Adenoid Cystic Carcinoma of the Breast

Leeming, Rosemary; Jenkins, Mark A.; Mendelsohn, Geoffrey

doi:10.1001/archsurg.1992.01420020127019

Cited by 65 publications

(53 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…adenoid cystic carci noma presents as a mass that is occasionally tender to palpation. The tumor is rarely fixed to the overlying skin, nipple, or pectoral muscles [6]. All cases presenting signs of microscopic in vasionshowedeitherill-definedor partiallyill definedmarginson mammograms (Fig.…”

Section: Billroth Coinedthe Term â€Oe¿ Cylindromaâ€• In Hismentioning

confidence: 99%

Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Santamaría¹,

Velasco²,

Zanón³

et al. 1998

American Journal of Roentgenology

View full text Add to dashboard Cite

A denoidcysticcarcinomais a rarevariant of adenocarcinoma that usually occursinthemajorand minor salivary glands. Nevertheless, tumors with this patternhavebeenobservedin other organs including the breast, tracheobronchial tree, uterine cervix, larynx, and Bartholin's gland[ 1â€"5]. The cell of origin is obscure, but evidence suggests that it may be derived from the ductal epithelium and myoepithe hum [6]. Pathologically, the presenceof both cell types is necessary for the diagnosis of adenoidcysticcarcinomaof the breast.Adenoid cystic carcinoma of the breast constitutes lessthan 1% of all mammarycar cinomas. This unusual neoplasm of the breast has certain histopathologicand bio logic characteristics that distinguish it from more common histologic types. For example, the incidence of axillary lymph node in volvement is lower and distant metastases are uncommon, although they can occur without prior lymph nodeinvolvement.This lack of prognostic significance for negative axillary lymph nodes suggests that axillary dissectioncan be eliminatedfrom the surgi cal treatment of low-grade adenoid cystic carcinoma and that wide excision alone couldbe curativein thosecases[6]. The mammographic features of these le sions have scarcely been reported in the liter ature to our knowledge. We describe the clinical and mammographicfindingsand the histopathologic features of seven cases of proven adenoid cystic carcinoma. Materials and MethodsA retrospective review of all cases of pathologi cally proven adenoid cystic carcinoma of the breast between 1988and 1996 was undertakenat our de partment. During this 8-year period. a total of 1015 invasivebreast tumors were diagnosed:sevencases of adenoid cysticcarcinoma of thebreast werein cluded in the study. Clinical histories, mammo grams, and cytologic and histologic studies of these patients were reviewed. Women were from 40 to 79 years old (mean age. 60 years old).All patients underwent conventional X-ray mam mography. Standard craniocaudal and mediolateral oblique views of each breast were obtained.

show abstract

Section: Billroth Coinedthe Term â€Oe¿ Cylindromaâ€• In Hismentioning

confidence: 99%

Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Santamaría¹,

Velasco²,

Zanón³

et al. 1998

American Journal of Roentgenology

View full text Add to dashboard Cite

show abstract

“…Pathological criteria of ACC involves biphasic cellular pattern consists of basaloid myoepithelial cells together with ductal epithelial cells (7). In the presented case, a triple negative phenotype was detected.…”

Section: Case Reportmentioning

confidence: 52%

Adenoid Cystic Carcinoma of the Breast: A Rare Histopathology- Good Prognosis

Eşbah¹,

Ekinci²,

Benzer³

et al. 2013

Acta Oncol Tur.

View full text Add to dashboard Cite

ÖZET Giriş: Adenoid kistik karsinom (AKK), memenin nadir görülen neoplazmlarındandır. Tüm meme karsinomlarının %0.1'ini oluşturmaktadır. AKK'lar memede izlenen diğer histolojik alt tiplerine göre çok iyi prognoza sahiptirler. Uzak metastaz ve lenf nodu tutulumu çok nadirdir. Sıklıkla östrojen reseptörü (ER), progesteron reptörü (PR) ve c-erbB2 durumu negatif olarak tespit edilmektedir. Olgu: Kırksekiz yaşında premenapozal kadın hasta sol memede ele gelen kitle nedeniyle doktora başvurmuş. Hastaya memedeki lezyon için tru-cut biyopsi uygulandı. Biyopsi sonucunun AKK olarak gelmesi üzerine hastaya modifiye radikal mastektomi operasyonu uygulandı. Operasyon materyalinin patolojik incelemesi orta derecede diferansiye AKK ile uyumlu olarak tespit edildi. Tümör boyutu 4.8 cm ve aksiller diseksiyon sonucu 48 lenf nodu negatif olarak tespit edildi. Tümörün immünohistokimyasal özellikleri triple negatif (ER, PR ve cerbB2) olarak değerlendirildi. Sonuç: AKK'ler çoğunlukla ER(-), PR(-) ve c-erbB2 (-) durumu ile ender görülen meme karsinomlarıdır. AKK'ler nadir görülen meme karsinomları olduğundan ve yeterli klinik çalışma bulunmadığından tedavi opsiyonları sınırlıdır. Anahtar Kelimeler: Meme neoplazm; adenoid kistik karsinom; iyi prognoz ABSTRACT Background: Adenoid cystic carcinoma (ACC), one of the rarest neoplasia of the breast, constitutes 0.1% of all breast carcinomas. The prognosis of ACC is very good compared to other histological subtypes of breast carcinoma. Lymph node involvement and distant metastasis are very infrequent. Estrogen receptor (ER), progesterone receptor (PR) and c-erbB2 (also known as HER-2/neu) are typically negative. Case Report: A fourty eight year-old premenauposal women was admitted to hospital with a mass on the upper outer quadrant of her left breast. Since the result of through-cut biopsy of this suspicious lesion was consistent with adenoid cystic carcinoma, modified radical mastectomy with axillary lymph node excision was applied. Pathological examination revealed a moderately differantiated adenoid cystic carcinoma of the breast. The size of invasive tumor component was 4.8 cm in its greatest dimension. Immunohistochemical analysis was consistent with triple negative phenotype (ER,PR and c-erbB2 negative). Conclusion: ACC is a rare type of human breast carcinoma with ER, PR and c-erbB2 negative phenotype. They usually show an excellent prognosis however there is no well defined treatment options for ACC since the rarity of clinical studies in such kind of unusual histological subtypes of breast carcinomas.

show abstract

“…AAC of the breast also showed lower proliferative activity with PR and ER usually negative. Leeming et al (5) reviewed 140 cases and found only one case positive in ER. However, in a different group, which consisted of 14 cases, there were 4 positive in ER and in a separate group of 13, there were 3 positive in PR (6).…”

Section: Discussionmentioning

confidence: 99%

“…Sumpio et al (9) reported 6 cases of local recurrence following simple lumpectomy, out of a total of 8 cases. Leeming et al (5) noted that 9 out of 24 patients suffered from local recurrence following simple lumpectomy, a recurrence rate of 37%. Youk et al (15) described a case of local recurrence following successful treatment by lumpectomy and systemic chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…With respect to histologic pathology, its cellular composition comprises ductal epithelioid cells and basaloid myoepithelial cells (4), although there is no commonly accepted origination. Leeming et al showed evidence that ACC originates from the ductal epithelium and myoepithelium (5). Due to its favorable prognosis, accurate clinical diagnosis and differential diagnosis are of significant importance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adenoid cystic carcinoma of the breast: Review of the literature and report of two cases

Wang

Yao

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

Abstract. In this study, we report two cases of adenoid cystic carcinoma (ACC) of the breast. Two women presented to our hospital with a tender lump in the breast. Mammography and ultrasonography both revealed an ill-defined mass in the breast. We performed modified radical mastectomies on the patients, and pathological assessment following surgery showed ACC of the breast. Both patients received chemotherapy following surgery, have been followed up to date and remain in good health. In this study, we report these two rare cases and review the existing literature regarding ACC of the breast.

show abstract

Adenoid Cystic Carcinoma of the Breast

Cited by 65 publications

References 18 publications

Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Adenoid Cystic Carcinoma of the Breast: A Rare Histopathology- Good Prognosis

Adenoid cystic carcinoma of the breast: Review of the literature and report of two cases

Contact Info

Product

Resources

About