Adenoid cystic carcinoma of the external auditory canal successfully diagnosed by fine‐needle aspiration

Kagotani, Akiko; Ishida, Mitsuaki; Yoshida, Keiko; Okabe, Hidetoshi

doi:10.1002/dc.22909

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The typical cytological features of conventional low‐grade AdCC are as follows: (i) spherical globules surrounded by cohesive, uniform, round tumor cells and (ii) tumor cells with scant cytoplasm, hyperchromatic nuclei, and inconspicuous nucleoli . These features are identical to those in most of the cytological specimen in our case.…”

Section: Discussionsupporting

confidence: 72%

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Cytological features of dedifferentiated adenoid cystic carcinoma of the trachea

Kagotani

Ishida

Yoshida

et al. 2013

Diagnostic Cytopathology

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Adenoid cystic carcinoma (AdCC) is a distinct type of carcinoma, and cytological examination has been recognized as a useful tool in its diagnosis. Dedifferentiation is defined as the abrupt transformation of a low-grade tumor into a tumor with high-grade components. Albeit extremely rare, dedifferentiated AdCC has been reported: however, the cytological features of this tumor have not been documented. We observed a case in which a 66-year-old Japanese male had stenosis and thickness of the lower tracheal and bronchial walls. Cytological smears of a bronchial brush specimen revealed features typical for low-grade AdCC. However, a few cohesive epithelial cell clusters composed of large, atypical polygonal cells with large nuclei and conspicuous nucleoli also were present. This component was considered to represent dedifferentiated carcinoma. Histopathological study of the resected bronchial tumor revealed dedifferentiated AdCC. The cytological diagnosis of conventional low-grade AdCC is straightforward in most cases, although extremely rare, dedifferentiated carcinoma can occur within the conventional AdCC, and detection of a dedifferentiated component is possible in a cytological specimen because of obvious nuclear atypia. Therefore, careful observation is needed because cytologic diagnosis of dedifferentiated AdCC can help expedite treatment of this highly aggressive tumor.

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Section: Discussionsupporting

confidence: 72%

“…Adenoid cystic carcinoma (AdCC) is a distinct type of carcinoma arising in the major and minor salivary glands and, less commonly, in the seromucinous glands of the upper respiratory tract . Cytological examination has been recognized as a useful tool for diagnosis of AdCC of the salivary glands and the seromucinous glands …”

Section: Introductionmentioning

confidence: 99%

Cytological features of dedifferentiated adenoid cystic carcinoma of the trachea

Kagotani

Ishida

Yoshida

et al. 2013

Diagnostic Cytopathology

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“…The latter is discussed in an article describing an example of MASC arising in an accessory parotid gland, while an additional paper focuses attention on another rare variant of salivary gland tumors: a hyalinized clear cell carcinoma of the parotid gland, with an aggressive behavior . As to emphasize the unusual location of salivary gland‐type tumors, a case of adenoid cystic carcinoma of the auditory canal is also described, with architectural and cyto‐histological features indistinguishable from conventional adenoid cystic carcinoma of the major and minor salivary glands …”

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confidence: 99%

There is more than meet the eyes in head and neck cytopathology

Baloch¹,

Bubendorf²,

Bedrossian³

2013

Diagnostic Cytopathology

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This issue of Diagnostic Cytopathology is dedicated to cytopathology of the head and neck region, which begs a question and several definitions. What do clinicians, pathologists and patients mean when they say: "head and neck". More pertinently, do cytopathologists think mainly of "head and neck lumps" when thinking of cytopathology of the head and neck? The truth is, somewhat arbitrarily, we have gradually come to think mainly of lumps, located in the thyroid and the parathyroid glands, the major salivary glands, the cervical lymph nodes, and the soft tissue tumors of the region above the clavicle as the usual territory of head and neck cytopathology. Our selection of papers is intended as food for thought in 1) expanding the way we view cytopathology of the head and neck, not only as diagnostic and prognostic, but also as capable of impacting treatment and enabling the recognition of novel targets of molecular therapies 2) extending it beyond just lumps and bumps, by refocusing attention on the use of exfoliative cytology for the study of mucosal abnormalities 3) re-emphasizing that the eyes, the pituitary and the pineal gland as well as the leptomeninges can be evaluated cytologically and are part of the head and neck; and 4) recognizing that a wider range of lesions, to include tumors originating in the skin, subcutaneous, nerve, lymphoid, bone and soft tissues as well as metastatic lesions can occur anywhere in head and neck region. Such an amplified view extends also to remembering that any structure of the head and neck can be the site of lesions of varied histogenesis, be it metabolic, inflammatory, infectious, allergic, immunologic or neoplastic in nature.As the articles in this issue demonstrate, one of the most complex regions of the human body, the head and neck includes a myriad of interrelated but uniquely different organs, each with its own scientific field of study and clinical specialty, or group of specialties. Otolaryngology, commonly called ENT for "ear, nose and throat" is the oldest medical specialty in the US, but is far from being clearly defined. Practiced by surgical as well as nonsurgical specialists, ENT uses countless procedures to maximize diagnosis and treatment of head and neck lesions. In fact, one of the earliest papers on the cytology of the ear, nose and throat was published in the Journal of Laryngology & Otology, at a time when exfoliative cytology was the norm. 1 In case you are wondering, yes, there is a journal of Rhinology, founded in 1963, which represents at least four Rhinology societies: respectively, the International, the European, the American and the Japanese Society of Rhinology.There are at least three dozen additional scientific journals dedicated to clinical aspects of conditions affecting the head and neck. These publications cover both neoplastic and non-neoplastic conditions, described by clinicians, surgeons, pathologists and other specialists, with emphasis on histopathology and a smattering of cytology oriented papers. The vast majority of the cytopathol...

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Surgical outcomes of 43 cases with adenoid cystic carcinoma of the external auditory canal

Chi

Dai

et al. 2013

American Journal of Otolaryngology

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Adenoid cystic carcinoma of the external auditory canal successfully diagnosed by fine‐needle aspiration

Cited by 5 publications

References 10 publications

Cytological features of dedifferentiated adenoid cystic carcinoma of the trachea

Cytological features of dedifferentiated adenoid cystic carcinoma of the trachea

There is more than meet the eyes in head and neck cytopathology

Surgical outcomes of 43 cases with adenoid cystic carcinoma of the external auditory canal

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