Adenosine deaminase activity in type 2 diabetes mellitus

Aruna, S.; Suchitra, MM; Suresh, V

doi:10.15380/2277-5706.jcsr.17.09.002a

Cited by 2 publications

(1 citation statement)

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“…ADA is an essential enzyme for regulating the bioactivity of insulin [12]. The anti-inflammatory effect is found to exert adenosine, and therefore the inflammatory response is regulated by ADA [13]. The increased ADA level indicates the increased insulin resistance and immuno-pathogenesis of type 2 diabetes mellitus [14].…”

Section: Introductionmentioning

confidence: 99%

Serum Adenosine Deaminase and C - reactive protein in Diabetic patients with and without Neuropathy

Khan

Muraleedharan

Velladath

et al. 2021

Clinical Diabetology

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Background. Diabetic Peripheral Neuropathy (DPN) is one major microvascular complication of long-standing diabetes mellitus with a prevalence of 50-60%. DPN leads to decreased quality of life, increased morbidity, and mortality. C reactive protein (CRP) and adenosine deaminase (ADA) are independent inflammatory markers; the current study aims to evaluate and compare serum ADA, CRP in diabetic patients with and without neuropathy. Methods. A prospective study was done on 160 diabetic patients with and without neuropathy who visited the Medicine Department of Kasturba Hospital Manipal. Patients were grouped into two: diabetics with neuropathy (n = 80) and without neuropathy (n = 80). Serum samples were collected and analyzed for CRP and ADA. Results. The data were analyzed using the independent t-test and Mann-Whitney U test. There was a significantly high level of ADA (P = 0.032) in neuropathy patients when compared with the non-DPN group. No significant difference was seen in CRP levels (P = 0.123) in DPN patients compared to non-DPN patients. Conclusion. Monitoring of inflammatory markers likeADA in diabetic patients can provide insight into preventing DPN and its associated complications.

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Section: Introductionmentioning

confidence: 99%