1990
DOI: 10.1093/clinchem/36.12.2144
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Adenosine deaminase in pregnancy serum

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Cited by 27 publications
(7 citation statements)
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“…Despite some discrepant results [30], this reduction in ADA activity seems to depend mainly on the soluble isoform of ADA (ADA2) rather than membrane-linked ADA (ADA1) [31]. Additionally, total ADA activity is high during the first and second trimesters but not during the third trimester [24,32]. Our results are in agreement with this last analysis, as a trend toward reduced ADA activity was only observed in pregnant women in their third trimester compared to control women.…”
Section: Adenosine In Pregnancysupporting
confidence: 84%
“…Despite some discrepant results [30], this reduction in ADA activity seems to depend mainly on the soluble isoform of ADA (ADA2) rather than membrane-linked ADA (ADA1) [31]. Additionally, total ADA activity is high during the first and second trimesters but not during the third trimester [24,32]. Our results are in agreement with this last analysis, as a trend toward reduced ADA activity was only observed in pregnant women in their third trimester compared to control women.…”
Section: Adenosine In Pregnancysupporting
confidence: 84%
“…There have been conflicting reports about the changes in the activity of serum ADA in normal pregnancy compared to the age-matched non-pregnant women ( 14 - 16 ). However, to our knowledge, only few studies have been performed investigating the changes in serum ADA activity according to gestational age, and the clinical significance of changes in ADA activity throughout normal pregnancy has not been elucidated ( 14 , 15 ). Several studies have shown that serum ADA activity is significantly increased in women with recurrent spontaneous abortions, preeclampsia, and hyperemesis gravidarum where enhanced cell-mediated immunity is thought to be an important pathogenesis ( 17 - 19 ).…”
Section: Introductionmentioning
confidence: 99%
“…In our present study however, the absolute figures are higher compared to their figures of 14IU/L in the normal non pregnant and 10.5IU/L in the normal pregnant group. In a another study in which ADA was assessed in the three trimesters of pregnancy, Jaqueti et al 7 reported a significant decrease in ADA activity in pregnancy compared to the nonpregnant controls but no significant difference in ADA activity between the three trimesters.…”
Section: Discussionmentioning
confidence: 96%
“…1,3 Changes in serum ADA have been associated with diseases in which there is involvement of cellular immunity 5,6 Although Pregnancy is a physiological state, it has been associated with depressed cellular mediated immunity. 7,8 Hypertension in pregnancy and preeclampsia are frequent complications of pregnancy. 9 Hypertension complicates 6-20% of pregnancies all over the world and is a common cause of maternal and perinatal mortality.…”
Section: Introductionmentioning
confidence: 99%