Adenosine deaminase and protein pattern in serum and cerebrospinal fluid in experimental manganese encephalopathy

Mustafa, S. Jamal; Chandra, Satya V.

doi:10.1007/bf00330061

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…However, some biochemical changes in manganese toxicity have been found useful in assessing early manganese Industrial Health 2005, 43, 663-668 poisoning. Studies conducted in experimental animals 9,10) and suspected cases of manganese poisoning 11) revealed that serum calcium, inorganic phosphate and adenosine deaminase are some of the biochemical changes that could possibly be used in the early detection of manganese poisoning. The elevated level of serum prolactin 12) and the increased activity of lymphocytes manganese-dependent superoxide dismutase (MnSOD) in conjugation with higher concentration of blood manganese 13) have been suggested as useful peripheral biomarkers of manganese exposure.…”

Section: Introductionmentioning

confidence: 99%

Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins

Zaidi¹,

Patel²,

Mehta

et al. 2005

Ind Health

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Manganese-induced early biochemical changes and effects of supplementation of magnesium nitrate (Mg(NO 3 ) 2 ) and antioxidant vitamins (A, C, D and E) were studied in rats intoxicated with manganese. Significant elevation in the level of chlorides in plasma, erythrocytes, liver and cerebellum, and a decrease in plasma inorganic phosphate (pi) with an increase in liver pi were observed in animals exposed to manganese as compared to controls. The level of erythrocyteacid labile phosphate (ALP), nicotinamide adeninedinucleotide (NAD + ) and plasma sialic acid (Nacetylneuraminic acid, NANA) also increased significantly. Elevated levels of chlorides in plasma, erythrocytes and cerebellum reversed to normal control values whereas liver chlorides restored partially by the supplementation of Mg(NO 3 ) 2 . Vitamins supplementation was effective to reverse chlorides level in erythrocytes, liver and cerebellum. Decreased level of pi in plasma and the highly elevated level of erythrocyte ALP were also recovered in animals received Mg(NO 3 ) 2 in addition to MnSO 4 . However, such effect of Mg(NO 3 ) 2 was not seen in lowering the elevated level of NANA that restored by the administration of vitamins. Thus, the early alterations in plasma levels of chlorides, pi, and NANA and erythrocyte-ALP seem to be an indicative of early manganese toxicity while Mg(NO 3 ) 2 and vitamins supplementation appear to provide, at least in part, protection against manganese toxicity.

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Section: Introductionmentioning

confidence: 99%

Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins

Zaidi¹,

Patel²,

Mehta

et al. 2005

Ind Health

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Manganese poisoning: Clinical and biochemical observations

Chandra

Seth

Mankeshwar

1974

Environmental Research

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Effect of Manganese on Enzymes in Rat Brain

Sitaramayya

Nagar

Chandra

1974

Acta Pharmacologica et Toxicologica

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Rats were given MnCl2.4H2O (8 mg/kg) intraperitoneally daily for 120 days, and then sacrificed by decapitation. The brain was removed and dissected into three regions; cerebral cortex, cerebellum and remainder of the brain. Enzymic studies were conducted in these regions and compared with control animals. The activities of acetyl choline esterase and adenosine deaminase were significantly reduced in all the three regions. The activity of monoamine oxidase was increased in the cerebellum while the activity of guanine deaminase decreased in the cerebellum and remainder of the brain. The analysis of the results allows no overall generalization in enzymic alterations induced by manganese chloride in the three regions of the rat brain.

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Adenosine deaminase and protein pattern in serum and cerebrospinal fluid in experimental manganese encephalopathy

Cited by 5 publications

References 11 publications

Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins

Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins

Manganese poisoning: Clinical and biochemical observations

Effect of Manganese on Enzymes in Rat Brain

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