Adenomatous Polyp With Intestinal Metaplasia of the Esophagus (Barrett Esophagus) in a Dog

Gibson, Christopher J.; Parry, N.; Jakowski, R. M.; Cooper, Jeffrey T.

doi:10.1177/0300985809352973

Cited by 26 publications

(22 citation statements)

References 11 publications

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“…BE is considered a premalignant condition because of stepwise progression from intestinal metaplasia to dysplasia and finally AC (Cameron et al ) and ASC (Noguchi et al ). A case of canine BE with an oesophageal adenomatous polyp has recently been reported (Gibson et al ). In the present case, ASC might have developed from BE following irritation of the oesophageal mucosa due to chronic vomiting and regurgitation, because the oesophageal mucosa consisted of not only neoplastic but also non‐neoplastic columnar epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma of the oesophagus in a dog

Okanishi

Shibuya

Miyasaka

et al. 2015

J of Small Animal Practice

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A six-year-old mixed-breed male dog weighing 7.0 kg was presented with chronic vomiting and regurgitation. Endoscopic examination revealed prominent oesophageal dilation in the thoracic region, multiple small greyish-white nodules over the oesophageal lumen and cauliflower-like masses in the caudal oesophagus. Histopathological studies revealed a characteristic pattern of coexisting elements of infiltrating adenocarcinoma and squamous cell carcinoma. Immunohistochemical staining with anti-cytokeratin AE1 + AE3 was positive in both types of neoplastic cells. Neoplastic glandular cells stained positively for cytokeratin 8 while neoplastic squamous cells stained positively for cytokeratin 5/6. On the basis of these findings, the dog was diagnosed with oesophageal adenosquamous carcinoma. The case history and findings suggest that the malignancy might have developed from Barrett's oesophagus following irritation of the oesophageal mucosa due to chronic vomiting and regurgitation.

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Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma of the oesophagus in a dog

Okanishi

Shibuya

Miyasaka

et al. 2015

J of Small Animal Practice

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“…In dogs and cats, esophagitis and intestinal metaplasia are histological defined diseases (21)(22)(23)(24). Nevertheless, similar as in the present study, biopsies from the esophagus are rarely obtained during routine gastroscopy in veterinary practice settings.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic esophagopathies resembling gastroesophageal reflux disease in dogs

Münster¹,

Hörauf²,

Lübke‐Becker³

et al. 2013

Tierarztl Prax Ausg K

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Objective: Pathologic gastroesophageal reflux (GER) has been demonstrated experimentally in dogs, and it is suspected to occur naturally in dogs, yet its clinical significance is unknown. The aim of the study was to demonstrate clinical indicators of pathologic GER in dogs with idiopathic esophagopathies. Materials and methods: Dogs with clinical signs suggestive for esophageal disease (regurgitation, ptyalism, or dysphagia) and where extraesophageal and specific esophageal diseases had been ruled out, were retrospectively diagnosed with idiopathic esophagopathies. History, physical examination findings, clinicopathologic, radiographic, and endoscopic data, and treatment results were obtained from medical records, reviewed and evaluated. Results: Out of 67 dogs with anamnestic esophageal signs, 12 (17.4%) dogs were identified as having idiopathic esophagopathies and were included in the study. Median age was 3.0 years (range 1.0-11.0), and median bodyweight was 28.2 kg (range 8.2-44.0). The most frequent anamnestic esophageal signs were ptyalism (10/12 dogs), regurgitation (8/12 dogs), signs of discomfort, pain (8/12 dogs), and cough (5/12 dogs). The most common radiographic abnormality was segmental esophageal dilation (8/12 dogs). Esophagoscopy revealed single mucosal surface defects at the gastroesophageal junction in 3/12 dogs. In dogs with altered esophageal motility, cytological and microbiological examinations of bronchial aspirates showed goblet cell hyperplasia (8/8 dogs), neutrophilic infiltration (5/8 dogs) and culturable bacteria (4/8 dogs), respectively. All dogs were treated with omeprazole (median 0.7 mg/kg once per day, range 0.5-1.2). Reported median treatment duration until remission of the main clinical signs was 20.0 days (range 8.0-54.0 days). This endpoint was reached in 11/12 dogs. Conclusion and clinical relevance: Results suggest that in some dogs with esophageal clinical signs, and where no primary disease could be identified, clinical indicators of pathologic GER such as pain, mucosal lesions and motility disturbances of the esophagus, respiratory complications, and response to therapy can be observed.

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“…This is largely due to animals rarely developing a natural BE phenotype . In fact, there have only been three reported cases of animals developing spontaneous BE, two of which were in dogs and one in a baboon . Of the two cases reported in dogs, one also progressed to EAC .…”

Section: In Vivo Modelsmentioning

confidence: 99%

Preclinical models for the study of Barrett's carcinogenesis

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Krishnadath

Clemons

et al. 2018

Annals of the New York Academy of Sciences

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Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies.

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Adenomatous Polyp With Intestinal Metaplasia of the Esophagus (Barrett Esophagus) in a Dog

Cited by 26 publications

References 11 publications

Adenosquamous carcinoma of the oesophagus in a dog

Adenosquamous carcinoma of the oesophagus in a dog

Idiopathic esophagopathies resembling gastroesophageal reflux disease in dogs

Preclinical models for the study of Barrett's carcinogenesis

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