Adenosquamous carcinoma arising in Barrett's esophagus

Noguchi, Tsuyoshi; Uchida, Yuzo; Fumoto, Shintaro; Wada, Shinsuke; Sato, Tetsuro; Takeno, Shinsuke

doi:10.1007/bf02913171

Cited by 25 publications

(18 citation statements)

References 9 publications

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“…ASC tumors are most commonly found in the lower third of the esophagus [18] , and an association between ASC and Barrett's esophagus has been suggested [24][25][26] . In rats, esophagitis caused by reflux of duodenal contents has been shown to induce glandular metaplasia and ultimately ASC [24] .…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

et al. 2017

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Objectives: Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. Its behavior is aggressive but poorly understood. Using the National Cancer Database (NCDB), the clinical features and overall survival of ASC were compared with AC and SCC. Methods: The NCDB was queried for patients with esophageal ASC, AC, and SCC. Univariate association of histology with patient characteristics and overall survival were analyzed and socioeconomic characteristics were balanced. Results: Clinical M stage was 0 in a significantly lower proportion of ASC (69.0%) than in AC (70.9%) or SCC (75.6%) (p < 0.001). Median survival was lower in patients with ASC (9.6 months) than with AC (13.5) or SCC (9.7) and 2-year OS was lower in patients with ASC (23.8%) than with AC (34.6%) or SCC (26.5%) (p < 0.001). The OS hazard ratio for ASC was 1.14 when compared to AC (95% CI = 1.016-1.267, p = 0.025) and 1.10 when compared to SCC, but the latter was not significant (95% CI = 0.980-1.222, p = 0.111). Conclusion: ASC is a rare tumor among esophageal carcinomas with a greater burden of metastatic disease than AC or SCC and worse OS than AC.

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Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

et al. 2017

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“…Most descriptions of this variant of esophageal cancer consist of case reports or small case series (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). While most reports from the western world are single cases, recently small case series have been reported from China and Japan (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of adenosquamous esophageal carcinoma

Yendamuri¹,

Malhotra²,

Hennon³

et al. 2017

J. Gastrointest. Oncol.

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Background: Current published information of adenosquamous carcinoma (ASC) of the esophagus in the United States is limited to isolated case reports. We sought to study the clinical characteristics of this tumor using the Surveillance, Epidemiology and End Results (SEER) database.Methods: Relevant data of all patients with esophageal cancer in the SEER database diagnosed from 1998-2010 was obtained. Demographic, grade, stage, treatment and survival characteristics of patients with ASC were summarized and compared to those patients with adenocarcinoma (ACA) and squamous cell carcinoma (SqCC). Univariate analyses across comparison groups were performed using Wilcoxon rank sum test for continuous covariates and the Pearson Chi-square test for categorical covariates. To evaluate the association of selected covariates to survival by histology, unadjusted and adjusted proportional hazards models were generated for the entire study population. To further control for the difference in covariates among the histology groups, propensity weighted Cox regression modeling was performed using the inverse propensity to treat weighting (IPTW) approach. Conclusions: ASC of the esophagus is a rare histological variant comprising 1% of esophageal ACA in the Unites States. This histological subtype presents in later stages, at a higher grade and portends a poorer survival than the more common ACA. Radiation therapy and surgical resection of appropriate stage patients provide the best chance of survival.

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“…In addition, the tumor was surrounded by Barrett's mucosa of the distinctive type with dysplasia, and no lymph node metastasis was identified is unclear why an adenosquamous carcinoma developed in the Barrett's mucosa of this particular patient. Only 5 case reports of Barrett's AC including SCC components were found in previous literature as shown in Table 1, suggestive of a rare histological type of cancer [3,[6][7][8][9]. The cases were found mainly at the advanced stage, and had a poorer prognosis.…”

Section: Discussionmentioning

confidence: 84%

“…Therefore, a non-adenocarcinomatous component such as a squamous cell carcinoma (SCC) is a rare malignant tumor in Barrett's esophagus [3] that simultaneously contains histological features of an AC and SCC. Furthermore, it is difficult to identify its origin and histopathogenesis, because these tumors contain several phenotypes of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

A rare case of Barrett’s adenocarcinoma including squamous cell carcinoma component

Mishima

Amano

Yuki

et al. 2010

Clin J Gastroenterol

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We present a rare case of Barrett's cancer with a particular histology composed of various differentiated adenocarcinoma (AC) and squamous cell carcinoma (SCC) cells. A 52-year-old man with a long-standing complaint of heartburn visited a medical center for an annual check-up by esophagogastroduodenoscopy (EGD). Although high-grade reflux esophagitis with Barrett's esophagus was identified 3 years earlier, he had not visited a hospital for medication. In 2008, he underwent EGD and a 0-IIa + IIc type of superficial cancerous lesion was found in the long segment of Barrett's esophagus. The histology of this lesion was confirmed as adenosquamous carcinoma by biopsy specimens. Based on the results of computed tomography, endoscopic ultrasonography, and a barium study, the cancer was found to invade the submucosal layer, and the patient underwent surgery. A histological study after the surgery demonstrated various subtypes of AC, such as mucinous, signet-ring cell and tubular AC, with a focal SCC component. Barrett's AC containing SCC is very rare, and its carcinogenesis is of interest.

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Adenosquamous carcinoma arising in Barrett's esophagus

Cited by 25 publications

References 9 publications

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

Clinical characteristics of adenosquamous esophageal carcinoma

A rare case of Barrett’s adenocarcinoma including squamous cell carcinoma component

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