A rare case of Barrett’s adenocarcinoma including squamous cell carcinoma component

Mishima, Yoshiyuki; Amano, Yuji; Yuki, Takafumi; Kusunoki, Ryusaku; Oka, Akihiko; Uno, Goichi; Ishimura, Norihisa; Hamaoka, Mamiko; Ishikawa, Noriyoshi; Ishihara, Shunji; Kinoshita, Yoshikazu

doi:10.1007/s12328-010-0192-7

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…In addition, carcinoma containing coexisting elements of infiltrating adenocarcinoma and SCC in the background of Barrett's mucosa is extremely rare. Thus far, only six cases of BAC containing elements of SCC have been reported (Table) (6)(7)(8)(9)(10)(11), making the present case the seventh case of such carcinoma. According to the guidelines for clinical and pathological studies of carcinomas of the esophagus established by the Japan Esophageal Society (4), adenosquamous carcinoma of the esophagus is defined as a lesion comprising !…”

Section: Discussionmentioning

confidence: 74%

“…It was therefore defined as BAC with an SCC component according to the Japanese classification and Barrett's adenosquamous carcinoma according to the WHO classification. Thus far, only one other case of BAC with an SCC component has been reported (11). However, that case report did not mention the ratio of the SCC component, and based on the reconstructed pictures of the report, the tumor appears to have been over 20% SCC.…”

Section: Discussionmentioning

confidence: 94%

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A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component

et al. 2019

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The present report describes an extremely rare case of Barrett's adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett's esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 94%

A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component

et al. 2019

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“…Mishima et al . described an adenocarcinoma occurring in Barrett's mucosa where histological examination showed the focal squamous cell carcinoma component present within the adenocarcinoma . The Barrett's mucosa surrounding the adenocarcinoma component of the tumor displayed glandular dysplasia as a precursor to the adenocarcinoma.…”

Section: Role Of Be In Esccmentioning

confidence: 99%

Risk factors for esophageal cancer: emphasis on infectious agents

El‐Zimaity

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Ringressi

et al. 2018

Annals of the New York Academy of Sciences

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Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organisms that may affect esophageal carcinogenesis, either directly or indirectly. The organisms with potential direct effects in squamous cell carcinoma include human papillomavirus (HPV), Epstein-Barr virus, and polyoma viruses. Interestingly, HPV is now implicated in esophageal adenocarcinoma (EAC), not in its initiation but in the development of dysplasia, in which HPV33 in particular has been associated. Indirectly, Helicobacter pylori has been associated with EAC by, initially, causing increased acid secretion that increases acid reflux, and by reducing lower esophageal sphincter pressure, which increases gastroesophageal reflux; the latter increases the risk of Barrett's esophagus, and hence EAC. Conversely, subsequent atrophic gastritis may normalize that risk.

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“…Barrett´s esophagus is a well-acknowledged risk factor for esophageal AC formation; however, singular cases of SCC arising in Barrett's esophagus and/or collision tumor comprising SCC and AC elements have been documented in the literature, pointing to ambivalent carcinogenic field effects [ 1 , 2 , 3 ]. Concurrent SCC and Barrett's carcinoma has occasionally been reported in Barrett's esophagus before, however, to the best of our knowledge, not with the Barrett's segment itself [ 4 , 5 , 6 ].…”

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confidence: 99%