Adenomyoepithelioma of the breast with late pulmonary metastases – case report and review of the literature

Abstract

BackgroundAdenomyoepithelioma (AME) of the breast is a rare tumour of unpredictable clinical behaviour. Most of the tumours are benign with some giving local recurrences or distant metastases.Case PresentationWe report a case of late lung metastases in a woman with a history of breast adenomyoepithelioma. Partial lobectomy was performed for lung lesions and initial diagnosis was epithelial-myoepithelial carcinoma.ConclusionCareful slide’s revision of both breast and pulmonary lesions showed identical microscopic appearance with lung tumour performing more malignant features. Tumour cells in both: breast and pulmonary lesions were positive for cytokeratin and EMA (epithelial cells) and also for SMA, S100 and vimentin (myoepithelial cells). Two years and 7 months follow-up showed no recurrent neoplastic disease in our patient.

A case of adenomyoepithelioma with myoepithelial carcinoma of the breast

“…Patients with benign AME usually present a solitary, well‐circumscribed, and sometimes palpable nodule . Patients with myoepithelial carcinoma present the same features, along with tenderness .…”

“…The definitive diagnosis of AME and myoepithelial carcinoma is based on histological and immunohistochemical findings . AME is a tumor consisting of epithelial and myoepithelial cells and is characterized by bicellular proliferation . Myoepithelioma is a tumor that consists of myoepithelial cells but lacks epithelial cells .…”

“…Adenomyoepitheliomas is characterized by the bicellular proliferation of glands that consist of an inner epithelial and an outer myoepithelial layer of cells . It can have a spindle, tubular, or lobulated histological pattern .…”

Adenomyoepithelioma with malignant transformation and repeated local recurrence: A case report

“…Adenomyoepithelioma (AME) is as very rare type of benign tumor of the breast. Many AMEs have demonstrated benign behavior and are often cured with excision with negative margins, but some have exhibited malignant transformation of the myoepithelium, glandular epithelium, or both [1][2][3][4][5][6]. In this report, the case of a patient with repeated local recurrences and malignant transformation is presented.…”

Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur ( Lemur catta )

“…Due to its benign behaviour, complete surgical excision alone is usually an adequate treatment (Nadelman et al, 2006). However, malignant transformation of a specific component, either epithelial cells or myoepithelial cells, or both, has been documented (Yang et al, 2014;Korolczuk et al, 2016).…”