Adenomyomatous Hamartoma of Lung Mimicking Benign Mucinous Tumor in Fine Needle Aspiration Biopsy

Jin, Min; Ha, Hwa-Jeong; Baek, Hong Sun; Lee, Jae Cheol; Koh, Jae Soo

doi:10.1159/000325523

Cited by 11 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the mucinous proliferation described in these cases had a benign behavior. Our cases were more similar to those described by Itoh et al 18 and Jin et al 8 In both studies, the mucinous glands had an irregular architecture and distribution in the smooth muscle, and were characterized by a mucinous columnar cell with goblet cell appearance without atypia or mitotic figures. No basal cell layer was described in these 2 reports, but no staining with p63 or other basal cell markers was included.…”

Section: Discussionsupporting

confidence: 90%

“…A series of 6 patients with a solitary, peripheral PH consisting of a predominant smooth muscle proliferation strikingly associated with a proliferation of irregularly shaped and disperse mucinous columnar glands is reported in this article. Similar cases have been previously described under various names/definitions, such as “adenoleiomyomatous hamartoma,” “fibroleiomyomatous hamartoma,” “cystoadenomatous hamartoma,” and “pulmonary hamartoma with mucous glands.” 8,16-20 Another interesting case consisting of predominant mucous glands with a minority of smooth muscle was reported by Zhang et al 21 as “peripheral mucous gland adenoma with smooth muscle stroma.”…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Mucinous Adenomyomatous Pulmonary Hamartoma: Clinicopathologic, Immunohistochemical, and Molecular Features of 6 Cases

et al. 2020

View full text Add to dashboard Cite

Pulmonary hamartoma (PH) may show various combinations of mesenchymal tissues with entrapment of respiratory epithelium. An uncommon variant of PH prevalently consisting of smooth muscle with mucinous proliferation has been reported in literature under several definitions as sporadic reports. We collected a series of 6 leiomyomatous PH associated with mucinous growth from consultation files (3 cases) and multicentric revision of archival files among 128 consecutive surgically resected PH. The lesions have a prevalence for male gender (5:1) and lower lobes (5:1), with a mean age at diagnosis of 61 years. All cases were incidentally disclosed in asymptomatic patients and had an indolent behavior. At histology, 2 cases consisted uniquely of smooth muscle and 4 also showed mature adipose tissue. The mucinous proliferation consisted of a monotonous growth of columnar cells lacking p63-positive basal cells and expressing pan-CKs, MUC5A, and CK7, but negative with TTF-1, napsin, MUC1, MUC2, MUC6, CK20, and CDX2. Smooth muscle was negative with hormonal receptors. Molecular analysis using a multiplex gene panel did not reveal gene mutations, while ALK, BRAF, and ROS1 were negative. In conclusion, we describe a small series of uncommon PH with prevalent leiomyomatous mesenchymal component associated with a mucinous growth (mucinous adenomyomatous hamartoma). Despite the lack of basal cells coating mucinous proliferation and irregular architecture, the favorable outcome and lack of molecular alterations most likely lay for a benign/low-grade tumor. Pathologists should be aware of this unusual occurrence to prevent a diagnosis of overt malignancy, particularly in frozen section, small biopsy, and cytology.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

Mucinous Adenomyomatous Pulmonary Hamartoma: Clinicopathologic, Immunohistochemical, and Molecular Features of 6 Cases

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A major study of PH showed that 86.9% of PH comprised epithelial components . Although no reports have described the proportion of epithelial components in detail, a few cases of PH show prominent epithelial entrapments . This rare variant of PH, which is composed of smooth muscle fascicles and tubular or cleft‐like entrapped epithelial components without other mesenchymal components, has been described using different diagnostic terms, including fibroleiomyomatous hamartoma, hamartoma, adenomyomatous hamartoma, or adenofibroma .…”

Section: Discussionmentioning

confidence: 99%

“…1 Although no reports have described the proportion of epithelial components in detail, a few cases of PH show prominent epithelial entrapments. 9,10 This rare variant of PH, which is composed of smooth muscle fascicles and tubular or cleft-like entrapped epithelial components without other mesenchymal components, has been described using different diagnostic terms, including fibroleiomyomatous hamartoma, hamartoma, adenomyomatous hamartoma, or adenofibroma. 9,10 To the best of our knowledge, PH with predominant bronchial mucous glands has not been reported to date and this is the first such case report.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung

Yamada

Tonooka

Horiguchi

et al. 2018

Pathology International

View full text Add to dashboard Cite

Pulmonary hamartoma (PH) is the most common benign lung tumor, comprising various amounts of mescenchymal components with entrapped epithelial components. We describe an unusual case of PH in the left lower lung lobe of a 60-year-old female. The tumor was 9 × 9 mm in size, light brown, weakly glistening, and microscopically found to be composed of well-developed epithelial and mesenchymal components without atypia. Both components were intermingled but without apparent transition. Epithelial components were occupied by predominant bronchial mucous glands. Serous glands, entrapped bronchioles, and clefts lined by respiratory epithelium were also apparent. Mesenchymal components including cartilage and fat were scattered, and swirling smooth muscle fascicles were interlaced with epithelial components. Collision tumor or other biphasic tumors were unlikely, and hyperplastic change in bronchial glands as in the rare conditions of intraoral minor salivary glands and epithelial entrapments by PH may explain these interesting histological findings. It is important to be aware of the possibility that a large number of bronchial mucous glands may be noted in the peripheral lung, and not to mistake this for other malignancies.

show abstract

“…The differential diagnoses based on the cytologic features were mucin-rich lesions including mesenchymal tumors such as myxoma, hamartoma, extraskeletal myxoid chondrosarcoma (EMCS) and low cellular epithelial tumors such as mucinous epithelial tumor [ 1 , 6 , 7 ]. Cytologic findings of pulmonary hamartoma are scantly cellular smears composed of bland-looking spindle and stellate cells and fibromyxoid materials in serosanguinous background [ 6 ]. Pulmonary hamartoma is composed of predominantly chondroid connective tissue, adipocytes and fibroblasts with intervening nests of bland-looking epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

A Case of Primary Subpleural Pulmonary Microcystic Myxoma Coincidentally Occurred with Pulmonary Adenocarcinoma

Ahn

Kim

et al. 2015

J Pathol Transl Med

View full text Add to dashboard Cite

Adenomyomatous Hamartoma of Lung Mimicking Benign Mucinous Tumor in Fine Needle Aspiration Biopsy

Cited by 11 publications

References 10 publications

Mucinous Adenomyomatous Pulmonary Hamartoma: Clinicopathologic, Immunohistochemical, and Molecular Features of 6 Cases

Mucinous Adenomyomatous Pulmonary Hamartoma: Clinicopathologic, Immunohistochemical, and Molecular Features of 6 Cases

An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung

A Case of Primary Subpleural Pulmonary Microcystic Myxoma Coincidentally Occurred with Pulmonary Adenocarcinoma

Contact Info

Product

Resources

About