Decreased Susceptibility to Thrombin and Collagen Platelet Aggregation in Man Fed a Low Fat Diet

Iacono, James M.; Binder, Richard A.; Marshall, M.; Schoene, Norberta W.; Jencks, J.A.; Mackin, J.F.

doi:10.1159/000214069

Cited by 12 publications

(3 citation statements)

References 19 publications

(23 reference statements)

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“…In man, although it has been shown that drastic changes in the diet might modify platelet functions (Iacono 1975, O'Brien et al 1976) over a short period of time, it is practically unknown whether populations differing in their intake of saturated fats (and probably also differing in their susceptibility to coronary heart disease) present differences in their platelet functions.…”

Section: Introductionmentioning

confidence: 99%

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

et al. 1978

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SummaryTo determine whether the long-term feeding of dietary fats affect platelet functions in man, platelet aggregation (to thrombin ADP, collagen, epinephrine) and clotting activity of platelet-rich plasma (PRP), platelet-poor plasma and of washed platelets, were studied in a mobile-laboratory in 44 healthy male farmers (40-45 years) from two French regions Var and Moselle, in relation to lipemia, glycemia, dietary nutriments, and platelet phospholipid composition. In the Moselle subjects, the platelet clotting activity of PRP and of washed platelets, the platelet aggregation to thrombin and ADP, were highly significantly (p <0.001) increased as compared to those of Var, but not the plasma cholesterol, which was identical in the two regions.In Moselle, the intake of total calories, total lipids and saturated fats was higher than in the Var.However, it was only with the saturated fat intake (mostly stearic acid) that the platelet clotting activity (p <0.01) and the platelet aggregation (p <0.001) were highly significantly correlated. The platelet clotting activity was also significantly (p <0.001) correlated with the fatty acid composition of the platelet phospholipid fractions phosphatidyl serine + phosphatidyl inositol.

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Section: Introductionmentioning

confidence: 99%

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

et al. 1978

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“…With this therapeutic dosage, we observed an increase in GLA and DGLA in erythrocyte membrane phospholipids and an increase in the DGLA/AA ratio but no effect on platelet aggregation and the in vivo 11 dehydrothromboxane B2 level. It is possible that the observed increase in platelet aggregation in Barre's study is not related to the intake of specific components (GLA) of borage oil at all but is related to a substantial additional fat intake (24 g/day), as Iacono et al(1974) reported that feeding high fat calories increased collagen and thrombin induced platelet aggregation.…”

mentioning

confidence: 81%

A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers

Bard

Luc

Jude³

et al. 1997

Fundamemntal Clinical Pharma

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“…They were healthy male farmers (owners of a farm) born in the same region between January 1st, 1932 and December 31,1937, and also having spent most of their life in the region.…”

Section: Human Studiesmentioning

confidence: 99%

Dietary Fats and Platelet Functions in Relation to Atherosclerosis and Coronary Heart Disease

Renaud¹,

Morazain²,

McGregor³

et al. 1979

Pathophysiol Haemos Thromb

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Results in animals and in man indicate that in many circumstances, lipemia is not closely related to the severity of atherosclerosis nor to the incidence of coronary heart disease (CHD) or the intake of saturated fats as observed in paired studies between farmers from Moselle and Var in France and from West and East Scotland. In rabbits, an increased response of platelets to thrombin occurs before any deposition of cholesterol, as a result of a saturated fat feeding. Under these conditions, the addition of alcohol to the drinking water decreases significantly both the platelet response to thrombin and the severity of atherosclerotic lesions without much affecting plasma cholesterol. In farmers from Moselle and Var (as well as from Scotland), platelet functions, namely the aggregation to thrombin and their clotting activity, i.e. PF₃, are closely related to the intake of saturated fats, either as a result of the long-term feeding or of a 1 year change in the diet of Moselle farmers. Certain platelet functions appear to be the only blood parameter related to the incidence of CHD and significantly correlated on a group, as well as on an individual basis, with the intake of saturated fat, and inversely related with that of calcium. Saturated fats and calcium are known to be the two main dietary factors related to CHD. These results suggest that the intermediate link between dietary fats and CHD might be blood platelets rather than serum lipids, through an effect on both thrombosis and atherosclerosis.

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Decreased Susceptibility to Thrombin and Collagen Platelet Aggregation in Man Fed a Low Fat Diet

Cited by 12 publications

References 19 publications

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers

Dietary Fats and Platelet Functions in Relation to Atherosclerosis and Coronary Heart Disease

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