Adenoid Cystic Carcinoma of the Submandibular Gland: A 35‐Year Review

Abstract

C.

Carcinomas arising in the submandibular gland: High propensity for systemic failure

“…The survival of patients with salivary gland malignancies is mainly affected by pathologic subtypes. Adenoid cystic carcinoma has histologic and biologic features that generally favor higher initial survival rates, although survival rates of patients with these tumors generally decrease after 5 years, due to their propensity for distant metastases [11,13]. In contrast, salivary duct carcinomas are highly malignant, showing local invasion, extensive cervical lymph node involvement, and high rate of distant metastasis [14,15].…”

“…Salivary gland tumors may have a radiosensitivity similar to that of squamous cell carcinomas of the head and neck [20,21]. Thus, the combination of surgery and radiation therapy may achieve control of locoregional disease in salivary gland tumors [7,8,11]. In addition, previous study showed that younger age, decreased tumor grade, and radiation therapy were found to improve survival, whereas gender, tumor size, extraglandular extension, and nodal positivity did not statistically influence survival [9].…”

“…In addition, postoperative radiotherapy has been reported to increase the locoregional control rate in high-risk patients with submandibular gland cancers [7]. Because of their overall rarity, however, limited information is available on survival and prognosis for patients with cancer of the submandibular gland [3,[7][8][9][10][11]. We therefore retrospectively assessed our institutional experience with these tumors, especially patient survival and the prognostic factors affecting survival and locoregional control.…”

Resection of upper lip adenoid cystic carcinoma and reconstruction with reverse Yu flap: Report of three cases and a literature review

“…Despite wide excision, a very close follow-up of patients is required for at least 10 years in order to detect local recurrences and distant metastases (5). Postoperative radiotherapy may be indicated with positive surgical margins, or when perineural invasion or bone infiltration occur (3,10,37,(39)(40)(41).…”

Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells

“…The disease-free survival rates are 66% for 3 years, 57% for 5 years and 41% for 10 years. 5 Interest has, therefore, been in the development of new treatment modalities because of the significant limitations of currently used local and systemic therapies for ACCs. 6 Reported response rates to combination chemotherapy for ACCs are low and the response is generally short-lived.…”