Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence

Chen, Allen M.; Bucci, M. Kara; Weinberg, Vivian; García, Joaquín J.; Quivey, Jeanne M.; Schechter, Naomi R.; Phillips, Theodore L.; Fu, Karen K.; Eisele, David W.

doi:10.1016/j.ijrobp.2006.04.014

Cited by 261 publications

(308 citation statements)

References 27 publications

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“…In agreement with previous studies (1,7,8,10), we found that ACC in our patients had a high recurrence rate, similar to that observed in the study of Chen et al (18). The recurrence rate was up to 40.5%, and mostly occurred within 5 years of initial treatment.…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

“…This phenomenon has been demonstrated by positron emission tomography (PET) using 18 F-2-fluoro-2-deoxy-D-glucose ( 18 F-FDG) (9). Many mechanisms of 18 F-FDG uptake have been proposed for accelerated glucose use in growing tumors and in transformed and malignant cells. These include passive diffusion, Na + -dependent glucose transport and facilitative glucose transporters (GLUTs) (10), with GLUTs considered to be the most significant mechanism for enhancing glucose influx into cells.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

et al. 2012

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Abstract. The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

et al. 2012

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“…Although postoperative radiation seems to improve local control rates, the impact on ACC‐specific survival is not clear 43, 50, 51. Evaluation of survival is confounded by the requirement for long‐term follow‐up as one half of recurrences manifest after 5 years.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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BackgroundAdenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed.MethodsA search of articles in PubMed and of abstracts from national meetings was performed regarding ACC.ResultsRecent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare.ConclusionACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. 38: 620–627, 2016

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“…Although good local control is usually achieved by resection of the primary tumor, often accompanied by post-operative radiation therapy, late recurrence is common both regionally and at distant sites. Local recurrence is attributed in part due to the proclivity of ACC for perineural invasion [21][22][23]. The neurotropism also contributes to the infiltrative nature of this neoplasm, with deep penetration of vital structures of the craniofacial region along major nerve trunks [24].…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma: Clinical and Molecular Features

Moskaluk

2013

Head and Neck Pathol

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The clinical features and common molecular alterations of adenoid cystic carcinoma (ACC) are reviewed in this paper. ACC is an uncommon neoplasm that most frequently arises in salivary glands and related tissue in the head and neck region. ACC has distinct histologic features, with cribriform and tubular growth patterns of basaloid cells displaying a predominantly myoepithelial cellular phenotype. This neoplasm also has uncommon clinical features of rare regional lymph node metastasis and a prolonged but relentlessly progressive clinical course. Clinical outcome in ACC is correlated to histologic grade, which is correlated to the degree of aneuploidy and genetic alterations present in the tumor genomes. Recent studies have identified that the majority of ACC contain alterations of the MYB gene, usually resulting in a fusion gene product with the NFIB gene by a t(6;9) translocation event. The molecular consequences of this alteration are incompletely understood, as are secondary molecular alterations that contribute to the neoplastic phenotype of ACC.

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Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence

Cited by 261 publications

References 27 publications

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Adenoid Cystic Carcinoma: Clinical and Molecular Features

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