Adenosine diphosphate induced platelet aggregation in myocardial infarction and ischemic heart disease

Dreyfuss, F; Zahavi, J.

doi:10.1016/0021-9150(73)90139-1

Cited by 60 publications

(14 citation statements)

References 24 publications

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“…Several investigators have suggested platelet function abnormalities in coronary heart disease (2,7,20), Animal experiments also imply a relationship between platelet aggregation and myocardial necrosis (5,6,12). Our study was designed to examine the influence of the diseased coronary circulation per se on platelet aggregation.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet function has been reported abnormal in patients with certain ischemic disorders such as coronary artery disease (2,7,14,20) and cerebrovascular accidents (22). Abnormal platelet function has also been found in association with hyperlipidemia (1), diabetes mellitus (8) and hypertension (17), which are risk factors in the development of ischemic syndromes.…”

Section: Introductionmentioning

confidence: 99%

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Differences in platelet aggregation in coronary sinus and aortic blood in patients with coronary artery disease: Effect of propranolol

Mehta

Pepine

et al. 1978

Clinical Cardiology

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Summary: Platelet aggregation was studied in aortic and coronary sinus blood samples obtained from 18 patients with coronary artery disease (CAD). Using epinephrine and ADP as aggregating agents, platelet aggregation was lower in coronary venous blood than in aortic blood. In nine patients on long-term propranolol therapy, platelet aggregation was lower in both aortic and coronary venous blood compared to the nine patients not taking propranolol. Four other subjects without angiographic evidence of coronary disease exhibited no difference in platelet aggregation in aortic and coronary sinus blood. These data suggest that platelet aggregation is lower in the coronary venous blood of certain patients with coronary disease and chronic propranolol treatment may reduce aggregation in both aortic and coronary sinus blood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in platelet aggregation in coronary sinus and aortic blood in patients with coronary artery disease: Effect of propranolol

Mehta

Pepine

et al. 1978

Clinical Cardiology

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“…An increase in ADP-induced platelet aggregation for the male subjects through the two dietary periods suggests that the diet eliminated the sex difference noted at the beginning of the study. An increased susceptibility to ADP aggregation [8,25] has been reported in occlusive arterial disease.…”

Section: Discussionmentioning

confidence: 99%

Decreased Susceptibility to Thrombin and Collagen Platelet Aggregation in Man Fed a Low Fat Diet

Iacono¹,

Binder²,

Marshall³

et al. 1974

Pathophysiol Haemos Thromb

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A study was conducted in seven males and eight females to determine the effect of feeding 25 and 35% fat calories on plasma lipids, blood clotting parameters and platelet aggregation. A statistically significant reduction in thrombin- and collagen-induced aggregation was observed at the end of the 25 %-fat-calorie period. At the end of the 35 %-fat-calorie period the thrombin- and collagen-induced aggregation tests rebounded to the predietary level. Platelet counts rose significantly and white blood cell counts decreased by the end of the 25 %-fat-calorie period. Both platelet counts and white blood cell counts returned to predietary levels at the end of the 35 %-fat-calorie period. Plasma cholesterol decreased an average 15% at the end of the 25 %-fat-calorie period and remained at the lowered level throughout the 35 %-fat-calorie period. It is suggested that levels of total and saturated fat in the diet are significant factors affecting the aggregation tendency of blood platelets.

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“…13 Angiography shortly after infarction has demonstrated coronary artery occlusion in a high proportion of patients, 14 and studies of men shortly after infarction have shown enhanced platelet activity. 15 Platelets may also play a key role in sudden death, either by the obstruction of microcoronary vessels with aggregates 16 or by vasospasm induced by thromboxane A 2 released by platelets. 17 The protective effect of aspirin against myocardial infarction 1819 provides further evidence supportive of a major role of platelets in infarction.…”

Section: Discussionmentioning

confidence: 99%

Whole blood impedance platelet aggregometry and ischemic heart disease. The Caerphilly Collaborative Heart Disease Study.

et al. 1990

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The Caerphilly Collaborative Heart Disease Study is based on a large cohort of men who were ages 49 to 64 years at the time of the study. We report the results for platelet aggregation measured in whole blood from a subsample of 308 men. The index of sensitivity used was the minimum concentration of adenosine diphosphate that produced a defined degree of impedance change in the Chronolog 560 aggregometer. There was a marked association between aggregation and prevalent ischemic heart disease (IHD). The odds ratios and 95% confidence intervals (Cl) for prevalent IHD in men with the most sensitive platelets compared with those with the least sensitive platelets were 3.6 (95% Cl: 1.1 to 12.2) for angina; 7.3 (95% Cl: 2.0 to 24.3) for previous myocardial infarction (Ml); and 2.7 (95% Cl: 1.0 to 7.6) for electrocardiogram evidence of ischemia. The confidence limits for these odds ratios are large because of the small sample size, but the estimates of odds ratio are relatively large compared to similar relationships between the traditional risk factors of serum cholesterol, blood pressure, smoking, and prevalent IHD (1.5 to 2.5). A number of factors that might confound the relationships between platelets and IHD were examined, but the associations remained statistically significant when these were taken into account. (Arteriosclerosis 10:1032-1036, November/December 1990) E vidence is accumulating that platelets play a key role in ischemic heart disease (IHD). Case-control studies demonstrate positive relationships between increased platelet aggregation and IHD 12 but of course suffer from the inferential dilemma of whether differences in platelet aggregation preceded the IHD event or were caused by it.Platelet aggregability is usually assessed by turbidimetric methods with the use of platelet-rich plasma (PRP) prepared by centrifugation and diluted to a standard platelet concentration. These preparatory procedures are likely to modify the subsequent behavior of the platelets, and in addition to this, red blood cells and other components of whole blood that may affect platelet behavior are removed and are not involved in the test. A more realistic procedure for public health screening would seem to be the testing of platelets in whole blood. In this article, we report the association between aggregation measured in whole blood by an impedance method and IHD in a population sample of older men. MethodsIn the Caerphilly Heart Disease Study, 3 a major emphasis is put on tests of hemostasis, including the measurement of platelet aggregation to adenosine diphosFrom the MRC Epidemiology Unit, Cardiff, South Wales, UK, and INSERM, Unite 63, Bron, France.Stephen Rogers is now at the Institute of Medical Research, Tari, Papua New Guinea.Address for correspondence: Dr. P.C. Elwood, MRC Epidemiology Unit, 4 Richmond Road, Cardiff CF2 3AS, South Wales, UK.Received January 18, 1990; revision accepted May 1, 1990. phate (ADP) in PRP. Toward the end of the second phase of examinations of the men in this cohort, resources became a...

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Adenosine diphosphate induced platelet aggregation in myocardial infarction and ischemic heart disease

Cited by 60 publications

References 24 publications

Differences in platelet aggregation in coronary sinus and aortic blood in patients with coronary artery disease: Effect of propranolol

Differences in platelet aggregation in coronary sinus and aortic blood in patients with coronary artery disease: Effect of propranolol

Decreased Susceptibility to Thrombin and Collagen Platelet Aggregation in Man Fed a Low Fat Diet

Whole blood impedance platelet aggregometry and ischemic heart disease. The Caerphilly Collaborative Heart Disease Study.

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