Adenosine protects D-galactose induced alterations in rat model of aging via attenuating neurochemical profile and redox status

Samad, Noreen; Nasir, Arooj; Rehman, Muhammad Habib ur; Bhatti, Sheraz Ahmed; Imran, Imran

doi:10.1007/s11011-022-01049-7

Cited by 3 publications

(7 citation statements)

References 65 publications

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“…Twenty-four rats were divided into following sets with n = 06 as previous studies reported ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c , Samad et al, 2021 ); (i) water + water (ii) water + M.M. (iii) water + D-Gal (iv) D-Gal + M.M.…”

Section: Methodsmentioning

confidence: 99%

“…LDA and EPM tests were conducted to monitor the anxiety profile. Behavioral method used by Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c was used. For LDA, the box was comprised of two compartments (one was transparent while other was black/dark).…”

Section: Methodsmentioning

confidence: 99%

“…Aging progression is associated with many neurological problems i.e. anxiety, depression ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c , Samad et al, 2021 ), cognitive impairment ( Samad et al, 2020 ; 2019) etc. D-galactose (D-Gal) model is one of the progressive aging models, having lesser side effects and mortality rate ( St-Pierre et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, intoxication of D-gal can cause alteration at central and peripheral levels ( Samad et al, 2019 ). Administration of D-Gal causes depression ( Samad et al, 2019 , Liaquat et al, 2019 ), anxiety ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c , Hakimizadeh et al, 2021 ) and impaired cognition ( Ali et al, 2021 , Yang et al, 2016 ). Previously it was observed that increased ROS contents can cause neuro-inflammation and dysregulation of apoptosis and various neural proteins such as brain derived neuro-trophic factor, which associated with memory alterations ( Gao et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is highlighted in a study that D-Gal declined the number of neurons in brain and impaired the process of learning and memory ( Prajit et al, 2020 ). D-Gal induced alterations in brain at molecular and cellular levels were observed in experimental models which linked with natural progression of aging ( Samad et al, 2022a , Samad et al, 2022b , Samad et al, 2022c ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

Samad,

Azdee,

Imran

et al. 2023

Saudi Journal of Biological Sciences

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

Samad,

Azdee,

Imran

et al. 2023

Saudi Journal of Biological Sciences

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S-adenosylmethionine improves cognitive impairment in D-galactose-induced brain aging by inhibiting oxidative stress and neuroinflammation

Zhang

Deng

et al. 2023

Journal of Chemical Neuroanatomy

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Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Jeefoo,

Phachonpai,

Duangjai

et al. 2023

Trends Sci

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The induction of neurotoxicity by d-galactose (D-Gal) is a widely recognized model that is utilized for investigating the process of aging and the associated cognitive impairment, as well as oxidative damage and cholinergic dysfunction. Eggplant fruit is a highly consumed vegetable owing to its high phenolic content, which exhibits antioxidant properties. The current investigation aimed to assess the effect of an aqueous extract of Thai purple eggplant (PEP) fruit (Solanum melongena L., ‘Ma Khuea Muang’) on memory impairment and explore the underlying mechanisms. The quantification of total phenolic contents was conducted on the PEP extract, and an analysis of its antioxidant activity was performed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-Azino-bis (3-ethyl benzothiazoline-6-sufonic acid) (ABTS) scavenging assays. Male Wistar rats were subcutaneously (s.c.) injected (150 mg/kg/day) with D-Gal to generate a model of accelerated aging and administered orally with EP extract (250, 500, and 1,000 mg/kg/day) or donepezil (DNP) (3 mg/kg/day) for 8 weeks. Cognitive performance was evaluated by the Morris water maze (MWM) and novel object recognition (NOR) tests. Malondialdehyde (MDA) level and acetylcholinesterase (AChE) and superoxide dismutase (SOD) activities in the hippocampus were also evaluated after the behavioral studies. The continuous administration of PEP extract at a dosage of 1,000 mg/kg/day or DNP resulted in the amelioration of cognitive impairment and the reversal of the increase in AChE activity caused by D-Gal in the hippocampus. Furthermore, the administration of PEP extract resulted in a significant reduction in MDA levels in the hippocampus. These findings suggest a potential attenuation of oxidative stress. The findings indicate that the PEP extract has a beneficial effect on cognitive decline induced by D-Gal, which is attributed to the restoration of cholinergic function and the reduction of oxidative damage. HIGHLIGHTS In D-galactose-induced aged rats, purple eggplant (Solanum melongena) (PEP) extract can inhibit elevated acetylcholinesterase (AChE) activity and malondialdehyde (MDA) levels in the hippocampus. The consumption of PEP extract has been found to have potential benefits in improving age-related learning and memory impairment. The utilization of PEP extract as a dietary supplement may serve as a viable option for the elderly population in the prevention of dementia. GRAPHICAL ABSTRACT

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Adenosine protects D-galactose induced alterations in rat model of aging via attenuating neurochemical profile and redox status

Cited by 3 publications

References 65 publications

Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

Mitigation of behavioral deficits and cognitive impairment by antioxidant and neuromodulatory potential of Mukia madrespatana in D-galactose treated rats

S-adenosylmethionine improves cognitive impairment in D-galactose-induced brain aging by inhibiting oxidative stress and neuroinflammation

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

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