Adenoid squamous cell carcinoma of the oral mucosa.Report of two autopsy cases

Takagi, Minoru; Sakota, Y; Takayama, Shojiro; Ishikawa, Goro

doi:10.1002/1097-0142(197711)40:5<2250::aid-cncr2820400535>3.0.co;2-m

Cited by 58 publications

(32 citation statements)

References 8 publications

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“…The clinical impression is most often BCC or KA. Other sites of origin have been reported, including the vulva, 82 penis, 83 oral mucosa, 84 nasopharynx, 85 and breast. 86 Histologically, the tumor consists of a nodular, epidermal-derived proliferation, forming lobules, columns, and island-like structures (Fig.…”

Section: Historical Backgroundmentioning

confidence: 99%

Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part One

2006

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Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential. However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC. No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated. Therefore, we have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior. Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC, tricholemmal carcinoma, and spindle cell SCC (unassociated with radiation). Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin. High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors. The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC. Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.

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Section: Historical Backgroundmentioning

confidence: 99%

Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part One

2006

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“…The most frequent locations include face and ears (1,3). Other cases have been observed in oral mucosa after radiation therapy (4). Acantholytic squamous carcinoma is a very rare neoplasm in the vulva, with only a few reports published in the international literature (5)(6)(7)(8)(9).…”

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confidence: 99%

Vulvar Acantholytic Squamous Carcinoma: A Case Report With Immunohistochemical and Molecular Study

Giordano

D’Adda

Merisio

et al. 2005

International Journal of Gynecological Pathology

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Acantholytic carcinoma is a subtype of squamous carcinoma, characterized by tubular and alveolar formations as a consequence of the acantholysis. We report a case of vulvar squamous acantholytic carcinoma (VSAC) in a 69-year-old woman, who was admitted to our institution for vulvar pruritus and the presence of a large, bilateral, exophytic, and ulcerated lesion, measuring 7 x 8 cm. The patient had never received vulvar or pelvic radiation therapy. Pathological examination with an immunohistochemical study showed features of VSAC and high p16 protein expression. Molecular study by polymerase chain reaction amplification of DNA tumor revealed a weakly positive signal for human papillomavirus. In conclusion, our case, which is the first case of VSAC with polymerase chain reaction analysis and immunohistochemical expression of p16 protein, suggested that this neoplasm could be related to human papillomavirus infection.

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“…Clinically, A-SCC is usually found on the sunexposed areas of elderly patients with notable male predominance. It presents most often on the head and neck, but other sites of origin have been reported, including the vulva, penis, oral mucosa, nasopharynx, and breast 1,[9][10][11][12][13] . It appears as flesh-A Case of Acantholytic Squamous Cell Carcinoma 269 colored, pink, red, or brown nodules in most cases, and it is frequently accompanied by scaling, crusting, and ulceration like the other SCC variants.…”

Section: Discussionmentioning

confidence: 99%

“…Second, most of the reported lesions located on mucosa to have a high malignant potential. Third, many patients have predisposing factors associated with metastasis (i.e., immunosuppression) 3,[5][6][7][8][9][10][11][12][13][14] . Although various reports have shown controversial results, the overall malignant potential of A-SCC seems not to be higher than that of typical invasive SCC 1,2 .…”

Section: Discussionmentioning

confidence: 99%