Introductionmentioning

confidence: 99%

The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer

et al. 2020

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Background The prognosis for nonmetastatic, primary pancreatic squamous cell carcinoma (SCC) is thought to be poor compared with adenocarcinoma (AC); however, this is based on limited data. Additionally, the optimal definitive treatment strategy for nonmetastatic pancreatic SCC is unknown. Methods We analyzed patients with nonmetastatic pancreatic cancer using the National Cancer Database for patients diagnosed from 2006 to 2014. Patients were analyzed according to histology—only AC, adenosquamous carcinoma (A‐SCC), and SCC were included. The primary endpoint was overall survival (OS) from the time of diagnosis. Results A total of 94 928 cases were included; 94 016 AC, 757 A‐SCC, and 155 SCC. Median OS was lower for SCC (8.67 months), compared to AC (13.93 months) and A‐SCC (12.71 months, P < .001). SCC was resected less often (25.5% vs 46.7% and 74.5%). On subgroup analysis of patients with pancreatic SCC, factors on multivariate analysis associated with improved survival included surgery (HR 0.19, P < .001), and chemotherapy (HR 0.22, P = .01). In 38 patients with SCC undergoing surgical resection, median OS improved (MS = 6.8 months without surgery vs 21.3 months with surgery, P < .001). Conclusions Nonmetastatic pancreatic SCC presents with more advanced disease, which is less often surgically resected or treated with any definitive local therapy. In contrast, AC and A‐SCC behave more similarly and have higher surgical resection rates and improved survival. In patients with nonmetastatic SCC of the pancreas, surgical resection provides the most significant survival benefit, with systemic chemotherapy providing a less significant benefit, and localized radiation providing no statistical benefit for any subgroup.

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Comparative outcomes of adenosquamous carcinoma of the pancreas: An analysis of the National Cancer Database

Abstract: Although patients with ASCP and PDAC tumors have similar survival when non-surgical and surgical patients are combined, ASCP is associated with worse survival in stage I/II resected patients.

Cited by 44 publications

References 35 publications

Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature

Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature

Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases

The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer

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