Carcinomas arising in the submandibular gland: High propensity for systemic failure

Abstract

Despite effective locoregional treatment, approximately one-third of patients with submandibular gland carcinomas may fail systemically, resulting in poor survival. New, more effective therapies may be required for these patients.

Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

“…Regarding the prevalence of histologies, our data confirm that pleomorphic adenoma (PA) is by far the most common lesion in the benign subgroup (almost 90% of cases), whereas other types are less frequently encountered . The distribution of histologies in the malignant subgroup was consistent with published data, with AdCC, AcNOS, MEC, and SDC being the most frequent tumors . The most striking difference between our study and data from the literature is the rate of high‐grade lesions.…”

“…Our OS data (66.4% and 57.1% after 5 and 10 years, respectively) compare favorably with those in the literature, with 5‐ and 10‐year OS ranging between 50% and 69% and between 36% and 40%, respectively . It is noteworthy, however, that in most publications, 5‐year OS is in the 50% to 56% range; moreover, our data also confirm that the OS decrease between 5 and 10 years is generally about 12% to 14% .…”

“…Our OS data (66.4% and 57.1% after 5 and 10 years, respectively) compare favorably with those in the literature, with 5‐ and 10‐year OS ranging between 50% and 69% and between 36% and 40%, respectively . It is noteworthy, however, that in most publications, 5‐year OS is in the 50% to 56% range; moreover, our data also confirm that the OS decrease between 5 and 10 years is generally about 12% to 14% . Not unexpectedly, OS was affected, on univariate analysis, by pT status, pN status, PNS, facial nerve palsy, and pain at presentation, thus confirming the results of previous studies in which high pT category (pT3–4), nodal involvement, and PNS were the factors associated with dismal prognosis .…”

Métastase d’un cancer du sein dans la glande submandibulaire : un nouveau cas

“…Les tumeurs malignes des glandes salivaires sont rares et touchent les hommes et les femmes de façon identique [5] ; elles représentent 1 à 4 % des tumeurs de la tête et du cou et approximativement 0,4 % de toutes les tumeurs [6][7][8]. 10 à 15 % de ces tumeurs malignes des glandes salivaires intéres-sent les glandes submandibulaires [7][8][9] et 10 à 15 % de ces tumeurs sont des métastases.…”

“…10 à 15 % de ces tumeurs malignes des glandes salivaires intéres-sent les glandes submandibulaires [7][8][9] et 10 à 15 % de ces tumeurs sont des métastases. Les tumeurs des glandes submandibulaires sont plus rares que les tumeurs des glandes parotides mais elles sont plus souvent malignes que ces dernières (elles sont malignes dans environ 50 % des cas et seulement dans 25 % des cas pour les glandes parotides) [2][3][4][5][6][7][8][9][10].…”