Adenosquamous carcinoma of the oesophagus in a dog

Okanishi, Hiroki; Shibuya, Hisashi; Miyasaka, T.; Asano, Kazushi; Sato, Tsuneo; Watari, Toshihiro

doi:10.1111/jsap.12333

Cited by 7 publications

(6 citation statements)

References 12 publications

(12 reference statements)

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“…Histologically, it is characterized by the simultaneous and distinct presence of two components: glandular and squamous (2). This neoplasm has already been described in the lung, oesophagus, and ileum (16,10,19). In the literature, there is only one report of this subtype in the oral mucosa of animals ( 1) and a retrospective study of histological subtypes of oral SCC in dogs reporting a 3,6% incidence of ASC (9).…”

Section: Discussionmentioning

confidence: 91%

Adenosquamous carcinoma in the palate of a dog: case report

Gomes¹,

Nóbrega²,

Azzem³

et al. 2022

BJVP

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Adenosquamous carcinoma is characterized by the simultaneous presence of squamous and glandular components. This article reports a case of adenosquamous carcinoma in the oral mucosa in a dog. Microscopically, the tumour revealed an infiltrative epithelial proliferation with a tubular pattern and areas of squamous differentiation. In the lumina of the tubules, there were eosinophilic material (mucin). The alcian blue staining showed positive intraluminal material and the cytoplasm of neoplastic cells were immunoreactive for cytokeratin, supporting the diagnosis of adenosquamous carcinoma. The cells exhibited reduced or negative immunoreactivity for E-cadherin, which could be associated with more aggressive tumour behaviour and worse prognosis.

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Section: Discussionmentioning

confidence: 91%

Adenosquamous carcinoma in the palate of a dog: case report

Gomes¹,

Nóbrega²,

Azzem³

et al. 2022

BJVP

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“…11 In the case reported here, no squamous differentiation or component was observed on histopathology. While mammary, 12 pulmonary [13][14][15] and oesophageal 16 ASC have been reported in dogs, pancreatic origin has not. One case of pancreatic ASC in a cat has been published.…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog

Johannes

Heinrich

Musser

et al. 2020

Vet Record Case Reports

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A 10.5-year-old, male, neutered Samoyed was presented to the Iowa State University Lloyd Veterinary Medical Center with history (including prior surgical biopsy), non-specific acute clinical signs and clinicopathology changes most consistent with pancreatitis. Marked hypercalcemia developed within a short span of time, raising clinical concerns for neoplasia. Diagnostic imaging and fine-needle aspirate cytology were consistent with pancreatitis. Marked elevation in parathyroid hormone–related protein with low parathyroid hormone further supported the diagnosis of underlying neoplasia. The dog’s clinical status declined despite aggressive medical supportive therapy. Humane euthanasia was elected. Postmortem examination revealed an extensive pancreatic neoplasm confirmed as exocrine pancreatic adenocarcinoma with diffuse intra-abdominal metastases. Acute kidney injury most likely resulted from the severe pancreatic inflammation (pancreatitis) and hypercalcemia of malignancy caused by the exocrine pancreatic adenocarcinoma. This is the first reported case of hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog.

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“…This is an unusual malignant oesophageal neoplasm in which elements of infiltrating squamous cell carcinoma (SCC) and adenocarcinoma (AC). A comprehensive literature review revealed that to date there is only one published case report of an oesophageal adenoquamous carcinoma in the caudal (thoracic) oesophagus of a dog (OKANISHI et al, 2015) and a cat (SHINOZUKA et al, 2001). purely glandular oesophageal tumors are also rare in animals and humans.…”

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confidence: 99%

Adenosquamous carcinoma of the cervical oesophagus in a dog

et al. 2020

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ABSTRACT: A 9-year-old male Shih Tzu dog presented with a mass on the ventral region of the neck and developed ptyalism. Radiographs revealed a radiodense nodule located in the mid-third of the oesophagus compressing the trachea. Preoperative cytology showed large neoplastic cells with abundant vacuolated cytoplasm arranged in clusters. The nodule was removed by oesophagectomy and submitted for histopathology. Microscopically, the oesophageal mass was multilobulated and unencapsulated. It had a mixed cellular growth pattern with areas showing squamous and glandular differentiation. The squamous component of the tumor was formed by solid strands of neoplastic epithelial cells; many neoplastic cells had undergone central keratinization and sometimes formed keratin pearls. The deeper adenocarcinomatous portion of the tumor consisted of tubules filled with slightly basophilic mucinous material. Histological and immunohistochemical examination confirmed the diagnosis of primary adenosquamous carcinoma (ASC) of the esophagus. This is the first report of primary ASC of the cervical oesophagus in a dog.

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Adenosquamous carcinoma of the oesophagus in a dog

Cited by 7 publications

References 12 publications

Adenosquamous carcinoma in the palate of a dog: case report

Adenosquamous carcinoma in the palate of a dog: case report

Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog

Adenosquamous carcinoma of the cervical oesophagus in a dog

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